Primary Site >> Stomach Cancer
Gene >> RUNX3
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Ref: Causal relationship between the loss of RUNX3 expression and gastric cancer. PMID: 11955451 Ref: RUNX: a trilogy of cancer genes. PMID: 12086855 Ref: Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. PMID: 12447699 |
Ref: RUNX transcription factors as key targets of TGF-beta superfamily signaling. PMID: 12573434 Ref: Comment on Levanon et al., "Runx3 knockouts and stomach cancer", in EMBO reports (June 2003). PMID: 12776167 Ref: Runx3 knockouts and stomach cancer. PMID: 12776174 Ref: Runx transcription factors and the developmental balance between cell proliferation and differentiation. PMID: 12788047 Ref: Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia. PMID: 12824905 Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 Ref: Therapeutic strategies in gastric cancer. PMID: 14645406 |
Ref: Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia. PMID: 14702190 Ref: Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. PMID: 14743205 Ref: Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. PMID: 14968123 Ref: RUNX3 expression in primary and metastatic pancreatic cancer. PMID: 14990603 Ref: Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma. PMID: 15051926 Ref: Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. PMID: 15138260 Ref: Oncogenic potential of the RUNX gene family: 'overview'. PMID: 15156173 Ref: Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins. PMID: 15156178 Ref: Growth regulation of gastric epithelial cells by Runx3. PMID: 15156189 Ref: Tumor suppressor activity of RUNX3. PMID: 15156190 Ref: Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients. PMID: 15173255 Ref: Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. PMID: 15273736 Ref: Early-onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age. PMID: 15307140 Ref: Runx3-/- gastric epithelial cells differentiate into intestinal type cells. PMID: 15358215 Ref: Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma. PMID: 15379759 Ref: [Improvement and application of methylation-specific polymerase chain reaction]. PMID: 15522190 |
Ref: Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. PMID: 15386419 Ref: Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography. PMID: 15685235 Ref: Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. PMID: 15735748 Ref: Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1. PMID: 15756676 Ref: Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. PMID: 15930301 Ref: RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer. PMID: 16080503 Ref: Exclusion of RUNX3 as a tumour-suppressor gene in early-onset gastric carcinomas. PMID: 16091737 Ref: RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. PMID: 16135801 Ref: RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. PMID: 16140942 Ref: Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. PMID: 16142337 Ref: Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers. PMID: 16166423 Ref: RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors. PMID: 16230397 |
Ref: Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2. PMID: 16110492 Ref: Spreading of methylation within RUNX3 CpG island in gastric cancer. PMID: 16367921 Ref: RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. PMID: 16373335 Ref: Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. PMID: 16482617 Ref: Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms. PMID: 16586533 Ref: How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions. PMID: 16627973 Ref: The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. PMID: 16738314 Ref: Runx3 expression during mouse tongue and palate development. PMID: 16761282 Ref: Lack of RUNX3 regulation in human gastric cancer. PMID: 16917803 Ref: Gastric-and-intestinal mixed-type intestinal metaplasia: aberrant expression of transcription factors and stem cell intestinalization. PMID: 16952033 Ref: Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia. PMID: 16952303 Ref: Expression status of RUNX1/AML1 in normal gastric epithelium and its mutational analysis in microdissected gastric cancer cells. PMID: 16964375 Ref: Quantitative assessment of RUNX3 methylation in neoplastic and non-neoplastic gastric epithelia using a DNA microarray. PMID: 16984612 Ref: RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. PMID: 17085650 Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 Ref: Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of hepatocarcinogenesis. PMID: 17094378 |
Ref: Runt-related transcription factor 3 expression in human oral squamous cell carcinomas; implication for tumor progression and prognosis. PMID: 16798064 Ref: Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment. PMID: 17276407 Ref: [Reappraisal of the impacts of human Runt-related transcription factor gene 3 expression on differentiation and prognosis of gastric cancer]. PMID: 17380460 Ref: Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosis. PMID: 17384682 Ref: GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. PMID: 17471240 Ref: Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. PMID: 17568183 Ref: Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy. PMID: 17571247 Ref: Aberrant methylation within RUNX3 CpG island associated with the nuclear and mitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. PMID: 17591800 Ref: Runx3 interacts with DNA repair protein Ku70. PMID: 17662272 Ref: Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patients. PMID: 18008030 |
Ref: Apoptotic pathway induced by transduction of RUNX3 in the human gastric carcinoma cell line MKN-1. PMID: 17956589 Ref: RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. PMID: 18037406 Ref: Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer. PMID: 18097595 Ref: Decreased expression of RUNX3 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma. PMID: 18288406 Ref: Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration. PMID: 18400571 Ref: Expression of RUNX3 in salivary adenoid cystic carcinoma: implications for tumor progression and prognosis. PMID: 18410404 Ref: Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation. PMID: 18430739 Ref: Investigation of transcriptional gene silencing and mechanism induced by shRNAs targeted to RUNX3 in vitro. PMID: 18494051 Ref: Clinicopathological and prognostic significance of mucin phenotype in gastric cancer. PMID: 18521835 Ref: E1A physically interacts with RUNX3 and inhibits its transactivation activity. PMID: 18570183 Ref: Expression of RUNX3 gene, methylation status and clinicopathological significance in breast cancer and breast cancer cell lines. PMID: 18580070 Ref: [Promoter methylation and expression of Runx3 gene in gastric cancer]. PMID: 18636364 Ref: RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. PMID: 18772112 Ref: Reprimo as a potential biomarker for early detection in gastric cancer. PMID: 18829507 Ref: [Relationship between Runx3 gene expression and its DNA methylation in gastric cancer]. PMID: 18953836 Ref: Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma. PMID: 20485621 |
Ref: Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. PMID: 18850007 Ref: RUNX3 expression correlates with chief cell differentiation in human gastric cancers. PMID: 19012242 Ref: Molecular basis of therapeutic approaches to gastric cancer. PMID: 19196394 Ref: Loss of RUNX3 expression correlates with differentiation, nodal metastasis, and poor prognosis of gastric cancer. PMID: 19290488 Ref: Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3. PMID: 19350572 Ref: Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma. PMID: 19360301 Ref: Genetic variants in the Runt-related transcription factor 3 gene contribute to gastric cancer risk in a Chinese population. PMID: 19552756 Ref: Quantitative analysis of tumor-derived methylated RUNX3 sequences in the serum of gastric cancer patients. PMID: 19596937 Ref: Molecular pathology of RUNX3 in human carcinogenesis. PMID: 19682550 Ref: Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions. PMID: 19695681 Ref: [Relationship between RUNX3 expression and precancerous gastric lesions in high-risk population]. PMID: 19727221 Ref: Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese. PMID: 19728008 |
Ref: Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. PMID: 19706291 Ref: Aberrant gene methylation in the lymph nodes provides a possible marker for diagnosing micrometastasis in gastric cancer. PMID: 19957042 Ref: MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. PMID: 20176475 Ref: Molecular analysis of gastric differentiated-type intramucosal and submucosal cancers. PMID: 20178104 Ref: RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53. PMID: 20353948 Ref: BCL2L10 is frequently silenced by promoter hypermethylation in gastric cancer. PMID: 20428828 Ref: Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer. PMID: 20492341 Ref: Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction. PMID: 20599712 Ref: Risk factors in malignant transformation of gastric epithelial neoplasia categorized by the revised Vienna classification: endoscopic, pathological, and immunophenotypic features. PMID: 20602200 Ref: The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer. PMID: 20631058 Ref: Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation. PMID: 20676134 Ref: RUNX3 promoter methylation in colorectal cancer: its relationship with microsatellite instability and its suitability as a novel serum tumor marker. PMID: 20682997 Ref: Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. PMID: 21160888 Ref: The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma. PMID: 21203466 Ref: Promoter methylation of p16, Runx3, DAPK and CHFR genes is frequent in gastric carcinoma. PMID: 21302620 |
Ref: Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer. PMID: 20300977 Ref: Runx3 suppresses gastric cancer metastasis through inactivation of MMP9 by upregulation of TIMP-1. PMID: 21128246 Ref: RUNX3 methylation and expression associated with advanced precancerous gastric lesions in a Chinese population. PMID: 21135153 Ref: Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis. PMID: 21205319 Ref: New insights into the inactivation of gastric tumor suppressor RUNX3: the role of H. pylori infection. PMID: 21268057 Ref: Loss of Runx3 is a key event in inducing precancerous state of the stomach. PMID: 21277301 Ref: Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma. PMID: 21328447 Ref: Increased genetic susceptibility to intestinal-type gastric cancer is associated with increased activity of the RUNX3 distal promoter. PMID: 21523770 Ref: Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. PMID: 21786422 Ref: Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis. PMID: 21867527 Ref: Gastric cancer: basic aspects. PMID: 21896084 Ref: Molecular pathology of gastric carcinoma. PMID: 22104201 Ref: Global DNA methylation and tumor suppressor gene promoter methylation and gastric cancer risk in an Omani Arab population. PMID: 22126203 Ref: Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients. PMID: 22234069 Ref: Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients. PMID: 22848301 |
Ref: Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm. PMID: 21567391 Ref: Identification of RUNX3 as a component of the MST/Hpo signaling pathway. PMID: 21678419 Ref: RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. PMID: 22231444 Ref: Helicobacter pylori CagA inhibits the expression of Runx3 via Src/MEK/ERK and p38 MAPK pathways in gastric epithelial cell. PMID: 22266963 Ref: Stepwise cumulation of RUNX3 methylation mediated by Helicobacter pylori infection contributes to gastric carcinoma progression. PMID: 22576578 Ref: 5-Aza-2'-deoxycytidine induces cytotoxicity in BGC-823 cells via DNA methyltransferase 1 and 3a independent of p53 status. PMID: 22664909 Ref: [Correlation of CpG methylation status of Runx3 with pathogenesis of gastric carcinoma]. PMID: 22883670 Ref: Loss of heterozygosity at chromosomes 1p35-pter, 4q, and 18q and protein expression differences between adenocarcinomas of the distal stomach and gastric cardia. PMID: 22901464 Ref: Promoter methylation of tumor-related genes in gastric carcinogenesis. PMID: 22936446 Ref: Downregulation of Hlx closely related to the decreased expressions of T-bet and Runx3 in patients with gastric cancer may be associated with a pathological event leading to the imbalance of Th1/Th2. PMID: 23243425 |
Ref: Role of DNA methylation in the development of Epstein-Barr virus-associated gastric carcinoma. PMID: 23073987 Ref: Antitumor activity of cell-permeable RUNX3 protein in gastric cancer cells. PMID: 23230322 Ref: Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer. PMID: 23338485 Ref: MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer. PMID: 23549984 Ref: Evaluation of the relationship between dietary factors, CagA-positive Helicobacter pylori infection, and RUNX3 promoter hypermethylation in gastric cancer tissue. PMID: 23555166 Ref: Loss of RUNX3 increases osteopontin expression and promotes cell migration in gastric cancer. PMID: 23774402 Ref: MicroRNA-106a induces multidrug resistance in gastric cancer by targeting RUNX3. PMID: 23932924 Ref: Runt-related transcription factor 3: single nucleotide polymorphism rs760805, gene expression, and methylation status in Helicobacter pylori -infected patients for determination of gastric cancer risk. PMID: 23959374 Ref: Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis. PMID: 23982143 Ref: An inverse relationship between the expression of the gastric tumor suppressor RUNX3 and infection with Helicobacter pylori in gastric epithelial dysplasia. PMID: 24312710 Ref: [Allelic imbalance of loci 17p13.1 (TP53), 1p36.1 (RUNX3), 16p22 (CDH1) and microsatellite instability in gastric cancer]. PMID: 25509356 |
Ref: RUNX3 inhibits hypoxia-inducible factor-1alpha protein stability by interacting with prolyl hydroxylases in gastric cancer cells. PMID: 23542169 Ref: Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells. PMID: 24447505 Ref: RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric cancer cells. PMID: 24447545 Ref: RUNX3 inhibits survivin expression and induces cell apoptosis in gastric cancer. PMID: 24636883 Ref: Slow overmethylation of housekeeping genes in the body mucosa is associated with the risk for gastric cancer. PMID: 24654229 Ref: Helicobacter pylori and gastric cancer. PMID: 24732191 Ref: MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain. PMID: 24763054 Ref: [Relationship between promoter methylation of Syk and Runx3 genes and postoperative recurrence and metastasis in gastric carcinoma]. PMID: 25030588 Ref: Downregulation of Runx3 is closely related to the decreased Th1-associated factors in patients with gastric carcinoma. PMID: 25270738 Ref: A systematic review and meta-analysis of runt-related transcription factor 3 gene promoter hypermethylation and risk of gastric cancer. PMID: 25693942 |
Ref: Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer. PMID: 25088199 Ref: Runx3 at the interface of immunity, inflammation and cancer. PMID: 25641675 Ref: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection. PMID: 25884934 Ref: A study of RUNX3, E-cadherin and beta-catenin in CagA-positive Helicobacter pylori associated chronic gastritis in Saudi patients. PMID: 25967717 Ref: miR-130a acts as a potential diagnostic biomarker and promotes gastric cancer migration, invasion and proliferation by targeting RUNX3. PMID: 26134263 Ref: UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation. PMID: 26147747 Ref: RUNX3 Methylation, Loss of RUNX3 Expression and Clinicopathologic Findings according to Helicobacter pylori CagA in Gastric Carcinoma. PMID: 26289240 Ref: Targeting of RUNX3 by miR-130a and miR-495 cooperatively increases cell proliferation and tumor angiogenesis in gastric cancer cells. PMID: 26375442 Ref: Wnt/beta-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis. PMID: 26417932 |
Ref: RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer. PMID: 26364597 Ref: miRNA-532-5p functions as an oncogenic microRNA in human gastric cancer by directly targeting RUNX3. PMID: 26515139 Ref: Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma. PMID: 26985715 Ref: RUNX3-mediated up-regulation of miR-29b suppresses the proliferation and migration of gastric cancer cells by targeting KDM2A. PMID: 27497248 Ref: Epigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment. PMID: 27566570 Ref: Site-specific Hypermethylation of RUNX3 Predicts Poor Prognosis in Gastric Cancer. PMID: 27664488 Ref: Generation of RUNX3 knockout pigs using CRISPR/Cas9-mediated gene targeting. PMID: 27696566 Ref: The association between runt-related transcription factor 3 gene promoter methylation and gastric cancer: A meta-analysis. PMID: 27721253 |
Ref: RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3. PMID: 27425596 Ref: Decitabine inhibits tumor cell proliferation and up-regulates e-cadherin expression in Epstein-Barr virus-associated gastric cancer. PMID: 27430892 Ref: Runx3 in Immunity, Inflammation and Cancer. PMID: 28299669 Ref: Roles of RUNX in Hippo Pathway Signaling. PMID: 28299672 Ref: Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection. PMID: 28512631 Ref: Combined Detection of Plasma ZIC1, HOXD10 and RUNX3 Methylation is a Promising Strategy for Early Detection of Gastric Cancer and Precancerous Lesions. PMID: 28529617 Ref: The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer. PMID: 28757548 Ref: The Relationship between RUNX3 Expression, Nursing Strategies and Nutritional Status in Elderly Patients with Advanced Gastric Cancer. PMID: 28828318 Ref: RUNX3 inhibits the proliferation and metastasis of gastric cancer through regulating miR-182/HOXA9. PMID: 29054094 Ref: Promoter methylation of tumor-related genes as a potential biomarker using blood samples for gastric cancer detection. PMID: 29100425 |
Ref: HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells. PMID: 29417297 Ref: Loss of expression rather than cytoplasmic mislocalization of RUNX3 predicts worse outcome in non-small cell lung cancer. PMID: 29545901 Ref: Clinicopathological and prognostic significance of the RUNX3 expression in gastric cancer: a systematic review and meta-analysis. PMID: 29578091 Ref: LncRNA MT1JP Suppresses Gastric Cancer Cell Proliferation and Migration Through MT1JP/MiR-214-3p/RUNX3 Axis. PMID: 29742512 Ref: Gastric Mucosal Atrophy Impedes Housekeeping Gene Methylation in Gastric Cancer Patients. PMID: 29747491 Ref: Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p. PMID: 30061181 |