Primary Site >> Stomach Cancer
Gene >> SMAD4
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Ref: Juvenile Polyposis Syndrome PMID: 20301642 |
Ref: Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. PMID: 8957088 |
Ref: Analysis of the DPC4 gene in gastric carcinoma. PMID: 9197522 Ref: Inactivation of Smad4 in gastric carcinomas. PMID: 9331080 |
Ref: Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. PMID: 10708952 |
Ref: Preserved Smad4 expression in the transforming growth factor beta signaling pathway is a favorable prognostic factor in patients with advanced gastric cancer. PMID: 11234879 Ref: Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells. PMID: 11716479 |
Ref: Preferential loss of Fhit expression in signet-ring cell and Krukenberg subtypes of gastric cancer. PMID: 12218081 Ref: Different pattern of allelic loss in Epstein-Barr virus-positive gastric cancer with emphasis on the p53 tumor suppressor pathway. PMID: 12368194 |
Ref: Tumour suppressor gene expression correlates with gastric cancer prognosis. PMID: 12692839 Ref: Aberrant signaling of TGF-beta1 by the mutant Smad4 in gastric cancer cells. PMID: 12860278 Ref: Interferon-gamma suppresses transforming growth factor-beta-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model. PMID: 14586410 Ref: Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis. PMID: 14678019 |
Ref: Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. PMID: 15014022 Ref: Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas. PMID: 15033661 Ref: The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. PMID: 15235019 Ref: E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. PMID: 15288293 Ref: Concomitant overexpression of cyclooxygenase-2 in HER-2-positive on Smad4-reduced human gastric carcinomas is associated with a poor patient outcome. PMID: 15501972 |
Ref: Orofacial and gastrointestinal hyperplasia and neoplasia in smad4+/- and elf+/-/smad4+/- mutant mice. PMID: 15610403 Ref: Clinicopathologic and protein expression differences between cardia carcinoma and noncardia carcinoma of the stomach. PMID: 15726543 Ref: Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma. PMID: 15736060 Ref: Gastric juvenile polyposis associated with germline SMAD4 mutation. PMID: 15754356 Ref: Nuclear factor-kappaB activation correlates with better prognosis and Akt activation in human gastric cancer. PMID: 15814628 Ref: The role of PRAJA and ELF in TGF-beta signaling and gastric cancer. PMID: 16096365 Ref: Inactivation of ELF/TGF-beta signaling in human gastrointestinal cancer. PMID: 16158060 Ref: Histological and immunohistochemical study of composite neuroendocrine-exocrine carcinomas of the stomach. PMID: 16167538 |
Ref: TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF. PMID: 16650383 Ref: Selective inhibition of cell growth by activin in SNU-16 cells. PMID: 16718778 |
Ref: Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells. PMID: 16987993 Ref: Rebamipide inhibits gastric cancer cell growth. PMID: 17171453 Ref: Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression. PMID: 17200344 Ref: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. PMID: 17376510 Ref: Constitutive phosphorylation of the FOXO1A transcription factor as a prognostic variable in gastric cancer. PMID: 17491598 Ref: High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome. PMID: 17873119 |
Ref: Image of the month. Gastric juvenile polyposis (GJP) in germline SMAD4 mutation accompanied by gastric cancer. PMID: 18347281 Ref: Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. PMID: 18498120 Ref: Immunohistochemical expression of P15 (INK4B) and SMAD4 in advanced gastric cancer. PMID: 18507057 Ref: Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer. PMID: 18798223 Ref: Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence. PMID: 18830930 |
Ref: Smad4/Smad7 balance: a role of tumorigenesis in gastric cancer. PMID: 19341727 Ref: Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3. PMID: 19350572 Ref: c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma. PMID: 19594546 Ref: [Correlations of TGF-betaRII, Smad4 and Smad7 expression to clinicopathologic characteristics and prognosis of gastric cancer]. PMID: 19624886 Ref: TGF-beta promotes invasion and metastasis of gastric cancer cells by increasing fascin1 expression via ERK and JNK signal pathways. PMID: 19657566 |
Ref: Constitutive activation of glycogen synthase kinase-3beta correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer. PMID: 20704706 Ref: Genetic variations in the SMAD4 gene and gastric cancer susceptibility. PMID: 21105199 |
Ref: Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene. PMID: 21593157 Ref: Gastric cancer: basic aspects. PMID: 21896084 |
Ref: Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis. PMID: 22020746 Ref: Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting betacatenin signaling. PMID: 22710759 Ref: Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells. PMID: 22791809 Ref: Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-beta signalling pathway. PMID: 22821565 Ref: Genetic testing by cancer site: stomach. PMID: 22846738 Ref: Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes. PMID: 23084251 |
Ref: Functional outcomes by reconstruction technique following laparoscopic proximal gastrectomy for gastric cancer: double tract versus jejunal interposition. PMID: 24468278 Ref: A study of Smad4 and Smad7 expression in surgically resected samples of gastric adenocarcinoma and their correlation with clinicopathological parameters and patient survival. PMID: 24659668 Ref: Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. PMID: 24784840 Ref: Baicalein inhibits migration and invasion of gastric cancer cells through suppression of the TGF-beta signaling pathway. PMID: 25109410 Ref: Meta-analysis of the prognostic value of smad4 immunohistochemistry in various cancers. PMID: 25333693 Ref: High-throughput sequencing and copy number variation detection using formalin fixed embedded tissue in metastatic gastric cancer. PMID: 25372287 |
Ref: Establishment and characterization of metastatic gastric cancer cell lines from murine gastric adenocarcinoma lacking Smad4, p53, and E-cadherin. PMID: 25307412 Ref: Tumor profiling of gastric and esophageal carcinoma reveal different treatment options. PMID: 25778705 Ref: Pyloric gland adenoma: a histologic, immunohistochemical and molecular genetic study of 23 cases. PMID: 26421956 Ref: Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2. PMID: 26494556 |
Ref: Differences in TGF-beta1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer. PMID: 26846663 Ref: Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer. PMID: 26869189 Ref: Comprehensive molecular portrait using next generation sequencing of resected intestinal-type gastric cancer patients dichotomized according to prognosis. PMID: 26961069 Ref: miR-148a downregulates the expression of transforming growth factor-beta2 and SMAD2 in gastric cancer. PMID: 26983401 Ref: Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development. PMID: 27006499 Ref: Smad2/3/4 Pathway Contributes to TGF-beta-Induced MiRNA-181b Expression to Promote Gastric Cancer Metastasis by Targeting Timp3. PMID: 27383203 Ref: Epstein-Barr virus BARF1-induced NFkappaB/miR-146a/SMAD4 alterations in stomach cancer cells. PMID: 27438138 Ref: Prophylactic total gastrectomy in the management of hereditary tumor syndromes. PMID: 27682646 Ref: miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expression. PMID: 27685626 Ref: hsa-miR-376c-3p Regulates Gastric Tumor Growth Both In Vitro and In Vivo. PMID: 27965982 |
Ref: Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells. PMID: 27922669 Ref: Upregulation of microRNA-574-3p in a human gastric cancer cell line AGS by TGF-beta1. PMID: 28042090 Ref: Proteogenomic analysis of NCC-S1M, a gastric cancer stem cell-like cell line that responds to anti-PD-1. PMID: 28153736 Ref: miR196a5p modulates gastric cancer stem cell characteristics by targeting Smad4. PMID: 28440445 Ref: Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection. PMID: 28512631 Ref: Genomic Profiling of Small-Bowel Adenocarcinoma. PMID: 28617917 |
Ref: Gastric poorly cohesive carcinoma: a correlative study of mutational signatures and prognostic significance based on histopathological subtypes. PMID: 28873240 Ref: miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway. PMID: 29103082 Ref: Multi-omics analysis identifies pathways and genes involved in diffuse-type gastric carcinogenesis induced by E-cadherin, p53, and Smad4 loss in mice. PMID: 29528141 Ref: Smad4/Fascin index is highly prognostic in patients with diffuse type EBV-associated gastric cancer. PMID: 29572117 Ref: ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis. PMID: 29654155 Ref: Non-familial juvenile polyposis of the stomach with gastric cancers: a case report. PMID: 30043121 Ref: Functional evaluations comparing the double-tract method and the jejunal interposition method following laparoscopic proximal gastrectomy for gastric cancer: an investigation including laparoscopic total gastrectomy. PMID: 30159780 |