Primary Site >> Colorectal Cancer
Gene >> SNAI2
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Ref: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. PMID: 14623871 |
Ref: Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients. PMID: 16773075 |
Ref: Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. PMID: 17016432 Ref: Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. PMID: 17363564 |
Ref: The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. PMID: 17599044 |
Ref: A molecular signature for Epithelial to Mesenchymal transition in a human colon cancer cell system is revealed by large-scale microarray analysis. PMID: 19340593 Ref: MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation. PMID: 19443654 Ref: Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. PMID: 19502595 Ref: Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. PMID: 19662683 |
Ref: Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. PMID: 19820419 Ref: Over-expression of Nanog predicts tumor progression and poor prognosis in colorectal cancer. PMID: 20026903 Ref: The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression. PMID: 20138990 Ref: Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells. PMID: 20332115 Ref: Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells. PMID: 20406951 Ref: Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. PMID: 20562906 Ref: Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin. PMID: 20622260 |
Ref: L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers. PMID: 21123622 Ref: Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3beta. PMID: 21303975 Ref: Slug expression enhances tumor formation in a noninvasive rectal cancer model. PMID: 21470622 Ref: Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. PMID: 21929751 |
Ref: Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon. PMID: 22363130 Ref: mRNA expression of adipocytokines and glucocorticoid-related genes are associated with downregulation of E-cadherin mRNA in colorectal adenocarcinomas. PMID: 22411584 Ref: Emerging evidence of epithelial-to-mesenchymal transition in lung carcinogenesis. PMID: 22452538 |
Ref: TGF-beta1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells. PMID: 22349829 Ref: Insights into cancer metastasis from a clinicopathologic perspective: Epithelial-Mesenchymal Transition is not a necessary step. PMID: 22833228 Ref: Differences in the expression of epithelial-mesenchymal transition related molecules between primary tumors and pulmonary metastatic tumors in colorectal cancer. PMID: 23052737 Ref: Isolation and characterization of calcium sensing receptor null cells: a highly malignant and drug resistant phenotype of colon cancer. PMID: 23055106 Ref: A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression. PMID: 23059759 Ref: Beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells. PMID: 23174221 Ref: Extracellular signal-regulated kinase and Akt activation play a critical role in the process of hepatocyte growth factor-induced epithelial-mesenchymal transition. PMID: 23229794 Ref: MTA-1 expression is associated with metastasis and epithelial to mesenchymal transition in colorectal cancer cells. PMID: 23371285 Ref: Epithelial-mesenchymal transition (EMT) induced by TNF-alpha requires AKT/GSK-3beta-mediated stabilization of snail in colorectal cancer. PMID: 23431386 Ref: Vitamin D receptor and retinoid X receptor alpha status and vitamin D insufficiency in models of murine colitis. PMID: 23585425 Ref: In vitro treatment of carcinoma cell lines with pancreatic (pro)enzymes suppresses the EMT programme and promotes cell differentiation. PMID: 23677639 Ref: Epithelial-mesenchymal transition and its role in the pathogenesis of colorectal cancer. PMID: 23803016 Ref: Knockdown of Slug by RNAi inhibits the proliferation and invasion of HCT116 colorectal cancer cells. PMID: 23900394 Ref: Increased expression of Slug and Vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer. PMID: 24001454 Ref: c-Kit is suppressed in human colon cancer tissue and contributes to L1-mediated metastasis. PMID: 24008320 Ref: Epithelial-mesenchymal transition associates with maintenance of stemness in spheroid-derived stem-like colon cancer cells. PMID: 24039918 Ref: Shikonin inhibits thyroid cancer cell growth and invasiveness through targeting major signaling pathways. PMID: 24106286 |
Ref: Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis. PMID: 23752192 Ref: Slug expression inhibits calcitriol-mediated sensitivity to radiation in colorectal cancer. PMID: 23996472 Ref: Activation of AKT signaling promotes epithelial-mesenchymal transition and tumor growth in colorectal cancer cells. PMID: 24000138 Ref: Overexpression of integrin-linked kinase (ILK) promotes migration and invasion of colorectal cancer cells by inducing epithelial-mesenchymal transition via NF-kappaB signaling. PMID: 24360977 Ref: MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma. PMID: 24402783 Ref: Angiogenic sprouting is regulated by endothelial cell expression of Slug. PMID: 24554431 Ref: Multiple effects of the special AT-rich binding protein 1 (SATB1) in colon carcinoma. PMID: 24729451 Ref: Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PMID: 24760019 Ref: PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer. PMID: 24837077 Ref: The ethanolic extract of bark from Salix aegyptiaca L. inhibits the metastatic potential and epithelial to mesenchymal transition of colon cancer cell lines. PMID: 25175673 Ref: Enteric pathogens and cellular transformation: bridging the gaps. PMID: 25216513 Ref: Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT. PMID: 25238234 Ref: SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression. PMID: 25249558 Ref: Synergistic association of Notch and NFkappaB signaling and role of Notch signaling in modulating epithelial to mesenchymal transition in colorectal adenocarcinoma. PMID: 25257945 |
Ref: SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775 Ref: Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. PMID: 25434997 Ref: Cell-surface Vimentin: A mislocalized protein for isolating csVimentin(+) CD133(-) novel stem-like hepatocellular carcinoma cells expressing EMT markers. PMID: 25487874 Ref: Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition. PMID: 25750173 Ref: Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro. PMID: 25832648 Ref: Restoration of the anti-proliferative and anti-migratory effects of 1,25-dihydroxyvitamin D by silibinin in vitamin D-resistant colon cancer cells. PMID: 25846868 Ref: Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas. PMID: 25873367 Ref: Notch-1 promotes stemness and epithelial to mesenchymal transition in colorectal cancer. PMID: 25914224 Ref: Immune response gene expression in colorectal cancer carries distinct prognostic implications according to tissue, stage and site: a prospective retrospective translational study in the context of a hellenic cooperative oncology group randomised trial. PMID: 25970543 Ref: Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells. PMID: 26045985 Ref: Up-regulation of microRNA-302a inhibited the proliferation and invasion of colorectal cancer cells by regulation of the MAPK and PI3K/Akt signaling pathways. PMID: 26191138 Ref: Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer. PMID: 26379394 Ref: The Hedgehog Inhibitor Cyclopamine Reduces beta-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells. PMID: 26393651 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 |
Ref: Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer. PMID: 26603055 Ref: OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors. PMID: 26619963 Ref: By moonlighting in the nucleus, villin regulates epithelial plasticity. PMID: 26658611 Ref: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2. PMID: 26707141 Ref: Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells. PMID: 26752044 Ref: IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer. PMID: 26840943 Ref: The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. PMID: 26876487 Ref: Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells. PMID: 26883103 Ref: Physcion 8-O-beta-glucopyranoside prevents hypoxia-induced epithelial-mesenchymal transition in colorectal cancer HCT116 cells by modulating EMMPRIN. PMID: 26925795 Ref: Role of cancer stem cells in racial disparity in colorectal cancer. PMID: 26990997 Ref: Overexpression of Livin promotes migration and invasion of colorectal cancer cells by induction of epithelial-mesenchymal transition via NF-kappaB activation. PMID: 27013894 Ref: Lysyl Oxidase (LOX) Transcriptionally Regulates SNAI2 Expression and TIMP4 Secretion in Human Cancers. PMID: 27029493 Ref: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. PMID: 27058823 Ref: Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer. PMID: 27150059 Ref: microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway. PMID: 27191497 Ref: Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO. PMID: 27259250 Ref: Twist1 and Slug mediate H2AX-regulated epithelial-mesenchymal transition in breast cells. PMID: 27315462 Ref: Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation. PMID: 27369075 Ref: Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer. PMID: 27573895 Ref: The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition. PMID: 27617642 |
Ref: FERMT1 mediates epithelial-mesenchymal transition to promote colon cancer metastasis via modulation of beta-catenin transcriptional activity. PMID: 27641329 Ref: Tumor budding at the invasive front of colorectal cancer may not be associated with the epithelial-mesenchymal transition. PMID: 27836787 Ref: Loss of periplakin expression is associated with the tumorigenesis of colorectal carcinoma. PMID: 28068625 Ref: Long non-coding RNA CCAT2 is associated with poor prognosis in hepatocellular carcinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial-mesenchymal transition. PMID: 28280353 Ref: Effect of antitumor drugs in low concentrationson the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro. PMID: 28361849 Ref: SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells. PMID: 28405684 Ref: Peroxiredoxin 5 promotes the epithelial-mesenchymal transition in colon cancer. PMID: 28431931 Ref: Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/beta-catenin/Slug pathway. PMID: 28542126 Ref: Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression. PMID: 28680090 Ref: SATB2/beta-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer. PMID: 28887549 Ref: Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators. PMID: 29107070 Ref: Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-kappaB/slug/E-cadherin pathway. PMID: 29202800 |
Ref: Ecotropic viral integration site 1 promotes metastasis independent of epithelial mesenchymal transition in colon cancer cells. PMID: 29339729 Ref: Modulation of the colon cancer cell phenotype by pro-inflammatory macrophages: A preclinical model of surgery-associated inflammation and tumor recurrence. PMID: 29462209 Ref: Smad4 and epithelial-mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical study. PMID: 29468299 Ref: HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer. PMID: 29504907 Ref: Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells. PMID: 29524226 Ref: Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression. PMID: 29604394 Ref: Lgr5+CD44+EpCAM+ Strictly Defines Cancer Stem Cells in Human Colorectal Cancer. PMID: 29627827 Ref: DUOX2-mediated production of reactive oxygen species induces epithelial mesenchymal transition in 5-fluorouracil resistant human colon cancer cells. PMID: 29715584 Ref: MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the TGFbeta/SMAD Signaling Pathway in Colorectal Cancer Metastasis. PMID: 29719292 Ref: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin. PMID: 29921293 Ref: Korean Red Ginseng extract reduces hypoxia-induced epithelial-mesenchymal transition by repressing NF-kappaB and ERK1/2 pathways in colon cancer. PMID: 29983610 Ref: Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells. PMID: 30060617 Ref: Analysis of the expression of cancer-associated fibroblast- and EMT-related proteins in submucosal invasive colorectal cancer. PMID: 30087711 Ref: Cisatracurium Retards Cell Migration and Invasion Upon Upregulation of p53 and Inhibits the Aggressiveness of Colorectal Cancer. PMID: 30108509 Ref: HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways. PMID: 30231922 Ref: Jiedu Sangen Decoction Inhibits Migration and Invasion of Colon Cancer SW480 Cells via Suppressing Epithelial Mesenchymal Transition. PMID: 30356400 |