Primary Site >> Colorectal Cancer
Gene >> SPARC
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Modulation of extracellular matrix glycoproteins production by in vitro interacting conditions between rat colonic fibroblasts and tumoral cells. PMID: 1283839 |
Ref: Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin-3 and BM-40/SPARC genes. PMID: 7665251 |
Ref: Genomic organization and chromosomal mapping of SPARC-like 1, a gene down regulated in cancers. PMID: 11179481 Ref: Expression of SPARC/osteonectin/BM4O in the human gut: predominance in the stroma of the remodeling distal intestine. PMID: 11255229 |
Ref: Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer. PMID: 12209988 |
Ref: Tumor suppressor Smad4 mediates downregulation of the anti-adhesive invasion-promoting matricellular protein SPARC: Landscaping activity of Smad4 as revealed by a "secretome" analysis. PMID: 15188399 |
Ref: Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. PMID: 15763439 Ref: Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy. PMID: 15902309 Ref: Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. PMID: 16091733 |
Ref: Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis. PMID: 16733264 |
Ref: Synergism between vitamin D and secreted protein acidic and rich in cysteine-induced apoptosis and growth inhibition results in increased susceptibility of therapy-resistant colorectal cancer cells to chemotherapy. PMID: 17237289 Ref: Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. PMID: 17299058 Ref: Frequent inactivation of SPARC by promoter hypermethylation in colon cancers. PMID: 17397030 Ref: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. PMID: 17615082 Ref: A novel interaction between procaspase 8 and SPARC enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers. PMID: 17897953 Ref: Identification of gene signatures for invasive colorectal tumor cells. PMID: 17936523 |
Ref: SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response. PMID: 18458674 Ref: SPARC in cancer biology: its role in cancer progression and potential for therapy. PMID: 18849185 |
Ref: Tumor endothelium is characterized by a matrix remodeling signature. PMID: 19482697 |
Ref: Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC. PMID: 19236378 Ref: Identification of SPARC as a candidate target antigen for immunotherapy of various cancers. PMID: 20063317 Ref: Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53. PMID: 20164124 Ref: Relationship and prognostic significance of SPARC and VEGF protein expression in colon cancer. PMID: 20565704 |
Ref: Lymphovascular invasion of colorectal cancer is correlated to SPARC expression in the tumor stromal microenvironment. PMID: 21725199 Ref: SPARC, FOXP3, CD8 and CD45 correlation with disease recurrence and long-term disease-free survival in colorectal cancer. PMID: 21818290 |
Ref: A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise. PMID: 22851666 Ref: SPARC and DNA methylation: possible diagnostic and therapeutic implications in gastrointestinal cancers. PMID: 22939997 Ref: Exercise-induced SPARC prevents tumorigenesis of colon cancer. PMID: 23086830 Ref: Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination. PMID: 23128103 Ref: Stromal expression of SPARC in pancreatic adenocarcinoma. PMID: 23690170 Ref: Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis. PMID: 23862126 Ref: Parallel comparison of Illumina RNA-Seq and Affymetrix microarray platforms on transcriptomic profiles generated from 5-aza-deoxy-cytidine treated HT-29 colon cancer cells and simulated datasets. PMID: 23902433 Ref: [Physical activity in prevention and treatment of colon cancer]. PMID: 24697040 |
Ref: Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1. PMID: 24309322 Ref: Heterotopic ossification in metastatic colorectal carcinoma: case report with morphoproteomic insights into the histogenesis. PMID: 24695482 Ref: SPARC in Tumor Pathophysiology and as a Potential Therapeutic Target. PMID: 24947586 Ref: Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer. PMID: 25275062 |
Ref: Secreted protein acidic and rich in cysteine expression in human colorectal cancer predicts postoperative prognosis. PMID: 26044224 Ref: Genetic and Immunohistochemical Expression of Integrins ITGAV, ITGA6, and ITGA3 As Prognostic Factor for Colorectal Cancer: Models for Global and Disease-Free Survival. PMID: 26674523 |
Ref: Secreted protein acidic and rich in cysteine enhances the chemosensitivity of pancreatic cancer cells to gemcitabine. PMID: 26358255 Ref: Knockdown of SPOCK1 Inhibits the Proliferation and Invasion in Colorectal Cancer Cells by Suppressing the PI3K/Akt Pathway. PMID: 28281964 |
Ref: SPARC: As a prognostic biomarker in rectal cancer patients treated with chemo-radiotherapy. PMID: 28009327 Ref: Metastasis regulation by PPARD expression in cancer cells. PMID: 28097239 Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: Mesenchymal Stem Cells Induce Epithelial to Mesenchymal Transition in Colon Cancer Cells through Direct Cell-to-Cell Contact. PMID: 28433772 Ref: A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon Cancer. PMID: 28463901 Ref: Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer. PMID: 28583846 Ref: Colon cancer recurrenceassociated genes revealed by WGCNA coexpression network analysis. PMID: 28901407 Ref: hsa-miR-29c-3p regulates biological function of colorectal cancer by targeting SPARC. PMID: 29262657 |
Ref: Construction of key signal regulatory network in metastatic colorectal cancer. PMID: 29464057 Ref: Identification, isolation and characterization of human LGR5-positive colon adenoma cells. PMID: 29467240 Ref: Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma. PMID: 30175151 |