Primary Site >> Colorectal Cancer
Gene >> SOCS1
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Ref: Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. PMID: 14719065 Ref: Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients. PMID: 15074307 Ref: Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. PMID: 15386372 |
Ref: Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma. PMID: 16374457 Ref: IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. PMID: 16717119 |
Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. PMID: 17270239 Ref: Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. PMID: 17339237 Ref: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 17350669 Ref: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. PMID: 17372756 Ref: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. PMID: 17474983 Ref: Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. PMID: 17591929 Ref: MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. PMID: 17621591 Ref: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 17710160 Ref: Promoter methylation status of multiple genes in uveal melanoma. PMID: 17898258 Ref: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. PMID: 18084616 |
Ref: WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18084250 Ref: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. PMID: 18204436 Ref: LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18366060 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. PMID: 18628431 Ref: Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells. PMID: 18754879 Ref: CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. PMID: 18834226 Ref: Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype. PMID: 18983468 Ref: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PMID: 19002263 |
Ref: Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells. PMID: 18536936 Ref: CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. PMID: 18832519 Ref: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. PMID: 19107235 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. PMID: 19469017 Ref: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. PMID: 19470733 Ref: DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon cancer cells. PMID: 19551406 Ref: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. PMID: 19686742 Ref: Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. PMID: 19789368 Ref: Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. PMID: 19825961 Ref: Defective interleukin-4/Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3, SOCS-7, and CISH in colon cancer cells. PMID: 19929568 Ref: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. PMID: 20196786 |
Ref: Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. PMID: 20102720 Ref: PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 20200425 Ref: Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype. PMID: 20381446 Ref: Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. PMID: 21037082 |
Ref: Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. PMID: 20473920 Ref: MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. PMID: 21140203 Ref: 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer. PMID: 21185836 Ref: Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype. PMID: 21625944 Ref: B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PMID: 21738611 Ref: Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. PMID: 21806946 |
Ref: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. PMID: 21520296 Ref: Rhabdoid carcinoma of the colon: a distinct entity with a very aggressive behavior: a case report associated with a polyposis coli and review of the literature. PMID: 21791485 Ref: CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer. PMID: 22001634 Ref: Externalization of saw-tooth architecture in small serrated polyps implies the presence of methylation of IGFBP7. PMID: 22173745 Ref: Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1. PMID: 23019193 Ref: Human monocyte responses to lipopolysaccharide and 9-cis retinoic acid after laparoscopic surgery for colon cancer. PMID: 23094762 |
Ref: JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. PMID: 22121102 Ref: Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer. PMID: 23034738 Ref: Inhibitory role of Gas6 in intestinal tumorigenesis. PMID: 23430954 Ref: Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice. PMID: 24204690 Ref: The SOCS-1 -1478CA/del polymorphism is not associated with colorectal cancer or age at onset in Turkish subjects. PMID: 24460337 |
Ref: Comparison of CpG island methylator phenotype (CIMP) frequency in colon cancer using different probe- and gene-specific scoring alternatives on recommended multi-gene panels. PMID: 24466191 Ref: Suppressor of cytokine signaling 1 modulates invasion and metastatic potential of colorectal cancer cells. PMID: 24726456 Ref: CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer. PMID: 24859205 Ref: Lack of prognostic significance of SOCS-1 expression in colorectal adenocarcinomas. PMID: 25339048 |
Ref: The role of the CpG island methylator phenotype on survival outcome in colon cancer. PMID: 25167802 Ref: Nuclear maspin expression correlates with the CpG island methylator phenotype and tumor aggressiveness in colorectal cancer. PMID: 25973084 Ref: Tumour-promoting role of SOCS1 in colorectal cancer cells. PMID: 26391193 |
Ref: Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin. PMID: 26702772 Ref: Distinct features between MLH1-methylated and unmethylated colorectal carcinomas with the CpG island methylator phenotype: implications in the serrated neoplasia pathway. PMID: 26883113 Ref: Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: suppression of Src leading to thioredoxin up-regulation. PMID: 27613835 Ref: Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis. PMID: 27757304 |
Ref: The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases. PMID: 28469732 Ref: CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers. PMID: 28542846 Ref: Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway. PMID: 28591704 Ref: ASK1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis. PMID: 28931753 |
Ref: Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain? PMID: 29307628 Ref: Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. PMID: 29524208 Ref: Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy. PMID: 29921730 Ref: Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans. PMID: 29930328 |