Primary Site >> Colorectal Cancer
Gene >> SPHK1
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Ref: Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. PMID: 17361098 Ref: A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). PMID: 17991617 |
Ref: Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. PMID: 18701480 |
Ref: Role for sphingosine kinase 1 in colon carcinogenesis. PMID: 18824518 Ref: VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. PMID: 19219548 Ref: Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. PMID: 19240026 |
Ref: [Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms]. PMID: 21575515 Ref: Inhibition of SPHK1 suppresses phorbol 12-myristate 13-acetate-induced metastatic phenotype in colorectal cancer HT-29 cells. PMID: 22812190 |
Ref: Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D. PMID: 22024383 Ref: Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. PMID: 22684547 Ref: [The expression and clinical significance of SphK1 and nuclear factor-kappaB p65 in human colon carcinoma]. PMID: 22781898 |
Ref: Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. PMID: 23166225 Ref: Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules. PMID: 23232649 Ref: Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. PMID: 23273921 Ref: Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells. PMID: 23426175 Ref: [Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1]. PMID: 24054007 Ref: Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats. PMID: 24055189 |
Ref: Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. PMID: 24210073 Ref: Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population. PMID: 24572701 Ref: S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. PMID: 25061328 Ref: STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. PMID: 25132744 |
Ref: Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor. PMID: 25808826 Ref: MicroRNA-101 down-regulates sphingosine kinase 1 in colorectal cancer cells. PMID: 26071354 Ref: Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. PMID: 26337959 |
Ref: SphK1 promotes tumor cell migration and invasion in colorectal cancer. PMID: 26662312 Ref: Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543. PMID: 26775841 Ref: Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer. PMID: 26937138 Ref: Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer. PMID: 27050145 Ref: Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice. PMID: 27255176 Ref: miR-659-3p is involved in the regulation of the chemotherapy response of colorectal cancer via modulating the expression of SPHK1. PMID: 27725903 |
Ref: AT7867 Inhibits Human Colorectal Cancer Cells via AKT-Dependent and AKT-Independent Mechanisms. PMID: 28081222 Ref: SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells. PMID: 28405684 Ref: Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRalpha by K48/K63-linked polyubiquitination. PMID: 28465486 Ref: [Down-regulation of sphingosine kinase 1 (SphK1) enhances the chemosensitivity to cisplatin in human colon cancer RKO cells]. PMID: 28502300 Ref: Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer. PMID: 28991193 Ref: Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis. PMID: 29028945 |
Ref: Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice. PMID: 29643998 Ref: Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells. PMID: 29928348 Ref: De Novo Fatty Acid Synthesis Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer. PMID: 30154249 Ref: Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer. PMID: 30278948 Ref: Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelialmesenchymal transition mediated by the FAK/AKT/MMPs axis. PMID: 30365116 |