Primary Site >> Colorectal Cancer
Gene >> SIRT6
|
|
|
|
|
|---|---|---|---|---|
|
Ref: GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis. PMID: 17131381 |
Ref: FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. PMID: 23603907 Ref: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. PMID: 23770684 Ref: USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation. PMID: 24332849 |
Ref: Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6. PMID: 26657850 |
Ref: SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage. PMID: 27923994 |
Ref: Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma. PMID: 29227545 Ref: Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway. PMID: 29512698 Ref: SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A. PMID: 29552180 Ref: Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling. PMID: 29957460 Ref: Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer. PMID: 30333863 |