Primary Site >> Colorectal Cancer
Gene >> SRC
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Ref: Cultured cells transformed by Rous sarcoma virus: a genetically defined model and its phenotype. PMID: 6190185 |
Ref: Human tumor xenografts transplanted under the renal capsule of conventional mice. Growth rates and host immune response. PMID: 6500747 |
Ref: Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues. PMID: 3093483 |
Ref: Activation of pp60c-src protein kinase activity in human colon carcinoma. PMID: 2436227 Ref: Analysis of pp60c-src tyrosine kinase activity and phosphotyrosyl phosphatase activity in human colon carcinoma and normal human colon mucosal cells. PMID: 2448318 Ref: Analysis of pp60c-src in human colon carcinoma and normal human colon mucosal cells. PMID: 2453014 |
Ref: Phenotypic and genetic alterations in pre-cancerous cells in the colon. PMID: 3052255 Ref: Biological characterization and oncogene expression in human colorectal carcinoma cell lines. PMID: 3338874 |
Ref: Alterations in the expression of pp60c-src and p56lck associated with butyrate-induced differentiation of human colon carcinoma cells. PMID: 2476706 Ref: pp60c-src activation in human colon carcinoma. PMID: 2498394 |
Ref: Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis. PMID: 2105487 Ref: src expression in small-cell lung carcinoma and other neuroendocrine malignancies. PMID: 2174663 Ref: Human cellular src gene product: identification of the myristoylated pp60c-src and blockage of its myristoyl acylation with N-fatty acyl compounds resulted in the suppression of colony formation. PMID: 2268350 |
Ref: Effect of herbimycin A on growth and pp60c-src activity in human colon tumor cell lines. PMID: 1719464 Ref: Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. PMID: 2000223 |
Ref: Expression of the gene coding for the light chain of calpactin I (annexin II) in cell lines DiFi, HT-29, and WI-38. PMID: 1280033 Ref: Growth inhibition of human colorectal carcinoma cell lines by tumor necrosis factor-alpha correlates with reduced activity of pp60c-src. PMID: 1381217 Ref: Molecular genetics of colorectal carcinoma. PMID: 1511369 Ref: Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma. PMID: 1540900 |
Ref: Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. PMID: 7678609 Ref: Signal transduction through extracellular signal-regulated kinase-like pp57 blocked in differentiated colon carcinoma cells having low levels of c-src kinase. PMID: 7681838 Ref: Site-specific differences in pp60c-src activity in human colorectal metastases. PMID: 7687314 Ref: c-Yes tyrosine kinase activity in human colon carcinoma. PMID: 7690925 Ref: Signal transduction in c-met mediated motogenesis. PMID: 8380734 |
Ref: Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis. PMID: 7509341 Ref: Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. PMID: 7527393 Ref: Activity of pp60c-src in 60 different cell lines derived from human tumors. PMID: 7537173 Ref: Immunohistochemically demonstrable pp60(c-SRC) in human breast-cancer. PMID: 21607411 |
Ref: Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association. PMID: 7478513 Ref: Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas. PMID: 7478590 Ref: Cell spreading in Colo 201 by staurosporin is alpha 3 beta 1 integrin-mediated with tyrosine phosphorylation of Src and tensin. PMID: 7530722 Ref: Expression of C-terminal src kinase in human colorectal cancer cell lines. PMID: 7533218 Ref: Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells. PMID: 7739521 Ref: Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha. PMID: 7797556 Ref: The genetic basis of colorectal cancer--clinical implications. PMID: 7851569 Ref: Colon carcinogenesis in inflammatory bowel disease. PMID: 23282306 |
Ref: Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease. PMID: 8674385 Ref: Syndecan-1 alterations during the tumorigenic progression of human colonic Caco-2 cells induced by human Ha-ras or polyoma middle T oncogenes. PMID: 8695359 Ref: Estradiol activation of human colon carcinoma-derived Caco-2 cell growth. PMID: 8813150 Ref: The role of Src family kinases in the normal and neoplastic gastrointestinal tract. PMID: 9129132 Ref: Differential activation of pp60(c-src) and pp62(c-yes) in human colorectal carcinoma liver metastases. PMID: 9816313 Ref: Genetics of colorectal cancer (Review). PMID: 21541519 Ref: Effect of cytochrome P450 inducers on expression of oncogenes and a tumor suppressor gene in human colon cancer cells. PMID: 21541530 |
Ref: Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion. PMID: 9010033 Ref: Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src. PMID: 9056668 Ref: Down-regulation of NF-kappaB activity and NF-kappaB p65 subunit expression by ras and polyoma middle T oncogenes in human colonic Caco-2 cells. PMID: 9129150 Ref: Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. PMID: 9142389 Ref: Adhesion of HT-29 colon carcinoma cells to E-selectin results in increased tyrosine phosphorylation and decreased activity of c-src. PMID: 9178821 Ref: [Oncogenic activation of p21ras or pp60c-src in human colonic Caco-2 cells induces post-translation alterations of syndecan-1]. PMID: 9207867 Ref: Src-mediated activation of the human neurotensin/neuromedin N promoter. PMID: 9288121 Ref: Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase. PMID: 9288158 Ref: Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential. PMID: 9419417 Ref: Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. PMID: 9444956 Ref: Changes in c-src activity in a human colon cancer cell line during differentiation. PMID: 21590078 |
Ref: Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src. PMID: 9422768 Ref: Elevated c-Src protein expression is an early event in colonic neoplasia. PMID: 9520949 Ref: Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase. PMID: 9523739 Ref: De novo expression of the alpha5beta1-fibronectin receptor in HT29 colon-cancer cells reduces activity of C-SRC. Increase of C-SRC activity by attachment on fibronectin. PMID: 9533767 Ref: Analysis of signaling protein kinases in human colon or colorectal carcinomas. PMID: 9690379 Ref: The human c-Src proto-oncogene promoter contains multiple targets for triplex-forming oligonucleotides. PMID: 9826266 |
Ref: Activating SRC mutation in a subset of advanced human colon cancers. PMID: 9988270 Ref: Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1. PMID: 10373450 Ref: [Preparation and characterization of potential antineoplastic agents]. PMID: 10401154 Ref: Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients. PMID: 10485460 Ref: Ubiquitin-dependent degradation of active Src. PMID: 10508617 Ref: Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest. PMID: 10626805 |
Ref: No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese. PMID: 10704743 Ref: Mutation of the SRC gene in endometrial carcinoma. PMID: 10804287 Ref: Deregulation of the cytoplasmic tyrosine kinase cSrc in the absence of a truncating mutation at codon 531 in human bladder carcinoma. PMID: 10873622 Ref: Expression of N-myristoyltransferase inhibitor protein and its relationship to c-Src levels in human colon cancer cell lines. PMID: 10891381 Ref: Lack of activating c-SRC mutations at codon 531 in rectal cancer. PMID: 10958949 Ref: Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. PMID: 10974196 Ref: Overexpression of the csk gene suppresses tumor metastasis in vivo. PMID: 11054667 |
Ref: Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells. PMID: 11156951 Ref: Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients. PMID: 11161376 Ref: SRC transcriptional activation in a subset of human colon cancer cell lines. PMID: 11163360 Ref: Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase- and thromboxane A2 receptor-dependent signaling pathways. PMID: 11427483 Ref: Reduced C-terminal Src kinase activity is correlated inversely with pp60(c-src) activity in colorectal carcinoma. PMID: 11443610 Ref: Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells. PMID: 11487584 |
Ref: Tumor necrosis factor alpha stimulates invasion of Src-activated intestinal cells. PMID: 11832448 Ref: Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. PMID: 11875501 Ref: Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. PMID: 11900220 Ref: Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells. PMID: 11980666 Ref: Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. PMID: 12134161 Ref: The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. PMID: 12214274 Ref: Identification of Src transformation fingerprint in human colon cancer. PMID: 12370817 Ref: Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells. PMID: 12402152 Ref: Src protein kinase pp60c-src influences adhesion stabilization of HT-29 colon carcinoma cells to extracellular matrix components under dynamic conditions of laminar flow. PMID: 12416028 Ref: Src activation regulates anoikis in human colon tumor cell lines. PMID: 12420216 Ref: Pharmacogenomic strategies for developing customized chemotherapy in non-small cell lung cancer. PMID: 12437479 |
Ref: Identification of the SRC pyrimidine-binding protein (SPy) as hnRNP K: implications in the regulation of SRC1A transcription. PMID: 12595559 Ref: Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells. PMID: 12615962 Ref: Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. PMID: 12727858 Ref: Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tu PMID: 12748308 Ref: Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro. PMID: 12820418 Ref: Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. PMID: 12824187 Ref: Absence of adhesion triggers differential FAK and SAPKp38 signals in SW620 human colon cancer cells that may inhibit adhesiveness and lead to cell death. PMID: 12876384 Ref: Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. PMID: 12939401 |
Ref: Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. PMID: 14699482 Ref: Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. PMID: 14963042 Ref: Combination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness. PMID: 14977859 Ref: Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. PMID: 15010475 Ref: SRC gene expression in human cancer: the role of transcriptional activation. PMID: 15060621 Ref: Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. PMID: 15075377 Ref: Regulation of alternative SRC promoter usage in HepG2 hepatocellular carcinoma cells. PMID: 15276210 Ref: Rapid signalling pathway activation by androgens in epithelial and stromal cells. PMID: 15288763 Ref: Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant. PMID: 15292208 Ref: Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis. PMID: 15326164 Ref: Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29. PMID: 15336565 Ref: Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation. PMID: 15383630 Ref: Extracellular pressure stimulates colon cancer cell adhesion in vitro and to surgical wounds by Src (sarcoma protein) activation. PMID: 15546552 Ref: Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals. PMID: 15548175 Ref: Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. PMID: 15585638 |
Ref: Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. PMID: 15578590 Ref: Construction and characterization of multiple human colon cancer cell lines for inducibly regulated gene expression. PMID: 15669025 Ref: Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. PMID: 15735019 Ref: Iterative microarray and RNA interference-based interrogation of the SRC-induced invasive phenotype. PMID: 15753379 Ref: c-src activating mutation analysis in Chinese patients with colorectal cancer. PMID: 15818752 Ref: The role of the cytoskeleton in differentially regulating pressure-mediated effects on malignant colonocyte focal adhesion signaling and cell adhesion. PMID: 15917311 Ref: The SRC-induced mesenchymal state in late-stage colon cancer cells. PMID: 15942195 Ref: SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. PMID: 15958584 Ref: Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. PMID: 15961079 Ref: Butyrate regulates the expression of c-Src and focal adhesion kinase and inhibits cell invasion of human colon cancer cells. PMID: 16001424 Ref: The novel gene EG-1 stimulates cellular proliferation. PMID: 16024617 Ref: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. PMID: 16052481 |
Ref: Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. PMID: 16094635 Ref: Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. PMID: 16368433 Ref: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. PMID: 16371650 Ref: Methionine aminopeptidase 2 and cancer. PMID: 16386852 Ref: Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. PMID: 16432186 Ref: SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. PMID: 16489032 Ref: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. PMID: 16518840 Ref: Copper(II) and manganese(III) complexes of N'-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer. PMID: 16600465 Ref: Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells. PMID: 16609991 Ref: Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. PMID: 16619028 Ref: Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases. PMID: 16685275 Ref: Extracellular pressure stimulates tumor cell adhesion in vitro by paxillin activation. PMID: 16855384 Ref: [Timeline from discovery of 5-FU to development of an oral anticancer agent S-1 and its drug concept]. PMID: 16897967 Ref: Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2. PMID: 16920701 Ref: Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells. PMID: 16972245 Ref: Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo. PMID: 17132222 Ref: Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. PMID: 17148760 |
Ref: RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints. PMID: 17072338 Ref: PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. PMID: 17192274 Ref: FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. PMID: 17317726 Ref: Analysis of specific transcriptional regulators as early predictors of independent prognostic relevance in resected colorectal cancer. PMID: 17317820 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 Ref: Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase. PMID: 17496330 Ref: Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer. PMID: 17510314 Ref: Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells. PMID: 17552361 Ref: Analysis of pathway activity in primary tumors and NCI60 cell lines using gene expression profiling data. PMID: 17572360 Ref: An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells. PMID: 17651734 Ref: Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. PMID: 17671207 Ref: Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro. PMID: 17702597 Ref: Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. PMID: 17804738 Ref: [Molecular mechanism of gastrin increasing colon cancer cells' invasion]. PMID: 17825155 Ref: Alpha-actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction. PMID: 17898132 Ref: Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. PMID: 17898870 Ref: PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. PMID: 17974954 Ref: Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion. PMID: 17982677 Ref: Difluoro analogue of UCS15A triggers activation of exogenously expressed c-Src in HCT 116 human colorectal carcinoma cells. PMID: 18035832 Ref: SRC family nonreceptor tyrosine kinases as molecular targets for cancer therapy. PMID: 18045060 Ref: Targeting SRC and epidermal growth factor receptor in colorectal cancer: rationale and progress into the clinic. PMID: 19360146 |
Ref: Decreased CHK protein levels are associated with Src activation in colon cancer cells. PMID: 17934522 Ref: Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway. PMID: 18086662 Ref: Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. PMID: 18183590 Ref: The EGFR-STAT3 oncogenic pathway up-regulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition. PMID: 18245483 Ref: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. PMID: 18253061 Ref: Src kinase induces tumor formation in the c-SRC C57BL/6 mouse. PMID: 18351644 Ref: Regulation of Id1 expression by SRC: implications for targeting of the bone morphogenetic protein pathway in cancer. PMID: 18381431 Ref: ANTI-ADHESION evolves to a promising therapeutic concept in oncology. PMID: 18393855 Ref: Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. PMID: 18413814 Ref: The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1. PMID: 18463161 Ref: Is Src the key to understanding metastasis and developing new treatments for colon cancer? PMID: 18477987 Ref: Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration. PMID: 18482983 Ref: Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase. PMID: 18485715 Ref: Identification of a functional EGF-R/p60c-src/STAT3 pathway in colorectal carcinoma: analysis of its long-term prognostic value. PMID: 18503159 Ref: Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance. PMID: 18507034 Ref: Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation. PMID: 18556171 Ref: Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly. PMID: 18562041 Ref: Eps8 decreases chemosensitivity and affects survival of cervical cancer patients. PMID: 18566210 Ref: Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase. PMID: 18644992 Ref: Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice. PMID: 18704196 Ref: Effect of chemotherapeutic stress on induction of vascular endothelial growth factor family members and receptors in human colorectal cancer cells. PMID: 18790786 Ref: Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. PMID: 18922892 Ref: Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL. PMID: 18922903 Ref: Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor. PMID: 18940664 |
Ref: Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background. PMID: 18613032 Ref: Src activity alters alpha3 integrin expression in colon tumor cells. PMID: 18839319 Ref: Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. PMID: 19058300 Ref: Valproic acid enhances bosutinib cytotoxicity in colon cancer cells. PMID: 19123474 Ref: Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. PMID: 19138410 Ref: HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53. PMID: 19150257 Ref: Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. PMID: 19276381 Ref: Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells. PMID: 19382747 Ref: Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress. PMID: 19383922 Ref: [The design, synthesis and anticancer activity of 4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS]. PMID: 19449526 Ref: The signal pathways in azoxymethane-induced colon cancer and preventive implications. PMID: 19502780 Ref: Improving Response Rates to EGFR-Targeted Therapies for Head and Neck Squamous Cell Carcinoma: Candidate Predictive Biomarkers and Combination Treatment with Src Inhibitors. PMID: 19636423 Ref: Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays. PMID: 19638618 Ref: NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells. PMID: 19703310 Ref: A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. PMID: 19767770 Ref: Focal adhesion kinase functions as an akt downstream target in migration of colorectal cancer cells. PMID: 19956390 |
Ref: TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways. PMID: 20118200 Ref: Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK. PMID: 20133951 Ref: Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation. PMID: 20347121 Ref: Primary cell lines: false representation or model system? a comparison of four human colorectal tumors and their coordinately established cell lines. PMID: 20369042 Ref: The SRC family of protein tyrosine kinases: a new and promising target for colorectal cancer therapy. PMID: 20378502 Ref: Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. PMID: 20439492 Ref: p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation. PMID: 20453886 Ref: A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. PMID: 20462955 Ref: Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells. PMID: 20532039 Ref: Extracellular domain dependence of PTPalpha transforming activity. PMID: 20545765 Ref: Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer. PMID: 20682712 Ref: Strategies for overcoming inherent and acquired resistance to EGFR inhibitors by targeting downstream effectors in the RAS/PI3K pathway. PMID: 20718704 Ref: Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. PMID: 20825494 Ref: c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells. PMID: 20943948 Ref: Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer. PMID: 21053280 Ref: Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. PMID: 21152443 |
Ref: Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells. PMID: 20473900 Ref: Dasatinib: an anti-tumour agent via Src inhibition. PMID: 21226671 Ref: The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. PMID: 21282564 Ref: Src kinase pathway is involved in NFAT5-mediated S100A4 induction by hyperosmotic stress in colon cancer cells. PMID: 21289293 Ref: Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells. PMID: 21390316 Ref: Quantitative phospho-proteomic profiling of hepatocyte growth factor (HGF)-MET signaling in colorectal cancer. PMID: 21609022 Ref: Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. PMID: 21670084 Ref: Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells. PMID: 21774804 Ref: The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU. PMID: 21910008 Ref: ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression. PMID: 21937683 Ref: Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells. PMID: 21968138 Ref: Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734. PMID: 21994943 Ref: Genetic variability in EGFR, Src and HER2 and risk of colorectal adenoma and cancer. PMID: 22199994 Ref: SRC is dephosphorylated at tyrosine 530 in human colon carcinomas. PMID: 23467908 |
Ref: Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis. PMID: 21685945 Ref: Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death. PMID: 21785464 Ref: MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression. PMID: 21860426 Ref: Blockade of irradiation-induced autophagosome formation impairs proliferation but does not enhance cell death in HCT-116 human colorectal carcinoma cells. PMID: 22246348 Ref: A crucial role for Nox 1 in redox-dependent regulation of Wnt-beta-catenin signaling. PMID: 22278940 Ref: Src tyrosine kinase phosphorylation of nuclear receptor HNF4alpha correlates with isoform-specific loss of HNF4alpha in human colon cancer. PMID: 22308320 Ref: Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation. PMID: 22361730 Ref: High expression of IL-13 receptor alpha2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis. PMID: 22505647 Ref: Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells. PMID: 22517768 Ref: The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells. PMID: 22521508 Ref: Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib. PMID: 22553375 Ref: (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a cembrenolide diterpene from soft coral Lobophytum sp., inhibits growth and induces apoptosis in human colon cancer cells through reactive oxygen species generation. PMID: 22791152 Ref: c-Src antisense complexed with PAMAM denderimes decreases of c-Src expression and EGFR-dependent downstream genes in the human HT-29 colon cancer cell line. PMID: 22901200 Ref: Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner. PMID: 22941059 Ref: Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. PMID: 23023324 Ref: Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis. PMID: 23119029 Ref: Combined EGFR and c-Src antisense oligodeoxynucleotides encapsulated with PAMAM Denderimers inhibit HT-29 colon cancer cell proliferation. PMID: 23167414 Ref: Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo. PMID: 23259795 |
Ref: Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK. PMID: 22641216 Ref: Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14. PMID: 22710723 Ref: Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer. PMID: 22921465 Ref: Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1alpha,25-dihydroxyvitamin D3-responsive genes. PMID: 22944139 Ref: Irinotecan resistance is accompanied by upregulation of EGFR and Src signaling in human cancer models. PMID: 22973964 Ref: Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. PMID: 23027128 Ref: Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration. PMID: 23192271 Ref: Dual inhibition of alphaV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer. PMID: 23275294 Ref: Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists. PMID: 23276449 Ref: Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis. PMID: 23280667 Ref: DCC expression by neurons regulates synaptic plasticity in the adult brain. PMID: 23291093 Ref: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. PMID: 23333577 Ref: Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways. PMID: 23451189 Ref: CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a. PMID: 23533633 Ref: Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. PMID: 23585443 Ref: Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion. PMID: 23691193 Ref: FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer. PMID: 23696849 Ref: Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. PMID: 23792569 Ref: Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and beta-catenin. PMID: 23824743 Ref: Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells. PMID: 23900414 Ref: High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer. PMID: 23937454 Ref: Activation state-dependent interaction between Galphaq subunits and the Fhit tumor suppressor. PMID: 23947369 Ref: Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells. PMID: 24007880 Ref: MiR-424/503-mediated Rictor upregulation promotes tumor progression. PMID: 24244675 Ref: CRF2 signaling is a novel regulator of cellular adhesion and migration in colorectal cancer cells. PMID: 24260200 Ref: Global phosphotyrosine proteomics identifies PKCdelta as a marker of responsiveness to Src inhibition in colorectal cancer. PMID: 24260357 |
Ref: Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity. PMID: 23644655 Ref: The molecular rationale of Src inhibition in colorectal carcinomas. PMID: 23733480 Ref: The role of Src in colon cancer and its therapeutic implications. PMID: 24361441 Ref: Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. PMID: 24403062 Ref: Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation. PMID: 24407236 Ref: SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2. PMID: 24457997 Ref: Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. PMID: 24470239 Ref: Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. PMID: 24481553 Ref: Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids. PMID: 24520077 Ref: Cetuximab-induced MET activation acts as a novel resistance mechanism in colon cancer cells. PMID: 24714091 Ref: MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. PMID: 24735923 Ref: c-Src drives intestinal regeneration and transformation. PMID: 24788409 Ref: Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase. PMID: 24890449 Ref: [Analysis of oncogenic signaling induced by tyrosine kinases in tumors by SILAC-based quantitative proteomic approach]. PMID: 24939544 Ref: PELP1 suppression inhibits colorectal cancer through c-Src downregulation. PMID: 24967003 Ref: Proteogenomic characterization of human colon and rectal cancer. PMID: 25043054 Ref: Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways. PMID: 25111127 Ref: Epidermal growth factor stimulates nuclear factor-kappaB activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells. PMID: 25122478 Ref: Src activity is modulated by oxaliplatin and correlates with outcomes after hepatectomy for metastatic colorectal cancer. PMID: 25208577 Ref: Membrane androgen receptor down-regulates c-src-activity and beta-catenin transcription and triggers GSK-3beta-phosphorylation in colon tumor cells. PMID: 25301365 Ref: The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling. PMID: 25301722 Ref: Prognostic analysis of schistosomal rectal cancer. PMID: 25422211 |
Ref: Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer. PMID: 25323586 Ref: A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. PMID: 25351103 Ref: Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT-29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth. PMID: 25403643 Ref: Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/beta-catenin pathway. PMID: 25605242 Ref: PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer. PMID: 25617799 Ref: Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling. PMID: 25636878 Ref: A gp130-Src-YAP module links inflammation to epithelial regeneration. PMID: 25731159 Ref: Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells. PMID: 25794709 Ref: Human enhancer of filamentation 1-induced colorectal cancer cell migration: Role of serine phosphorylation and interaction with the breast cancer anti-estrogen resistance 3 protein. PMID: 25817040 Ref: Inhibitory effects of proton beam irradiation on integrin expression and signaling pathway in human colon carcinoma HT29 cells. PMID: 25845382 Ref: Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer. PMID: 25879875 Ref: Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib. PMID: 25889309 Ref: IL13 Receptor alpha2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis. PMID: 25896327 Ref: Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour. PMID: 26043921 Ref: Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRalpha/c-SRC/ERK1/2/NFkappaB/TP53 pathway: in vitro and in vivo studies. PMID: 26056802 Ref: Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells. PMID: 26318418 Ref: Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer. PMID: 26343543 Ref: Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran-pyrazole derivatives as anticancer agents. PMID: 26368040 Ref: Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer. PMID: 26416450 Ref: Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies. PMID: 27595061 |
Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. PMID: 26455323 Ref: MicroRNA-27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling. PMID: 26473412 Ref: DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53. PMID: 26494468 Ref: Dynamic Change of Polarity in Primary Cultured Spheroids of Human Colorectal Adenocarcinoma and Its Role in Metastasis. PMID: 26878211 Ref: Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line. PMID: 26919036 Ref: Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon. PMID: 27016416 Ref: Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells. PMID: 27086143 Ref: Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src. PMID: 27105527 Ref: Prognostic Impact of Microsatellite Instability in Colorectal Cancer Presenting With Mucinous, Signet-Ring, and Poorly Differentiated Cells. PMID: 27218096 Ref: Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and beta-catenin signaling pathways. PMID: 27422337 Ref: High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer. PMID: 27562229 Ref: Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: suppression of Src leading to thioredoxin up-regulation. PMID: 27613835 Ref: The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition. PMID: 27617642 Ref: Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. PMID: 27664007 Ref: Asporin enhances colorectal cancer metastasis through activating the EGFR/src/cortactin signaling pathway. PMID: 27705916 Ref: Claudin-1 promotes TNF-alpha-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells. PMID: 27742576 Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. PMID: 27756406 Ref: Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors. PMID: 27855221 Ref: Correction: Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src. PMID: 28074043 |
Ref: Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis. PMID: 27447856 Ref: HMGCS2 enhances invasion and metastasis via direct interaction with PPARalpha to activate Src signaling in colorectal cancer and oral cancer. PMID: 27816970 Ref: Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells. PMID: 27990641 Ref: Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. PMID: 28008134 Ref: Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis. PMID: 28068324 Ref: Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival. PMID: 28184012 Ref: MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway. PMID: 28186967 Ref: Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity. PMID: 28255353 Ref: Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer. PMID: 28280091 Ref: Phosphorylation of ETV4 at Ser73 by ERK kinase could block ETV4 ubiquitination degradation in colorectal cancer. PMID: 28373072 Ref: Overexpression of Srcin1 contributes to the growth and metastasis of colorectal cancer. PMID: 28393242 Ref: A crosstalk between muscarinic and CRF2 receptors regulates cellular adhesion properties of human colon cancer cells. PMID: 28432022 Ref: Systematic Identification and Competitive Disruption of Securin-Binding Partners in the Gene Diversity Space of Human Colorectal Cancer. PMID: 28477416 Ref: The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer. PMID: 28607598 Ref: Differentiation Affects the Release of Exosomes from Colon Cancer Cells and Their Ability to Modulate the Behavior of Recipient Cells. PMID: 28619275 Ref: TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways. PMID: 28624785 Ref: A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution. PMID: 28746882 Ref: Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine. PMID: 28784162 Ref: Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer. PMID: 28810597 Ref: Hypoxia-inducible factor 2alpha (HIF-2alpha) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. PMID: 28848049 Ref: Deep Phospho- and Phosphotyrosine Proteomics Identified Active Kinases and Phosphorylation Networks in Colorectal Cancer Cell Lines Resistant to Cetuximab. PMID: 28874695 Ref: Transcriptome-wide identification and competitive disruption of sacum-binding partners in human colorectal cancer. PMID: 28898789 Ref: SRC activates TAZ for intestinal tumorigenesis and regeneration. PMID: 28939028 Ref: Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model. PMID: 29091939 Ref: Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer. PMID: 29123263 Ref: Clinical Significance of Signet-Ring-Cell Colorectal Cancer as a Prognostic Factor. PMID: 29354606 Ref: [Two Cases of Colorectal Cancer with SRC Amplification]. PMID: 29394766 Ref: Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma. PMID: 29511478 |
Ref: 'MCC' protein interacts with E-cadherin and beta-catenin strengthening cell-cell adhesion of HCT116 colon cancer cells. PMID: 29035389 Ref: Transcriptome-wide identification and competitive disruption of sacum-binding partners in human colorectal cancer. PMID: 29328992 Ref: Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action. PMID: 29464048 Ref: BRAF and EGFR inhibitors synergize to increase cytotoxic effects and decrease stem cell capacities in BRAF(V600E)-mutant colorectal cancer cells. PMID: 29534162 Ref: Potential biomarkers for the early diagnosis of colorectal adenocarcinoma - transcriptomic analysis of four clinical stages. PMID: 29562499 Ref: Andrographolide Antagonizes TNF-alpha-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-kappaB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells. PMID: 29672044 Ref: Inflammatory genes are novel prognostic biomarkers for colorectal cancer. PMID: 29693170 Ref: IL-6 influences the polarization of macrophages and the formation and growth of colorectal tumor. PMID: 29707119 Ref: MicroRNA-181a promotes angiogenesis in colorectal cancer by targeting SRCIN1 to promote the SRC/VEGF signaling pathway. PMID: 29739921 Ref: Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology. PMID: 29740162 Ref: Hotspot KRAS exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells. PMID: 29755662 Ref: NDRG3 facilitates colorectal cancer metastasis through activating Src phosphorylation. PMID: 29844682 Ref: Dasatinib reduces 5-Fu-triggered apoptosis in colon carcinoma by directly modulating Src-dependent caspase-9 phosphorylation. PMID: 29844931 Ref: MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression. PMID: 29962093 Ref: Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP. PMID: 30009852 Ref: Annexin A2 overexpression associates with colorectal cancer invasiveness and TGF-ss induced epithelial mesenchymal transition via Src/ANXA2/STAT3. PMID: 30050103 Ref: Investigation into Enhancing Capecitabine Efficacy in Colorectal Cancer by Inhibiting Focal Adhesion Kinase Signaling. PMID: 30061234 Ref: TP53-dependence on the effect of doxorubicin and Src inhibitor combination therapy. PMID: 30124118 Ref: The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway. PMID: 30127519 Ref: Novel beta-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer. PMID: 30158525 Ref: Associations Among Histologic Characteristics and Patient Outcomes in Colorectal Carcinoma with a Mucinous Component. PMID: 30160323 Ref: The roles and mechanisms of G3BP1 in tumour promotion. PMID: 30207743 Ref: RasGRF2 promotes migration and invasion of colorectal cancer cells by modulating expression of MMP9 through Src/Akt/NF-kappaB pathway. PMID: 30359168 Ref: Inhibiting focal adhesion kinase: A potential target for enhancing therapeutic efficacy in colorectal cancer therapy. PMID: 30364839 |