Primary Site >> Pancreatic Cancer

Gene >> SERPINE1

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Ref: Peaks in plasma plasminogen activator inhibitor-1 concentration may explain thrombotic events in cases of pancreatic carcinoma.
PMID: 1591681
 Ref: Expression of plasminogen activators and their inhibitors in human pancreatic carcinoma: immunohistochemical study.
PMID: 8237943
 Ref: Transforming growth factor-beta 1 inhibits generation of angiostatin by human pancreatic cancer cells.
PMID: 9706163
Ref: Enhanced expression of urokinase receptor induced through the tissue factor-factor VIIa pathway in human pancreatic cancer.
PMID: 9766679
 Ref: Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation.
PMID: 10092624
Ref: DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression.
PMID: 10340387
Ref: TGF-beta-1 up-regulates cyclin D1 expression in COLO-357 cells, whereas suppression of cyclin D1 levels is associated with down-regulation of the type I TGF-beta receptor.
PMID: 10471535
Ref: Thrombospondin-1 and transforming growth factor beta-1 upregulate plasminogen activator inhibitor type 1 in pancreatic cancer.
PMID: 10482694
Ref: The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer.
PMID: 10498890
Ref: Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer.
PMID: 10547197
 Ref: FGF-2 isoforms of 18 and 22.5 kDa differentially modulate t-PA and PAI-1 expressions on the pancreatic carcinoma cells AR4-2J: consequences on cell spreading and invasion.
PMID: 10699930
Ref: Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-beta1 and MMPs.
PMID: 11448066
 Ref: TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.
PMID: 12173049
Ref: Induction and expression of betaig-h3 in pancreatic cancer cells.
PMID: 12379307
Ref: Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis.
PMID: 12467210
 Ref: Glypican-1 antisense transfection modulates TGF-beta-dependent signaling in Colo-357 pancreatic cancer cells.
PMID: 15249209
Ref: Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanisms.
PMID: 15479693
 Ref: Plasminogen activator inhibitor-1 (PAI-1) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis.
PMID: 16273237
 Ref: Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system.
PMID: 16547153
 Ref: High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma.
PMID: 17219285
Ref: Gene expression profiling of liver metastases and tumour invasion in pancreatic cancer using an orthotopic SCID mouse model.
PMID: 17940512
Ref: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition.
PMID: 17997817
Ref: Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment.
PMID: 18229422
 Ref: Significant down-regulation of the plasminogen activator inhibitor 1 mRNA in pancreatic cancer.
PMID: 18376309
 Ref: Role of Ras signaling in the induction of snail by transforming growth factor-beta.
PMID: 19010789
 Ref: Early phase TGFbeta receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses.
PMID: 21187158
 Ref: DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA.
PMID: 22223849
 Ref: Prognostic and predictive blood-based biomarkers in patients with advanced pancreatic cancer: results from CALGB80303 (Alliance).
PMID: 24097873
 Ref: Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer.
PMID: 24248418
Ref: VEGF and Id-1 in pancreatic adenocarcinoma: prognostic significance and impact on angiogenesis.
PMID: 24480377
 Ref: Pancreatic cancer and thromboembolic disease, 150 years after Trousseau.
PMID: 26605280
 Ref: Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression.
PMID: 27216198
 Ref: A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women.
PMID: 29573228
Ref: Downregulation of TRAIL-Receptor 1 Increases TGFbeta Type II Receptor Expression and TGFbeta Signalling Via MicroRNA-370-3p in Pancreatic Cancer Cells.
PMID: 30366420