Primary Site >> Pancreatic Cancer
Gene >> SRC
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Ref: Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma. PMID: 9480838 Ref: Src stimulates insulin-like growth factor I (IGF-I)-dependent cell proliferation by increasing IGF-I receptor number in human pancreatic carcinoma cells. PMID: 9721859 |
Ref: AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. PMID: 11212254 Ref: Oncogenes, growth factors, receptor expression and proliferation markers in digestive neuroendocrine tumours. A critical reappraisal. PMID: 11762339 |
Ref: Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line. PMID: 12593846 Ref: Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1. PMID: 12750255 Ref: Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin. PMID: 12832415 Ref: Src family kinases in tumor progression and metastasis. PMID: 12884910 Ref: Inhibition of tyrosine kinase Src suppresses pancreatic cancer invasiveness. PMID: 12947321 Ref: Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. PMID: 14627343 |
Ref: Identification and characterization of human DIAPH3 gene in silico. PMID: 14767582 Ref: Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant. PMID: 15292208 Ref: Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. PMID: 15585638 |
Ref: Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. PMID: 16103072 Ref: c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK. PMID: 16163059 Ref: AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. PMID: 16373705 |
Ref: Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. PMID: 16332692 Ref: Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. PMID: 16507911 Ref: Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. PMID: 16546976 Ref: Tyrosine kinase inhibitors and gemcitabine: new treatment options in pancreatic cancer? PMID: 16621676 Ref: Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice. PMID: 16773192 Ref: Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells. PMID: 16871430 Ref: Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas. PMID: 16874861 Ref: N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. PMID: 17064066 Ref: Characterization of the CXCR4 signaling in pancreatic cancer cells. PMID: 18175225 |
Ref: Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors). PMID: 16540233 Ref: Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1. PMID: 17471232 Ref: Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer. PMID: 17486419 Ref: Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1. PMID: 17974973 Ref: SRC family nonreceptor tyrosine kinases as molecular targets for cancer therapy. PMID: 18045060 |
Ref: Inhibition of Src reduces gemcitabine-induced cytotoxicity in human pancreatic cancer cell lines. PMID: 18078709 Ref: Src kinase and pancreatic cancer. PMID: 18084959 Ref: ANTI-ADHESION evolves to a promising therapeutic concept in oncology. PMID: 18393855 Ref: Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling. PMID: 18794807 Ref: Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer. PMID: 18797457 Ref: New treatment options for advanced pancreatic cancer. PMID: 19072345 Ref: Small molecule tyrosine kinase inhibitors in pancreatic cancer. PMID: 19707451 |
Ref: Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models. PMID: 18924149 Ref: EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2. PMID: 19116140 Ref: Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. PMID: 19208836 Ref: Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo. PMID: 19469020 Ref: Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer. PMID: 19509160 Ref: Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts. PMID: 19509264 Ref: An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. PMID: 19734908 |
Ref: A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. PMID: 20067773 Ref: Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src. PMID: 20100905 Ref: Any second-line therapy for advanced pancreatic cancer? Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010. PMID: 20208325 Ref: Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PMID: 20209107 Ref: Src tyrosine kinase inhibition suppresses lymphangiogenesis in vitro and in vivo. PMID: 20370688 Ref: Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity. PMID: 20457609 Ref: Higher expression of the heterogeneous nuclear ribonucleoprotein k in melanoma. PMID: 20499280 Ref: Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. PMID: 20682659 Ref: Loss of tyrosine phosphatase-dependent inhibition promotes activation of tyrosine kinase c-Src in detached pancreatic cells. PMID: 20945416 |
Ref: Focal adhesion kinase signaling and function in pancreatic cancer. PMID: 21196348 Ref: Oncogenic Ras/Src cooperativity in pancreatic neoplasia. PMID: 21242978 Ref: Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth. PMID: 21266529 Ref: Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer. PMID: 21461171 Ref: A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells. PMID: 21573184 Ref: Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-extracellular signal-regulated kinase (ERK). PMID: 21613217 Ref: Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks. PMID: 21859838 Ref: Molecular pathogenesis of pancreatic cancer and clinical perspectives. PMID: 22116519 |
Ref: A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer. PMID: 21170669 Ref: Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. PMID: 21841817 Ref: EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. PMID: 21963850 Ref: The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells. PMID: 22038627 Ref: Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. PMID: 22072614 Ref: Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors alpha3, alpha5, and alpha7. PMID: 22188668 Ref: A study of the suppressive effect on human pancreatic adenocarcinoma cell proliferation and angiogenesis by stable plasmid-based siRNA silencing of c-Src gene expression. PMID: 22200682 Ref: DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA. PMID: 22223849 Ref: Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype. PMID: 22471946 Ref: The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells. PMID: 22479394 Ref: Nicotine, IFN-gamma and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. PMID: 22537161 Ref: KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. PMID: 22589274 Ref: Src-mediated regulation of E-cadherin and EMT in pancreatic cancer. PMID: 22652764 Ref: CD24 controls Src/STAT3 activity in human tumors. PMID: 22760497 Ref: Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer. PMID: 22761868 Ref: Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters. PMID: 22791813 Ref: Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro and in xenograft models of stress-free and stress-exposed mice. PMID: 22916251 Ref: Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE. PMID: 23142633 Ref: Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. PMID: 23308043 Ref: Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer. PMID: 23342270 |
Ref: Chronic nicotine inhibits the therapeutic effects of gemcitabine on pancreatic cancer in vitro and in mouse xenografts. PMID: 23146955 Ref: Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. PMID: 23206899 Ref: Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. PMID: 23222813 Ref: Targeting the yin and the yang: combined inhibition of the tyrosine kinase c-Src and the tyrosine phosphatase SHP-2 disrupts pancreatic cancer signaling and biology in vitro and tumor formation in vivo. PMID: 23271399 Ref: A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies. PMID: 23361621 Ref: Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. PMID: 23650499 Ref: Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer. PMID: 23749641 Ref: Protease-activated receptor-2 induces migration of pancreatic cancer cells in an extracellular ATP-dependent manner. PMID: 23899344 Ref: Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. PMID: 23920124 Ref: Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex. PMID: 24339867 |
Ref: Vav1 as a central regulator of invadopodia assembly. PMID: 24332539 Ref: Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-beta to promote proliferation. PMID: 24334458 Ref: Src inhibition is still a relevant target in pancreatic cancer. PMID: 24457377 Ref: CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis. PMID: 24468059 Ref: Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells. PMID: 24676703 Ref: The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion. PMID: 24763074 Ref: Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints. PMID: 24955955 Ref: Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PMID: 25170871 Ref: Elongation factor-2 kinase regulates TG2/beta1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion. PMID: 25215932 Ref: Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PMID: 25268648 Ref: Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging. PMID: 25482620 |
Ref: Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells. PMID: 25047070 Ref: A preclinical evaluation of SKLB261, a multikinase inhibitor of EGFR/Src/VEGFR2, as a therapeutic agent against pancreatic cancer. PMID: 25519702 Ref: Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion. PMID: 25561562 Ref: Molecular pathogenesis and targeted therapy of sporadic pancreatic neuroendocrine tumors. PMID: 25619712 Ref: S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase. PMID: 25677816 Ref: N of 1 case reports of exceptional responders accrued from pancreatic cancer patients enrolled in first-in-man studies from 2002 through 2012. PMID: 25897431 Ref: Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer. PMID: 26065715 Ref: Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer. PMID: 26320171 Ref: Novel agents for advanced pancreatic cancer. PMID: 26369833 Ref: Role of sphingosine 1-phosphate in human pancreatic cancer cells proliferation and migration. PMID: 26884951 |
Ref: A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer. PMID: 26695438 Ref: Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancer. PMID: 26803204 Ref: Src/STAT3 signaling pathways are involved in KAI1-induced downregulation of VEGF-C expression in pancreatic cancer. PMID: 27082851 Ref: Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro. PMID: 27175782 Ref: Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells. PMID: 27503856 Ref: Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells. PMID: 27760157 |
Ref: Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer. PMID: 27821486 Ref: Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity. PMID: 28255353 Ref: Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers. PMID: 28390937 Ref: A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution. PMID: 28746882 |
Ref: Dual Src and EGFR inhibition in combination with gemcitabine in advanced pancreatic cancer: phase I results : A phase I clinical trial. PMID: 28990119 Ref: Downregulated miR-23b-3p expression acts as a predictor of hepatocellular carcinoma progression: A study based on public data and RT-qPCR verification. PMID: 29484429 Ref: P21-activated kinase 4 in pancreatic acinar cells is activated by numerous gastrointestinal hormones/neurotransmitters and growth factors by novel signaling, and its activation stimulates secretory/growth cascades. PMID: 29672153 Ref: Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways. PMID: 29749405 Ref: Synergistic Anti-Cancer Effects of AKT and SRC Inhibition in Human Pancreatic Cancer Cells. PMID: 29978609 Ref: Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals. PMID: 29980405 Ref: The therapeutic targeting of the FGFR1/Src/NF-kappaB signaling axis inhibits pancreatic ductal adenocarcinoma stemness and oncogenicity. PMID: 29987671 Ref: Allergenremoved Rhus verniciflua Stokes suppresses invasion and migration of pancreatic cancer cells through downregulation of the JAK/STAT and Src/FAK signaling pathways. PMID: 30226611 Ref: Gemcitabine exhibits a suppressive effect on pancreatic cancer cell growth by regulating processing of PVT1 to miR1207. PMID: 30341811 |