Primary Site >> Colorectal Cancer
Gene >> SHMT1
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Ref: Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. PMID: 15122597 |
Ref: [Activity of the National Oncology R&D Consortium in 2004]. PMID: 15902326 Ref: Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. PMID: 16365025 |
Ref: [Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium]. PMID: 17216011 |
Ref: Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients. PMID: 18996879 Ref: Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk. PMID: 19776626 |
Ref: SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer. PMID: 20920350 |
Ref: Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk. PMID: 21406397 Ref: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. PMID: 21537397 |
Ref: Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PMID: 22438825 |
Ref: Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. PMID: 22961839 Ref: A meta-analysis of the C1420T polymorphism in cytosolic serine hydroxymethyltransferase (SHMT1) among Caucasian colorectal cancer populations. PMID: 23322534 Ref: Folate-genetics and colorectal neoplasia: what we know and need to know next. PMID: 23401104 |
Ref: Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity. PMID: 24500934 Ref: Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304). PMID: 25041994 Ref: Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis. PMID: 25194438 |
Ref: Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population. PMID: 25948668 Ref: Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence. PMID: 26673393 |
Ref: One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. PMID: 28968444 Ref: Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. PMID: 29073064 |
Ref: Dietary Uridine Decreases Tumorigenesis in the Apc(Min/+) Model of Intestinal Cancer. PMID: 29955725 |