Primary Site >> Colorectal Cancer
Gene >> STAT1
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Ref: IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. PMID: 8609418 |
Ref: Transcriptional silencing of perlecan gene expression by interferon-gamma. PMID: 9468523 |
Ref: Interleukin-4 mediates cell growth inhibition through activation of Stat1. PMID: 10744706 Ref: Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate. PMID: 10866311 |
Ref: p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. PMID: 11139340 |
Ref: STAT1 is required for IFN-gamma-mediated gut-enriched Kruppel-like factor expression. PMID: 12441126 |
Ref: Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression. PMID: 12972432 |
Ref: Requirement of histone deacetylase activity for signaling by STAT1. PMID: 15123634 Ref: NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs. PMID: 15240129 Ref: IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. PMID: 15284182 |
Ref: 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal tra PMID: 16077033 Ref: Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer. PMID: 16204068 |
Ref: Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of c-myc suppression by interferon-gamma in situ. PMID: 16367922 Ref: IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. PMID: 16717119 Ref: Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation. PMID: 16928387 |
Ref: STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma; a common pathway of IFNgamma-mediated gene repression but not gene activation. PMID: 17016440 Ref: Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate. PMID: 17251186 Ref: The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. PMID: 17438334 Ref: Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. PMID: 17449633 Ref: Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR. PMID: 17804871 Ref: Histone deacetylase inhibitors induce cell death selectively in cells that harbor activated kRasV12: The role of signal transducers and activators of transcription 1 and p21. PMID: 17875686 |
Ref: STAT1 expression is not required for polyp formation in Min mice. PMID: 17683066 Ref: The role of signal transducers and activators of transcription in colon cancer. PMID: 17981761 Ref: Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1. PMID: 18035482 Ref: HPP1-mediated tumor suppression requires activation of STAT1 pathways. PMID: 18059030 Ref: A novel tumor-promoting function residing in the 5' non-coding region of vascular endothelial growth factor mRNA. PMID: 18494554 |
Ref: Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level. PMID: 19046253 Ref: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide--interference with interferon-gamma-STAT1-mediated killing. PMID: 19476491 Ref: A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. PMID: 19616522 Ref: Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. PMID: 19701245 |
Ref: MicroRNA-145 targets YES and STAT1 in colon cancer cells. PMID: 20098684 Ref: STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells. PMID: 20407011 Ref: Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer. PMID: 20581241 Ref: Anticancer properties of the IL-12 family--focus on colorectal cancer. PMID: 20712574 Ref: A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. PMID: 20712901 Ref: IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. PMID: 20855874 |
Ref: Methylation-specific ligation detection reaction (msLDR): a new approach for multiplex evaluation of methylation patterns. PMID: 21879293 Ref: ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression. PMID: 21937683 |
Ref: A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. PMID: 22423663 Ref: Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. PMID: 22517765 Ref: Tumor-induced myeloid-derived suppressor cell function is independent of IFN-gamma and IL-4Ralpha. PMID: 22673957 Ref: Interleukin-26, a highly cationic T-cell cytokine targeting epithelial cells. PMID: 23106140 Ref: (-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells. PMID: 23741252 |
Ref: JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. PMID: 22121102 Ref: IFNalpha converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. PMID: 23153456 Ref: Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. PMID: 23756862 Ref: Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation. PMID: 23917355 Ref: A Predictive Genetic Signature for Response to Fluoropyrimidine-Based Neoadjuvant Chemoradiation in Clinical Stage II and III Rectal Cancer. PMID: 24324931 |
Ref: The Role of STAT1 for Crosstalk between Fibroblasts and Colon Cancer Cells. PMID: 24818101 Ref: Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. PMID: 24837432 Ref: Resveratrol modulates cytokine-induced Jak/STAT activation more efficiently than 5-aminosalicylic acid: an in vitro approach. PMID: 25271420 |
Ref: Expressional STAT3/STAT5 Ratio is an Independent Prognostic Marker in Colon Carcinoma. PMID: 25773877 Ref: The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways. PMID: 26061044 Ref: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. PMID: 26388988 Ref: Tumour-promoting role of SOCS1 in colorectal cancer cells. PMID: 26391193 |
Ref: FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter. PMID: 26676844 Ref: Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer. PMID: 26719345 Ref: FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin. PMID: 26759270 Ref: Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore. PMID: 26852363 Ref: A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells. PMID: 26883202 Ref: Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. PMID: 26985305 Ref: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. PMID: 27191495 Ref: 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. PMID: 27326329 Ref: Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. PMID: 27490956 Ref: Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. PMID: 27682874 Ref: Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis. PMID: 27757304 Ref: STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A. PMID: 27913706 |
Ref: The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network. PMID: 27893714 Ref: T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. PMID: 27935860 Ref: Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3. PMID: 28154246 Ref: Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells. PMID: 28179289 Ref: Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, p53, and Bax and Downregulation of c-Myc and Bcl-2. PMID: 28282916 Ref: The miR-124-p63 feedback loop modulates colorectal cancer growth. PMID: 28418858 Ref: Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer. PMID: 28507795 Ref: Proinflammatory Cytokines IL-6 and TNF-alpha Increased Telomerase Activity through NF-kappaB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells. PMID: 28676732 Ref: Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista. PMID: 28711499 Ref: Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway. PMID: 28903386 |
Ref: HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer. PMID: 27345726 Ref: MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. PMID: 29031499 Ref: KRAS Mutation and Consensus Molecular Subtypes 2 and 3 Are Independently Associated with Reduced Immune Infiltration and Reactivity in Colorectal Cancer. PMID: 29061646 Ref: The function of BTG3 in colorectal cancer cells and its possible signaling pathway. PMID: 29270670 Ref: STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer. PMID: 29419930 Ref: STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ. PMID: 29729381 Ref: L-carnosine induces apoptosis/cell cycle arrest via suppression of NF-kappaB/STAT1 pathway in HCT116 colorectal cancer cells. PMID: 29869056 Ref: Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development. PMID: 30235866 Ref: Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. PMID: 30333916 |