Primary Site >> Pancreatic Cancer
Gene >> STAT1
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Ref: Interferon-mediated activation of the STAT signaling pathway in a human carcinoid tumor. PMID: 9831114 |
Ref: The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. PMID: 15123776 |
Ref: Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway. PMID: 15637593 |
Ref: Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. PMID: 17116388 |
Ref: Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma--epigenetic downregulation of caspases. PMID: 18649362 |
Ref: The fungal secondary metabolite trichodimerol inhibits TGF-beta dependent cellular effects and tube formation of MDA-MB-231 cells. PMID: 19009233 |
Ref: Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells. PMID: 19757157 |
Ref: Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach. PMID: 21310022 Ref: Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines. PMID: 21321110 Ref: Novel TGF-beta antagonist inhibits tumor growth and angiogenesis by inducing IL-2 receptor-driven STAT1 activation. PMID: 21551368 |
Ref: Nicotine, IFN-gamma and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. PMID: 22537161 Ref: Mathematical modelling unravels regulatory mechanisms of interferon-gamma-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells. PMID: 22757586 Ref: Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer. PMID: 23170143 Ref: Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. PMID: 23185240 Ref: Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells. PMID: 23284277 |
Ref: Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma. PMID: 23204224 Ref: Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-gamma and lipopolysaccharide in human pancreatic cancer cell lines. PMID: 23296709 Ref: Expression profiles analysis of pancreatic cancer. PMID: 23426533 Ref: Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. PMID: 23514705 Ref: A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer. PMID: 23993964 Ref: STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2. PMID: 25364701 |
Ref: Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis. PMID: 24658320 |
Ref: Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular "pseudoinflammation" contributing to an aggressive phenotype. PMID: 25650658 Ref: Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer. PMID: 25686822 Ref: Pancreatic adenocarcinoma upregulated factor (PAUF) confers resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNA receptor-mediated signaling. PMID: 25727013 Ref: Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1. PMID: 26331681 |
Ref: Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. PMID: 27213290 Ref: Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. PMID: 27535971 |
Ref: IL-21 Enhances Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells. PMID: 27435400 Ref: The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines. PMID: 28112370 Ref: Tumour-associated macrophages activate migration and STAT3 in pancreatic ductal adenocarcinoma cells in co-cultures. PMID: 28476581 Ref: Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNgamma signaling. PMID: 28680757 Ref: Nitric oxide mediated inhibition of antigen presentation from DCs to CD4(+) T cells in cancer and measurement of STAT1 nitration. PMID: 29133913 |
Ref: Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice. PMID: 28989066 Ref: L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway. PMID: 29606890 |