Primary Site >> Colorectal Cancer
Gene >> SMAD2
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Ref: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. PMID: 8752209 |
Ref: Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60. PMID: 9264367 Ref: Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma. PMID: 9288786 Ref: Molecular biology of colorectal cancer. PMID: 9438104 |
Ref: Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. PMID: 9464505 Ref: Mutation analysis of the Smad2 gene in human colon cancers using genomic DNA and intron primers. PMID: 9635866 Ref: Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia. PMID: 9665198 Ref: Smad3 mutant mice develop metastatic colorectal cancer. PMID: 9753318 Ref: Smad4 (DPC4)--a potent tumour suppressor? PMID: 9862572 |
Ref: Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. PMID: 10340381 Ref: Expression of Smad proteins in human colorectal cancer. PMID: 10389752 Ref: Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion. PMID: 10438456 Ref: Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome. PMID: 10446110 Ref: Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. PMID: 10543255 Ref: Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. PMID: 10559252 Ref: Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers. PMID: 10665650 Ref: Sequence of molecular genetic events in colorectal tumorigenesis. PMID: 10772417 |
Ref: DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination. PMID: 10698524 Ref: A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. PMID: 10789724 Ref: No SMAD4 hypermethylation in colorectal cancer. PMID: 10993648 Ref: The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression. PMID: 11040453 |
Ref: Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. PMID: 11215281 Ref: Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7. PMID: 11391794 Ref: SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway. PMID: 11481457 Ref: Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability. PMID: 11553622 |
Ref: No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. PMID: 12183405 Ref: Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. PMID: 12208849 Ref: High resolution analysis of chromosome 18 alterations in ulcerative colitis-related colorectal cancer. PMID: 12237237 Ref: [Genetic pathways in colorectal cancer: interest for the pathologist]. PMID: 12410150 |
Ref: Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene. PMID: 12557227 Ref: Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus. PMID: 12584607 Ref: SMAD7 is a prognostic marker in patients with colorectal cancer. PMID: 12584741 Ref: TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. PMID: 12618756 Ref: Role of Smad4 (DPC4) inactivation in human cancer. PMID: 12821112 Ref: Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer. PMID: 12866583 Ref: Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis. PMID: 12967141 Ref: Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29. PMID: 14520001 |
Ref: Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction. PMID: 14647410 Ref: Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. PMID: 14715079 Ref: Transforming growth factor-beta signaling is differentially inhibited by Smad2D450E and Smad3D407E. PMID: 14720321 Ref: alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression. PMID: 15374947 Ref: Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes. PMID: 15520171 |
Ref: Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis. PMID: 15665291 Ref: TGF-beta signaling in colon cancer cells. PMID: 15711891 Ref: Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-beta1/Smad pathway. PMID: 15963949 Ref: Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer. PMID: 16015041 Ref: Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. PMID: 16135802 |
Ref: Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells. PMID: 16288847 |
Ref: Genetic alterations of the TGF-beta signaling pathway in colorectal cancer cell lines: a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation. PMID: 16828225 Ref: Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta. PMID: 17893910 |
Ref: Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases. PMID: 18219106 Ref: Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival. PMID: 18425078 Ref: The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. PMID: 18425817 Ref: TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells. PMID: 18769113 Ref: Smad7 induces hepatic metastasis in colorectal cancer. PMID: 18781153 Ref: SMAD2 and the relationship of colorectal cancer to inflammatory bowel disease. PMID: 18949743 Ref: Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis. PMID: 18959792 |
Ref: Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. PMID: 19147584 Ref: Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer. PMID: 19531654 Ref: RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells. PMID: 19571605 Ref: Promoter-wide analysis of Smad4 binding sites in human epithelial cells. PMID: 19686287 |
Ref: Transforming growth factor-beta suppressed Id-1 Expression in a smad3-dependent manner in LoVo cells. PMID: 19798702 Ref: Distinct genetic alterations in colorectal cancer. PMID: 20126641 Ref: Vectorial TGFbeta signaling in polarized intestinal epithelial cells. PMID: 20432436 Ref: Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. PMID: 20622003 Ref: Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. PMID: 20732443 |
Ref: Genetic variation in the TGF-beta signaling pathway and colon and rectal cancer risk. PMID: 21068203 Ref: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer. PMID: 21365634 Ref: The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways. PMID: 21473864 Ref: Chemopreventive effect of ERbeta-Selective agonist on intestinal tumorigenesis in Apc(Min/+) mice. PMID: 21480389 Ref: Protein kinase CK2alpha is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes. PMID: 21702981 Ref: Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. PMID: 21978709 Ref: Enhancement of TGF-beta signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer. PMID: 21998011 |
Ref: Direct inhibition of the transforming growth factor-beta pathway by protein-bound polysaccharide through inactivation of Smad2 signaling. PMID: 22034928 Ref: Transforming growth factor-beta1 induces glutathione peroxidase-1 and protects from H2O2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1alpha pathway. PMID: 22307228 Ref: Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters. PMID: 22452939 Ref: Toxicarioside A inhibits tumor growth and angiogenesis: involvement of TGF-beta/endoglin signaling. PMID: 23209720 |
Ref: BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor beta (TGF-beta1) in colorectal tumour cells. PMID: 23108401 Ref: SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. PMID: 23139211 Ref: Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFbeta1-targeting peptides P17 and P144. PMID: 23153552 Ref: Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer. PMID: 23426176 Ref: TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. PMID: 23536895 Ref: S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer. PMID: 23661436 Ref: APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-beta1/ERK signaling pathway in human colorectal cancer cells. PMID: 23867993 Ref: Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. PMID: 23886856 |
Ref: High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PMID: 24427302 Ref: Masking epistasis between MYC and TGF-beta pathways in antiangiogenesis-mediated colon cancer suppression. PMID: 24627270 Ref: Identification of a characteristic copy number alteration profile by high-resolution single nucleotide polymorphism arrays associated with metastatic sporadic colorectal cancer. PMID: 24668684 Ref: Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway. PMID: 24696849 Ref: N-Hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells. PMID: 24727557 Ref: DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/beta-catenin signaling pathway genes. PMID: 24811787 Ref: S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-beta signaling pathway in cancer cells. PMID: 24970681 Ref: Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2. PMID: 25166914 Ref: PDGF receptor-alpha promotes TGF-beta signaling in hepatic stellate cells via transcriptional and posttranscriptional regulation of TGF-beta receptors. PMID: 25169976 Ref: Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT. PMID: 25238234 |
Ref: Pien Tze Huang inhibits metastasis of human colorectal carcinoma cells via modulation of TGF-beta1/ZEB/miR-200 signaling network. PMID: 25422078 Ref: Pien Tze Huang inhibits liver metastasis by targeting TGF-beta signaling in an orthotopic model of colorectal cancer. PMID: 25653118 Ref: Transforming Growth Factor beta Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2. PMID: 25736321 Ref: Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer. PMID: 25889203 Ref: Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer. PMID: 25908723 Ref: Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-beta/Smad2/3 signaling. PMID: 25934251 Ref: Crosstalk between Hippo and TGFbeta: Subcellular Localization of YAP/TAZ/Smad Complexes. PMID: 25937570 Ref: Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era. PMID: 25974029 Ref: Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy. PMID: 25980495 Ref: Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer. PMID: 26328044 Ref: New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding. PMID: 26370966 |
Ref: GDF15 promotes EMT and metastasis in colorectal cancer. PMID: 26497212 Ref: Modulation of transforming growth factorbeta signaling transducers in colon adenocarcinoma cells induced by staphylococcal enterotoxin B. PMID: 26647993 Ref: Tolfenamic acid downregulates beta-catenin in colon cancer. PMID: 27089389 Ref: Transforming Growth Factor beta Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer. PMID: 27330076 Ref: Pregnancy-specific glycoprotein 9 (PSG9), a driver for colorectal cancer, enhances angiogenesis via activation of SMAD4. PMID: 27528036 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 |
Ref: Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains. PMID: 27222126 Ref: Cholest-4-en-3-one attenuates TGF-beta responsiveness by inducing TGF-beta receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells. PMID: 27401208 Ref: TGF-beta1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells. PMID: 27840994 Ref: Microcystin-LR promotes epithelial-mesenchymal transition in colorectal cancer cells through PI3-K/AKT and SMAD2. PMID: 27856280 Ref: Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration. PMID: 28049506 Ref: Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. PMID: 28106826 Ref: Construction of a multiplex mutation hot spot PCR panel: the first step towards colorectal cancer genotyping on the GS Junior platform. PMID: 28243320 Ref: JianPi JieDu Recipe Inhibits Epithelial-to-Mesenchymal Transition in Colorectal Cancer through TGF-beta/Smad Mediated Snail/E-Cadherin Expression. PMID: 28299321 Ref: Smad4 Inhibits VEGF-A and VEGF-C Expressions via Enhancing Smad3 Phosphorylation in Colon Cancer. PMID: 28445620 Ref: A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer. PMID: 28551381 Ref: Anti-fibrogenic effect of PPAR-gamma agonists in human intestinal myofibroblasts. PMID: 28592228 Ref: Significance of positive and inhibitory regulators in the TGF-beta signaling pathway in colorectal cancers. PMID: 28601657 Ref: Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. PMID: 28714374 Ref: Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance. PMID: 28819438 Ref: Down-regulation of aquaporin 5-mediated epithelial-mesenchymal transition and anti-metastatic effect by natural product Cairicoside E in colorectal cancer. PMID: 28833571 Ref: Silibinin attenuates radiation-induced intestinal fibrosis and reverses epithelial-to-mesenchymal transition. PMID: 29050211 |
Ref: Chorionic Gonadotropin-beta Modulates Epithelial-Mesenchymal Transition in Colorectal Carcinoma Metastasis. PMID: 29037859 Ref: Multispectral imaging reveals hyper active TGF-beta signaling in colorectal cancer. PMID: 29219668 Ref: Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis. PMID: 29443735 Ref: NIT1 suppresses tumour proliferation by activating the TGFbeta1-Smad2/3 signalling pathway in colorectal cancer. PMID: 29449642 Ref: Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. PMID: 29453410 Ref: GDF11/BMP11 as a novel tumor marker for liver cancer. PMID: 29545874 Ref: TGFbeta and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells. PMID: 29599290 Ref: Tumor-Associated Macrophages Derived TGF-betaInduced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells through Smad2,3-4/Snail Signaling Pathway. PMID: 29690747 Ref: FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway. PMID: 29844309 Ref: Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations. PMID: 29945573 Ref: Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis. PMID: 29967250 Ref: Transforming Growth Factor-beta1/Smad7 in Intestinal Immunity, Inflammation, and Cancer. PMID: 29973939 Ref: Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing. PMID: 30182733 |