Primary Site >> Colorectal Cancer
Gene >> SHC1
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Ref: Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells. PMID: 10773880 |
Ref: Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells. PMID: 12748850 |
Ref: Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. PMID: 16241905 Ref: Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. PMID: 16475687 |
Ref: Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase. PMID: 17496330 Ref: p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer. PMID: 17908971 |
Ref: Gab1 but not Grb2 mediates tumor progression in Met overexpressing colorectal cancer cells. PMID: 18192688 Ref: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. PMID: 18253061 |
Ref: Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. PMID: 19138410 |
Ref: Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. PMID: 21961726 |
Ref: Differential expression of senescence and cell death factors in non-small cell lung and colorectal tumors showing telomere attrition. PMID: 22433385 Ref: [P66shc action on resistance of colon carcinoma RKO cells to oxidative stress]. PMID: 22642111 Ref: Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo. PMID: 23259795 |
Ref: Prooxidant properties of p66shc are mediated by mitochondria in human cells. PMID: 24618848 Ref: Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal cancers independent of KRAS mutational status. PMID: 25090459 |
Ref: YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells. PMID: 26269757 Ref: The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway. PMID: 26464652 |
Ref: Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2. PMID: 27475256 |
Ref: Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 29328495 Ref: Inflammatory genes are novel prognostic biomarkers for colorectal cancer. PMID: 29693170 |