Primary Site >> Liver Cancer
Gene >> SQSTM1
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Ref: Expression of ras and myc oncogenes in human hepatocellular carcinoma and non-neoplastic liver tissues. PMID: 2548435 |
Ref: Expression of ras and c-myc oncoproteins and hepatitis B surface antigen in human liver disease. PMID: 8462926 |
Ref: Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent. PMID: 10362795 Ref: Identification of p62, a phosphotyrosine independent ligand of p56lck kinase, as a major component of intracytoplasmic hyaline bodies in hepatocellular carcinoma. PMID: 10714219 |
Ref: Expression of a glypican-related 62-kDa antigen is decreased in hepatocellular carcinoma in correspondence to the grade of tumor differentiation. PMID: 11469688 Ref: De-novo humoral immune responses to cancer-associated autoantigens during transition from chronic liver disease to hepatocellular carcinoma. PMID: 11472419 Ref: Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis. PMID: 11549587 |
Ref: p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. PMID: 11786419 Ref: Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer. PMID: 12118381 Ref: Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinoma. PMID: 12849008 |
Ref: Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens. PMID: 12582023 Ref: Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. PMID: 14508512 Ref: [Significance of a novel fetal RNA-binding protein p62 expression in hepatocellular carcinoma]. PMID: 14514377 Ref: Recursive partitioning as an approach to selection of immune markers for tumor diagnosis. PMID: 14613989 |
Ref: Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells. PMID: 15618018 Ref: p62 Expression in primary carcinomas of the digestive system. PMID: 15793865 Ref: The diversity expression of p62 in digestive system cancers. PMID: 15886058 |
Ref: Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related? PMID: 16477590 |
Ref: Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma. PMID: 17067715 Ref: In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62. PMID: 17685470 |
Ref: Serotonin promotes tumor growth in human hepatocellular cancer. PMID: 20099302 Ref: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. PMID: 20173742 Ref: [Infection with hepatitis B virus enhances basal autophagy]. PMID: 21365919 |
Ref: Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype. PMID: 21145819 Ref: Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. PMID: 21482715 Ref: Potential role of p62 in tumor development. PMID: 21617386 Ref: iTRAQ-2DLC-ESI-MS/MS based identification of a new set of immunohistochemical biomarkers for classification of dysplastic nodules and small hepatocellular carcinoma. PMID: 21631109 Ref: Cross beta-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions. PMID: 21699779 Ref: Induction of an incomplete autophagic response by cancer-preventive geranylgeranoic acid (GGA) in a human hepatoma-derived cell line. PMID: 21787360 |
Ref: Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma. PMID: 22320446 Ref: Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. PMID: 22320909 Ref: Emerging role of autophagy during ischemia-hypoxia and reperfusion in hepatocellular carcinoma. PMID: 22469951 Ref: Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma. PMID: 22517429 Ref: Autophagic flux, supported by toll-like receptor 2 activity, defends against the carcinogenesis of hepatocellular carcinoma. PMID: 22996042 |
Ref: TLR2-dependent selective autophagy regulates NF-kappaB lysosomal degradation in hepatoma-derived M2 macrophage differentiation. PMID: 23175187 Ref: IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling. PMID: 23257922 Ref: Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation. PMID: 23360732 Ref: A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values. PMID: 23537217 Ref: Involvement of PPARgamma in the antitumoral action of cannabinoids on hepatocellular carcinoma. PMID: 23640460 Ref: Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models. PMID: 23664889 Ref: Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. PMID: 24098333 Ref: Blocking autophagic flux enhances matrine-induced apoptosis in human hepatoma cells. PMID: 24287900 Ref: Blocking Bcl-2 leads to autophagy activation and cell death of the HEPG2 liver cancer cell line. PMID: 24289588 |
Ref: Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma. PMID: 24220190 Ref: Impaired autophagy response in human hepatocellular carcinoma. PMID: 24369267 Ref: Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. PMID: 24401568 Ref: Phosphorylation of serine 349 of p62 in Alzheimer's disease brain. PMID: 24886973 Ref: [Feverfew lactone induces autophagic death of hepatocellular carcinoma SMMC 7721 cells]. PMID: 25286681 Ref: Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies. PMID: 25484079 |
Ref: Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients. PMID: 25043940 Ref: PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis. PMID: 25826083 Ref: Sann-Joong-Kuey-Jian-Tang induces autophagy in HepG2 cells via regulation of the phosphoinositide-3 kinase/Akt/mammalian target of rapamycin and p38 mitogen-activated protein kinase pathways. PMID: 25847489 Ref: Hepatoid carcinoma of the pancreas with lymphoid stroma: first description of the clinical, morphological, immunohistochemical, and molecular characteristics of an unusual pancreatic carcinoma. PMID: 25989715 Ref: IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype. PMID: 26426686 Ref: JNK-Bcl-2/Bcl-xL-Bax/Bak Pathway Mediates the Crosstalk between Matrine-Induced Autophagy and Apoptosis via Interplay with Beclin 1. PMID: 26516844 Ref: Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation. PMID: 26583321 |
Ref: p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. PMID: 27211490 Ref: Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation. PMID: 27239419 Ref: Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma. PMID: 27246794 Ref: p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. PMID: 27345495 Ref: A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells. PMID: 27367669 Ref: Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma. PMID: 27391348 Ref: p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. PMID: 27404485 Ref: Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and p62/Sequestosome-1-dependent Mitophagy. PMID: 27458013 Ref: A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. PMID: 27525972 Ref: p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies. PMID: 27526095 Ref: Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. PMID: 27653365 Ref: p62 in Liver Disease: Good Guy or Bad Guy? PMID: 27728799 Ref: p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. PMID: 27728806 Ref: Hepatocellular Carcinoma with Prominent Intracytoplasmic Inclusions: A Report of Two Cases. PMID: 27818805 Ref: Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. PMID: 27845389 |
Ref: Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis. PMID: 27885796 Ref: Chaperone-mediated autophagy compensates for impaired macroautophagy in the cirrhotic liver to promote hepatocellular carcinoma. PMID: 28402954 Ref: A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating alpha-Tubulin Expression. PMID: 28531143 Ref: Overexpression of dishevelled 2 is involved in tumor metastasis and is associated with poor prognosis in hepatocellular carcinoma. PMID: 28589433 Ref: Hepatoprotective Effect of Curcumin on Hepatocellular Carcinoma Through Autophagic and Apoptic Pathways. PMID: 28611265 Ref: Expression of P62 in hepatocellular carcinoma involving hepatitis B virus infection and aflatoxin B1 exposure. PMID: 28941211 Ref: Autophagy in the "inflammation-carcinogenesis" pathway of liver and HCC immunotherapy. PMID: 28987386 Ref: The lncRNA HULC functions as an oncogene by targeting ATG7 and ITGB1 in epithelial ovarian carcinoma. PMID: 29022892 Ref: Kaempferol induces autophagic cell death of hepatocellular carcinoma cells via activating AMPK signaling. PMID: 29156790 Ref: The autophagy marker LC3 strongly predicts immediate mortality after surgical resection for hepatocellular carcinoma. PMID: 29190884 Ref: Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. PMID: 29251796 |
Ref: Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2). PMID: 28980855 Ref: DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. PMID: 29311600 Ref: Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system. PMID: 29328502 Ref: Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy. PMID: 29385181 Ref: Aspirin induces Beclin-1-dependent autophagy of human hepatocellular carcinoma cell. PMID: 29408091 Ref: Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. PMID: 29548826 Ref: An autophagy-related gene expression signature for survival prediction in multiple cohorts of hepatocellular carcinoma patients. PMID: 29707114 Ref: Coronarin D induces apoptotic cell death through the JNK pathway in human hepatocellular carcinoma. PMID: 29968959 Ref: [Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2]. PMID: 30068847 Ref: Chaperone-Mediated Autophagy Promotes Beclin1 Degradation in Persistently Infected Hepatitis C Virus Cell Culture. PMID: 30075149 Ref: Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells. PMID: 30081711 Ref: DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. PMID: 30281815 Ref: [Study on Autophagy and Apoptosis Induced by Amiodarone Combined with Glycyrrhetinic Acid in HepG2 Cells]. PMID: 30378327 |