Primary Site >> Colorectal Cancer
Gene >> SLC19A1
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Ref: ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer. PMID: 7577036 Ref: Folate-based thymidylate synthase inhibitors as anticancer drugs. PMID: 8624289 |
Ref: Tomudex (ZD1694): from concept to care, a programme in rational drug discovery. PMID: 8958186 Ref: Thymidylate synthase inhibitors. PMID: 9816165 |
Ref: Folate-based thymidylate synthase inhibitors in cancer chemotherapy. PMID: 9147608 |
Ref: Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates. PMID: 10956384 |
Ref: mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. PMID: 12813132 Ref: Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression. PMID: 12907242 Ref: Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. PMID: 14676127 |
Ref: Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. PMID: 15705887 Ref: Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients. PMID: 16122883 Ref: Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. PMID: 16284371 Ref: Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. PMID: 16365025 |
Ref: The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. PMID: 16505119 |
Ref: Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice. PMID: 16963246 Ref: Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. PMID: 17449906 Ref: Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels. PMID: 18039426 |
Ref: Fecal collection, ambient preservation, and DNA extraction for PCR amplification of bacterial and human markers from human feces. PMID: 18162191 Ref: p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer. PMID: 18418463 Ref: Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. PMID: 18842806 Ref: The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. PMID: 19172696 |
Ref: Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer. PMID: 18926688 |
Ref: Genes involved with folate uptake and distribution and their association with colorectal cancer risk. PMID: 20037791 |
Ref: Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer. PMID: 21438757 Ref: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. PMID: 21537397 |
Ref: Folate-genetics and colorectal neoplasia: what we know and need to know next. PMID: 23401104 Ref: Immunohistochemical analysis of organic anion transporter 2 and reduced folate carrier 1 in colorectal cancer: Significance as a predictor of response to oral uracil/ftorafur plus leucovorin chemotherapy. PMID: 24649225 |
Ref: Polymorphisms of folate metabolism-related genes and survival of patients with colorectal cancer in the Korean population. PMID: 24100087 Ref: Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism. PMID: 24500500 Ref: Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304). PMID: 25041994 |
Ref: DNA methylation and expression of the folate transporter genes in colorectal cancer. PMID: 25697897 Ref: Association between folate metabolism-related polymorphisms and colorectal cancer risk. PMID: 26137281 Ref: Expression of Folate Pathway Genes in Stage III Colorectal Cancer Correlates with Recurrence Status Following Adjuvant Bolus 5-FU-Based Chemotherapy. PMID: 26193446 |
Ref: Simultaneous, But Not Consecutive, Combination With Folinate Salts Potentiates 5-Fluorouracil Antitumor Activity In Vitro and In Vivo. PMID: 28109077 Ref: One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. PMID: 28968444 |
Ref: Hypermethylation of protocadherin gamma subfamily A12 and solute carrier family 19 A 1 promoters contributes to the occurrence and metastasis of colorectal cancer. PMID: 29805555 Ref: Relationship between folate concentration and expression of folate-associated genes in tissue and plasma after intraoperative administration of leucovorin in patients with colorectal cancer. PMID: 30269276 |