Primary Site >> Colorectal Cancer
Gene >> SLC5A8
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Ref: The therapeutic effect of OK-432-combined adoptive immunotherapy against liver metastases from gastric or colorectal cancers. PMID: 8507544 |
Ref: IL-2-Activated Killer Cells and Native Cytokines in Treatment of Patients with Advanced Cancer. PMID: 12687071 |
Ref: Expression of signal transducing T-cell receptor zeta molecules after adoptive immunotherapy in patients with gastric and colon cancer. PMID: 9766562 |
Ref: SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. PMID: 12829793 |
Ref: Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids. PMID: 14966140 Ref: The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. PMID: 15090606 Ref: Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. PMID: 15113149 Ref: Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer. PMID: 15361710 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: Biological functions of SLC5A8, a candidate tumour suppressor. PMID: 15667316 |
Ref: SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. PMID: 16375929 Ref: Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT. PMID: 16670197 |
Ref: Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. PMID: 18446519 Ref: Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer. PMID: 18661192 Ref: Modulation of intestinal environment by prebiotic germinated barley foodstuff prevents chemo-induced colonic carcinogenesis in rats. PMID: 18813820 |
Ref: Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. PMID: 18789002 Ref: Anti-MTOC-MT antibody is commonly detected by AIT test in colorectal cancer patients. PMID: 19513746 Ref: Measuring the combinatorial expression of solute transporters and metalloproteinases transcripts in colorectal cancer. PMID: 19689820 |
Ref: CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. PMID: 19900445 Ref: Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. PMID: 20160714 Ref: Deletion mapping of chromosome region 12q13-24 in colorectal cancer. PMID: 20633766 Ref: Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. PMID: 20732443 |
Ref: Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate. PMID: 21499304 Ref: [Safety and effectiveness of large dose compound Sophora flavescens Ait injection in the treatment of advanced malignant tumors]. PMID: 21575502 Ref: SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas. PMID: 21687703 |
Ref: Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. PMID: 22517765 Ref: Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells. PMID: 22552910 |
Ref: Butyrate and colorectal cancer: the role of butyrate transport. PMID: 24160296 Ref: Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice. PMID: 24204690 |
Ref: Prognostic Significance of Aberrant Methylation of Solute Carrier Gene Family 5A8 in Lung Adenocarcinoma. PMID: 25827678 Ref: Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. PMID: 25984582 Ref: DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas. PMID: 26203307 |
Ref: The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? PMID: 27346602 Ref: Oxymatrine inhibits epithelial-mesenchymal transition through regulation of NF-kappaB signaling in colorectal cancer cells. PMID: 27430890 Ref: Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications. PMID: 28874966 |
Ref: Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-beta1/Smad signaling pathway. PMID: 27959430 Ref: Effect of butyrate and Lactobacillus GG on a butyrate receptor and transporter during Campylobacter jejuni exposure. PMID: 28333199 Ref: Effective cytotoxic activity of OSW-1 on colon cancer by inducing apoptosis in vitro and in vivo. PMID: 28440433 Ref: Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis. PMID: 29357130 |
Ref: The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications. PMID: 29848266 |