Primary Site >> Colorectal Cancer
Gene >> RSPO1
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|
|
Ref: LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PMID: 22615920 Ref: Recurrent R-spondin fusions in colon cancer. PMID: 22895193 |
Ref: Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. PMID: 23142137 Ref: LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/beta-Catenin Signaling. PMID: 23596566 |
Ref: Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells. PMID: 24677446 Ref: RSPO fusion transcripts in colorectal cancer in Japanese population. PMID: 24847761 |
Ref: Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. PMID: 25531322 Ref: Prospective derivation of a living organoid biobank of colorectal cancer patients. PMID: 25957691 |
Ref: Wnt addiction of genetically defined cancers reversed by PORCN inhibition. PMID: 26257057 Ref: Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth. PMID: 27401612 Ref: Murine Colonic Organoid Culture System and Downstream Assay Applications. PMID: 27539462 |
Ref: RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis. PMID: 27511199 Ref: [Expression of regulatory factor R-spondin family in Wnt signaling pathway in colorectal cancer and its clinical significance]. PMID: 28626093 Ref: LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. PMID: 28739799 Ref: R-Spondin1/LGR5 Activates TGFbeta Signaling and Suppresses Colon Cancer Metastasis. PMID: 28939678 Ref: RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations. PMID: 29127379 |
Ref: Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells. PMID: 29316729 |