Primary Site >> Liver Cancer
Gene >> RUNX3
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Ref: Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma. PMID: 14760761 Ref: Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. PMID: 14968123 Ref: [Analysis of methylation and loss of heterozygosity of RUNX3 gene in hepatocellular carcinoma and its clinical significance]. PMID: 15099475 Ref: [Improvement and application of methylation-specific polymerase chain reaction]. PMID: 15522190 |
Ref: Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma. PMID: 15780064 Ref: Hypermethylation of the RUNX3 gene in hepatocellular carcinoma. PMID: 16155404 |
Ref: Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of hepatocarcinogenesis. PMID: 17094378 |
Ref: Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. PMID: 17914577 Ref: Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma. PMID: 17968429 |
Ref: Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. PMID: 18161048 Ref: RUNX3 inhibits growth of HCC cells and HCC xenografts in mice in combination with adriamycin. PMID: 18259121 |
Ref: Methylation of multiple genes as molecular markers for diagnosis of a small, well-differentiated hepatocellular carcinoma. PMID: 19384946 |
Ref: RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells. PMID: 19800882 |
Ref: Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis. PMID: 21205319 Ref: Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma. PMID: 21328447 Ref: Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice. PMID: 21374661 Ref: Quantitative methylation analysis of multiple genes using methylation-sensitive restriction enzyme-based quantitative PCR for the detection of hepatocellular carcinoma. PMID: 21600201 Ref: Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling. PMID: 21637926 Ref: Loss of runt-related transcription factor 3 expression associated with human hepatocellular carcinoma progression and prognosis. PMID: 22296371 Ref: [The associated research on the expression of RUNX3 mRNA and protein in hepatic cell carcinoma as well as the relationship with clinical pathological parameters]. PMID: 22734230 |
Ref: Nicotinamide inhibits the early stage of carcinogen-induced hepatocarcinogenesis in mice and suppresses human hepatocellular carcinoma cell growth. PMID: 21503886 Ref: Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. PMID: 22407776 Ref: Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma. PMID: 22488108 Ref: Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell. PMID: 22846564 |
Ref: Clinicopathological significance of RUNX3 gene hypermethylation in hepatocellular carcinoma. PMID: 25037468 Ref: Relationship between RUNX3 methylation and hepatocellular carcinoma in Asian populations: a systematic review. PMID: 25061743 |
Ref: RUNX3 Promoter Methylation Is Associated with Hepatocellular Carcinoma Risk: A Meta-Analysis. PMID: 25664646 Ref: Increased Oxidative Stress and RUNX3 Hypermethylation in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma (HCC) and Induction of RUNX3 Hypermethylation by Reactive Oxygen Species in HCC Cells. PMID: 26225676 |
Ref: Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma. PMID: 26985715 Ref: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations. PMID: 27009864 Ref: RUNX3 promoter methylation correlation with pathogenesis of hepatocellular carcinoma in Asians. PMID: 27420934 Ref: Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma. PMID: 27646854 Ref: MicroRNA-20a-5p targets RUNX3 to regulate proliferation and migration of human hepatocellular cancer cells. PMID: 27748919 Ref: Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma. PMID: 27835605 |
Ref: Epigenetic mechanisms regulating the development of hepatocellular carcinoma and their promise for therapeutics. PMID: 27271356 Ref: [Corrigendum] Loss of Runtrelated transcription factor 3 induces resistance to 5fluorouracil and cisplatin in hepatocellular carcinoma. PMID: 28184917 Ref: Aberrant methylation of RUNX3 is present in Aflatoxin B1-induced transformation of the L02R cell line. PMID: 28458013 Ref: RUNX3 regulates hepatocellular carcinoma cell metastasis via targeting miR-186/E-cadherin/EMT pathway. PMID: 28977878 Ref: Methylation analysis of p16, SLIT2, SCARA5, and Runx3 genes in hepatocellular carcinoma. PMID: 29019900 |
Ref: MiR-544 promotes immune escape through downregulation of NCR1/NKp46 via targeting RUNX3 in liver cancer. PMID: 29636640 |