Primary Site >> Colorectal Cancer
Gene >> RPS6KB1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. PMID: 10993886 |
Ref: Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture. PMID: 12000755 |
Ref: Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells. PMID: 15304500 |
Ref: Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells. PMID: 16328013 |
Ref: Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer. PMID: 17175097 Ref: Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis. PMID: 17265080 |
Ref: Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy. PMID: 18381446 |
Ref: Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. PMID: 21035469 Ref: Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer. PMID: 21429662 Ref: Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. PMID: 21673091 Ref: Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment. PMID: 21999454 Ref: Deoxyribose protects against rapamycin-induced cytotoxicity in colorectal cancer cells in vitro. PMID: 22132975 |
Ref: Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. PMID: 22406476 |
Ref: Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells. PMID: 23188704 Ref: Genotype directed therapy in murine mismatch repair deficient tumors. PMID: 23935891 |
Ref: Chronic insulin exposure does not cause insulin resistance but is associated with chemo-resistance in colon cancer cells. PMID: 24068609 Ref: Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation. PMID: 24363449 Ref: Alpha-2-glycoprotein 1(AZGP1) regulates biological behaviors of LoVo cells by down-regulating mTOR signaling pathway and endogenous fatty acid synthesis. PMID: 24918753 Ref: Influence of CHIEF pathway genes on gene expression: a pathway approach to functionality. PMID: 24959314 |
Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: Differential regulation of autophagy and cell viability by ceramide species. PMID: 25803131 |
Ref: The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells. PMID: 27167250 Ref: mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity. PMID: 27565731 |
Ref: Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses. PMID: 27663511 Ref: Preclinical study of cinobufagin as a promising anti-colorectal cancer agent. PMID: 27894091 Ref: Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival. PMID: 28138309 Ref: Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells. PMID: 28184936 Ref: Identification of RING-box 2 as a potential target for combating colorectal cancer growth and metastasis. PMID: 28670488 Ref: Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients. PMID: 28692053 Ref: Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway. PMID: 28972559 Ref: Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death. PMID: 29179457 |
Ref: AZD8055 Exerts Antitumor Effects on Colon Cancer Cells by Inhibiting mTOR and Cell-cycle Progression. PMID: 29491070 Ref: Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. PMID: 30087121 Ref: The influence of aberrant expression of GLI1/p-S6K on colorectal cancer. PMID: 30143258 Ref: Neratinib augments the lethality of [regorafenib + sildenafil]. PMID: 30203445 Ref: Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1. PMID: 30342037 |