Primary Site >> Stomach Cancer
Gene >> SPHK1
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Ref: Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. PMID: 12531554 |
Ref: 213Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G2 arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe. PMID: 17699730 |
Ref: Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. PMID: 18701480 |
Ref: Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. PMID: 19228740 |
Ref: Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. PMID: 20804754 |
Ref: Sphingosine kinase 1 is a relevant molecular target in gastric cancer. PMID: 21360847 Ref: [Relationship between sphingosine kinase 1 expression and tumor invasion, metastasis and prognosis in gastric cancer]. PMID: 22322056 |
Ref: miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1. PMID: 22450659 Ref: [Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro]. PMID: 22780925 |
Ref: [miR-124 suppresses cell proliferation and invasion in gastric carcinoma and its mechanism]. PMID: 24257299 |
Ref: SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. PMID: 25109605 Ref: A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells. PMID: 25556479 |
Ref: Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer. PMID: 26493335 |
Ref: Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. PMID: 27384994 |
Ref: Functional Genetic Variants in SPHK1 Affect Susceptibility to Gastric Cancer in a Chinese Population. PMID: 28879695 |
Ref: Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer. PMID: 30281914 |