Primary Site >> Liver Cancer
Gene >> SPP1
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Ref: [Tumor microcirculation and selective enhancement of drug delivery--clinical applications based on pathophysiological experiments]. PMID: 10945016 |
Ref: Overexpression of osteopontin in hepatocellular carcinoma. PMID: 11940202 Ref: [Expression of osteopontin mRNA and its protein in colorectal cancer and liver metastatic tissues]. PMID: 12181091 Ref: [Expression and clinical significance of osteopontin in colorectal cancer and liver metastatic tissues]. PMID: 12487883 |
Ref: Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma. PMID: 12833464 Ref: [EGF/PI3K signaling pathway regulates the expression of osteopontin in liver cancer HepG2 cells]. PMID: 14703434 |
Ref: Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via phosphatidylinositol 3-kinase signaling pathway. PMID: 14716823 Ref: [Hepatitis/hepatocellular carcinoma and OPN/Eta-1]. PMID: 15453290 |
Ref: Aberrant expressions of annexin A10 short isoform, osteopontin and alpha-fetoprotein at chromosome 4q cooperatively contribute to progression and poor prognosis of hepatocellular carcinoma. PMID: 15754002 Ref: Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. PMID: 16047475 Ref: Elevated Serum Levels of Osteopontin in HCV-Associated Lymphoproliferative Disorders. PMID: 16177564 Ref: [The prognostic significance of preoperative plasma level of osteopontin in combination with intercellular adhesion molecule-1 for patients with hepatocellular carcinoma]. PMID: 16194354 Ref: Loss of E-cadherin mRNA and gain of osteopontin mRNA are useful markers for detecting early recurrence of HCV-related hepatocellular carcinoma. PMID: 16299806 Ref: Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C. PMID: 16344072 |
Ref: Correlation between genomic DNA copy number alterations and transcriptional expression in hepatitis B virus-associated hepatocellular carcinoma. PMID: 16750200 Ref: The prognostic significance of preoperative plasma levels of osteopontin in patients with hepatocellular carcinoma. PMID: 16786357 Ref: [Osteopontin as a potential biomarker of metastasis and recurrence for hepatocellular carcinoma]. PMID: 16831281 Ref: Elevated plasma osteopontin levels in patients with hepatocellular carcinoma. PMID: 16848813 Ref: Different molecular pathways determining extrahepatic and intrahepatic recurrences of hepatocellular carcinoma. PMID: 17016605 Ref: [Knocking down osteopontin expression by specific siRNA reduces the in vitro invasiveness of human hepatocellular carcinoma cells]. PMID: 17152482 |
Ref: [Osteopontin promotes the malignant phenotypes of human hepatocellular carcinoma cell line SMMC-7721]. PMID: 17244457 Ref: An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma. PMID: 17452979 Ref: SPP1 polymorphisms associated with HBV clearance and HCC occurrence. PMID: 17496055 Ref: Human macrophages promote the motility and invasiveness of osteopontin-knockdown tumor cells. PMID: 17545592 Ref: Identification of candidate biomarkers for hepatocellular carcinoma through pre-cancerous expression analysis in an HBx transgenic mouse. PMID: 18245957 |
Ref: Elevated plasma osteopontin level is predictive of cirrhosis in patients with hepatitis B infection. PMID: 17537188 Ref: Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. PMID: 17890765 Ref: Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data. PMID: 18337085 Ref: Thirty-kilodalton Tat-interacting protein suppresses tumor metastasis by inhibition of osteopontin transcription in human hepatocellular carcinoma. PMID: 18537194 Ref: RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer. PMID: 18549897 Ref: High-resolution analysis of genomic profiles of hepatocellular carcinoma cells with differential osteopontin expression. PMID: 18717013 Ref: Lentiviral-mediated miRNA against osteopontin suppresses tumor growth and metastasis of human hepatocellular carcinoma. PMID: 18972404 Ref: Osteopontin combined with CD44, a novel prognostic biomarker for patients with hepatocellular carcinoma undergoing curative resection. PMID: 18997126 Ref: Role of osteopontin and CD44s expression for patients with hepatocellular carcinoma undergoing liver transplantation or resection. PMID: 19010227 |
Ref: [Interference of osteopontin expression inhibits the invasion and metastasis of human hepatocellular carcinoma cell lines]. PMID: 19567019 Ref: Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization. PMID: 19783881 Ref: Osteopontin splice variants differentially modulate the migratory activity of hepatocellular carcinoma cell lines. PMID: 19885563 |
Ref: Genomic aberrations in hepatocellular carcinoma related to osteopontin expression detected by array-CGH. PMID: 19834740 Ref: Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression. PMID: 20034026 Ref: Inhibition of osteopontin reduces liver metastasis of human pancreatic cancer xenografts injected into the spleen in a mouse model. PMID: 20339989 Ref: Expression and prognostic significance of osteopontin and caspase-3 in hepatocellular carcinoma patients after curative resection. PMID: 20345480 Ref: A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase. PMID: 20364155 Ref: Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma. PMID: 20404171 Ref: Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis. PMID: 20414778 Ref: Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines. PMID: 20576283 Ref: Osteopontin, a single marker for predicting the prognosis of patients with tumor-node-metastasis stage I hepatocellular carcinoma after surgical resection. PMID: 20659235 Ref: Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma. PMID: 20890897 Ref: Clinical significance of plasma osteopontin level in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma. PMID: 21167394 Ref: Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression. PMID: 21190594 |
Ref: Osteopontin expression predicts overall survival after liver transplantation for hepatocellular carcinoma in patients beyond the Milan criteria. PMID: 20970216 Ref: Osteopontin promotes hepatocellular carcinoma invasion by up-regulating MMP-2 and uPA expression. PMID: 21104439 Ref: Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA. PMID: 21174062 Ref: Overexpression of osteopontin in hepatocellular carcinoma and its relationships with metastasis, invasion of tumor cells. PMID: 21188534 Ref: [Relative analysis of OPN and its related signal molecules in hepatocellular carcinoma]. PMID: 21272459 Ref: Specific expression of osteopontin and S100A6 in hepatocellular carcinoma. PMID: 21310450 Ref: Osteopontin as a key mediator for vasculogenic mimicry in hepatocellular carcinoma. PMID: 21512310 Ref: Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma. PMID: 21677331 Ref: Serum levels of beta-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma. PMID: 21701780 Ref: c-Met activation through a novel pathway involving osteopontin mediates oncogenesis by the transcription factor LSF. PMID: 21703197 Ref: [Identification of metastasis-related osteopontin expression and glycosylation in hepatocellular carcinoma]. PMID: 22525502 |
Ref: Prognostic significance of osteopontin in hepatocellular carcinoma: a meta-analysis. PMID: 21780114 Ref: Recurrence and poor prognosis following resection of small hepatitis B-related hepatocellular carcinoma lesions are associated with aberrant tumor expression profiles of glypican 3 and osteopontin. PMID: 21822558 Ref: Identification of osteopontin as a novel marker for early hepatocellular carcinoma. PMID: 21953299 Ref: Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model. PMID: 22241292 Ref: Global analysis of DNA methylation in early-stage liver fibrosis. PMID: 22281153 Ref: Hepatitis B virus X protein drives multiple cross-talk cascade loops involving NF-kappaB, 5-LOX, OPN and Capn4 to promote cell migration. PMID: 22355367 Ref: Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. PMID: 22444159 Ref: Interferon-alpha enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma. PMID: 22569271 Ref: The transcription factor LSF: a novel oncogene for hepatocellular carcinoma. PMID: 22679558 Ref: Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. PMID: 22807608 Ref: Hepatocellualar carcinoma serum markers. PMID: 22846859 Ref: Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers. PMID: 22912540 Ref: Breast cancer metastasis suppressor 1 regulates hepatocellular carcinoma cell apoptosis via suppressing osteopontin expression. PMID: 22927944 Ref: Association between Osteopontin and EGFR Expression with Clinicopathological Parameters in Hepatocellular Carcinoma. PMID: 23286449 |
Ref: Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma. PMID: 23079960 Ref: Canonical Wnt signaling pathway plays an essential role in N-methyl-N-nitrosurea induced gastric tumorigenesis of mice. PMID: 23117827 Ref: Postoperative serum osteopontin level is a novel monitor for treatment response and tumor recurrence after resection of hepatitis B-related hepatocellular carcinoma. PMID: 23203407 Ref: Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication. PMID: 23519646 Ref: Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma. PMID: 23651211 Ref: Effect of thalidomide on the proliferation of hepatoma cells assessed by osteopontin levels in nude mice. PMID: 23737889 Ref: Development and characterization of a reliable mouse model of colorectal cancer metastasis to the liver. PMID: 23748471 Ref: Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma. PMID: 23749381 Ref: Correlation and prognostic value of osteopontin and Bcl-2 in hepatocellular carcinoma patients after curative resection. PMID: 24065086 Ref: Effect of bone-marrow-derived mesenchymal stem cells on high-potential hepatocellular carcinoma in mouse models: an intervention study. PMID: 24079479 Ref: Mechanism of hepatitis C virus (HCV)-induced osteopontin and its role in epithelial to mesenchymal transition of hepatocytes. PMID: 24240095 Ref: SNPs in the promoter region of the osteopontin gene as a possible host factor for sex difference in hepatocellular carcinoma development in patients with HCV. PMID: 26201802 Ref: Clinical Significance of Plasma Osteopontin Level as a Biomarker of Hepatocellular Carcinoma. PMID: 27785253 |
Ref: Osteopontin: Versatile modulator of liver diseases. PMID: 23701387 Ref: Meta-analysis of the prognostic and diagnostic significance of serum/plasma osteopontin in hepatocellular carcinoma. PMID: 24247813 Ref: Combination of osteopontin with peritumoral infiltrating macrophages is associated with poor prognosis of early-stage hepatocellular carcinoma after curative resection. PMID: 24366422 Ref: Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies. PMID: 24464486 Ref: Role of hepatitis C virus induced osteopontin in epithelial to mesenchymal transition, migration and invasion of hepatocytes. PMID: 24498111 Ref: OPN and alphavbeta3 expression are predictors of disease severity and worse prognosis in hepatocellular carcinoma. PMID: 24498405 Ref: Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma. PMID: 24614035 Ref: Clinical utility of plasma glypican-3 and osteopontin as biomarkers of hepatocellular carcinoma. PMID: 24672660 Ref: Can combination of osteopontin and peritumor-infiltrating macrophages be a prognostic marker of early-stage hepatocellular carcinoma? PMID: 24812596 Ref: Importance of tumor/stroma interactions in prognosis of hepatocellular carcinoma. PMID: 24812604 Ref: Long-term outcome of laparoscopic hepatectomy in patients with hepatocellular carcinoma. PMID: 24901150 Ref: Screening candidate metastasis-associated genes in three-dimensional HCC spheroids with different metastasis potential. PMID: 24966965 Ref: Osteopontin enhances the expression of HOTAIR in cancer cells via IRF1. PMID: 24999034 Ref: OPN sesame. PMID: 25019071 Ref: Comparison osteopontin vs AFP for the diagnosis of HCC: a meta-analysis. PMID: 25034355 Ref: Serum anti-osteopontin autoantibody as a novel diagnostic and prognostic biomarker in patients with hepatocellular carcinoma. PMID: 25109745 Ref: Spatial localization of the JAG1/Notch1/osteopontin cascade modulates extrahepatic metastasis in hepatocellular carcinoma. PMID: 25176314 Ref: Significance of plasma osteopontin in diagnosis of hepatitis C virus-related hepatocellular carcinoma. PMID: 25249230 |
Ref: Osteopontin and latent-TGF beta binding-protein 2 as potential diagnostic markers for HBV-related hepatocellular carcinoma. PMID: 24803312 Ref: A novel oleanolic acid-loaded PLGA-TPGS nanoparticle for liver cancer treatment. PMID: 25026246 Ref: Intracellular Osteopontin inhibits toll-like receptor signaling and impedes liver carcinogenesis. PMID: 25398438 Ref: Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin. PMID: 25449435 Ref: Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma. PMID: 25652109 Ref: Multivariate analysis of molecular markers in peripheral blood associated with recurrence and metastasis of hepatocellular carcinoma. PMID: 25730089 Ref: Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin-NF-kappaB-HIF-1alpha pathway. PMID: 25749383 Ref: Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus infection. PMID: 25760884 Ref: Gene expression analysis for evaluation of potential biomarkers in hepatocellular carcinoma. PMID: 25862856 Ref: Effects of transforming growth factor beta-1 infected human bone marrow mesenchymal stem cells on high- and low-metastatic potential hepatocellular carcinoma. PMID: 26003220 Ref: Osteopontin Promotes Hepatic Progenitor Cell Expansion and Tumorigenicity via Activation of beta-Catenin in Mice. PMID: 26033745 Ref: Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening. PMID: 26122937 Ref: Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular carcinoma. PMID: 26189955 Ref: Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin beta1/GSK3beta/beta-Catenin Signaling Pathway. PMID: 26280346 Ref: Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC. PMID: 26397192 Ref: Plasma Osteopontin Level in Chronic Liver Disease and Hepatocellular Carcinoma. PMID: 26500684 Ref: Diagnostic and Prognostic Roles of Serum Osteopontin and Osteopontin Promoter Polymorphisms in Hepatitis B-related Hepatocellular Carcinoma. PMID: 26514514 Ref: Segment-specific targeting via RNA interference mediates down-regulation of OPN expression in hepatocellular carcinoma cells. PMID: 26600502 |
Ref: The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice. PMID: 26470729 Ref: Down-regulation of osteopontin mediates a novel mechanism underlying the cytostatic activity of TGF-beta. PMID: 26584547 Ref: Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity. PMID: 26676548 Ref: Osteopontin promotes epithelial-mesenchymal transition of hepatocellular carcinoma through regulating vimentin. PMID: 26824421 Ref: Clinicopathological Significance of Osteopontin in Cholangiocarcinoma Cases. PMID: 26838210 Ref: Diagnostic Performance of Alpha-Fetoprotein, Protein Induced by Vitamin K Absence, Osteopontin, Dickkopf-1 and Its Combinations for Hepatocellular Carcinoma. PMID: 26986465 Ref: Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma. PMID: 27219517 Ref: Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population. PMID: 27339170 Ref: Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B. PMID: 27391584 Ref: SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma. PMID: 27457505 Ref: Role of Osteopontin in Liver Diseases. PMID: 27570486 Ref: Comparative analysis of gene expression profiles of OPN signaling pathway in four kinds of liver diseases. PMID: 27659347 Ref: Osteopontin induces autophagy to promote chemo-resistance in human hepatocellular carcinoma cells. PMID: 27702661 Ref: Interleukin-6 enhances cancer stemness and promotes metastasis of hepatocellular carcinoma via up-regulating osteopontin expression. PMID: 27725896 Ref: Gene-expression Analysis Identifies Specific Patterns of Dysregulated Molecular Pathways and Genetic Subgroups of Human Hepatocellular Carcinoma. PMID: 27798868 Ref: Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice. PMID: 27888617 |
Ref: Serum Midkine and Osteopontin Levels as Diagnostic Biomarkers of Hepatocellular Carcinoma. PMID: 28243398 Ref: Diagnostic accuracy of osteopontin plus alpha-fetoprotein in the hepatocellular carcinoma: A meta-analysis. PMID: 28291627 Ref: Characterization of DAPK1 as a novel transcriptional target of BRMS1. PMID: 28339067 Ref: Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice. PMID: 28422962 Ref: Hepatocellular Carcinoma: a Comprehensive Review of Biomarkers, Clinical Aspects, and Therapy PMID: 28545181 Ref: Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients. PMID: 28702132 Ref: Osteopontin in hepatocellular carcinoma: A possible biomarker for diagnosis and follow-up. PMID: 28711012 Ref: Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing. PMID: 28745433 Ref: Osteopontin -- a promising biomarker for cancer therapy. PMID: 28819419 Ref: Up-regulation of brain-expressed X-linked 2 is critical for hepatitis B virus X protein-induced hepatocellular carcinoma development. PMID: 29029472 Ref: CCN3 is a therapeutic target relating enhanced stemness and coagulation in hepatocellular carcinoma. PMID: 29061995 Ref: Magnetic Resonance Gd-RGD Imaging Study of Hepatocellular Carcinoma with High and Low Metastatic Potential before and after Human Bone Marrow-derived Mesenchymal Stem Cell Intervention. PMID: 29067958 Ref: Delisheng induces antiproliferation and apoptosis effects in Hep3B cells via modulation of angiogenic proteins. PMID: 29163690 Ref: Improved treatment of early small hepatocellular carcinoma using sorafenib in combination with radiofrequency ablation. PMID: 29344133 |
Ref: Genome-wide DNA methylation analysis identifies candidate epigenetic markers and drivers of hepatocellular carcinoma. PMID: 27760737 Ref: C-C chemokine receptor type 1 mediates osteopontin-promoted metastasis in hepatocellular carcinoma. PMID: 29285854 Ref: Regulator of G-protein signaling 5 enhances portal vein invasion in hepatocellular carcinoma. PMID: 29434872 Ref: Osteopontin Regulates Hepatitis C Virus (HCV) Replication and Assembly by Interacting with HCV Proteins and Lipid Droplets and by Binding to Receptors alphaVbeta3 and CD44. PMID: 29669827 Ref: Evaluation of Osteopontin as a Biomarker in Hepatocellular Carcinomas in Egyptian Patients with Chronic HCV Cirrhosis PMID: 29693976 Ref: A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis. PMID: 29749642 Ref: Long-term prognostic impact of osteopontin and Dickkopf-related protein 1 in patients with hepatocellular carcinoma after hepatectomy. PMID: 29753515 Ref: Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular carcinoma. PMID: 29770948 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Supervised learning reveals circulating biomarker levels diagnostic of hepatocellular carcinoma in a clinically relevant model of non-alcoholic steatohepatitis; An OAD to NASH. PMID: 29944670 Ref: Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma. PMID: 30064482 Ref: Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells. PMID: 30107166 Ref: The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication. PMID: 30177680 Ref: Quantitative screening of serum protein biomarkers by reverse phase protein arrays. PMID: 30220970 Ref: A four-gene-based prognostic model predicts overall survival in patients with hepatocellular carcinoma. PMID: 30247807 Ref: Osteopontin promotes hepatocellular carcinoma progression via the PI3K/AKT/Twist signaling pathway. PMID: 30250599 |