Primary Site >> Colorectal Cancer
Gene >> RNF43
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Ref: A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. PMID: 15492824 Ref: Ring finger protein 43 as a new target for cancer immunotherapy. PMID: 15623641 |
Ref: A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95. PMID: 18313049 Ref: Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins. PMID: 18655028 Ref: [Phase I study of combination therapy with peptide vaccine and anti-cancer drug for colorectal cancer]. PMID: 19106592 |
Ref: RNF43 interacts with NEDL1 and regulates p53-mediated transcription. PMID: 21108931 |
Ref: Significant clinical response of advanced colon cancer to peptide vaccine therapy: a case report. PMID: 22763829 Ref: Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. PMID: 22895187 Ref: [Clinical study of Peptide-cocktail vaccination with tegafur-uracil/leucovorin for advanced colorectal cancer]. PMID: 23267878 |
Ref: Reversing effect of ring finger protein 43 inhibition on malignant phenotypes of human hepatocellular carcinoma. PMID: 23136185 Ref: Oncogenic Wnt/beta-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research. PMID: 23155044 Ref: Phase I clinical trial of a peptide vaccine combined with tegafur-uracil plus leucovorin for treatment of advanced or recurrent colorectal cancer. PMID: 23314271 Ref: [Treatment outcome of peptide vaccination for advanced colorectal cancer]. PMID: 24393856 |
Ref: Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene. PMID: 24466159 Ref: The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. PMID: 24532711 Ref: Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. PMID: 24609463 Ref: A phase I study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome. PMID: 24612787 Ref: [Clinical trial of a seven-peptide vaccine and tegafur-uracil/leucovorin as combination therapy for advanced colorectal cancer]. PMID: 25335716 |
Ref: Downregulation of ring-finger protein 43 in glioma associates with poor prognosis. PMID: 25755738 Ref: Prospective derivation of a living organoid biobank of colorectal cancer patients. PMID: 25957691 Ref: Frequent frameshift mutations in 2 mononucleotide repeats of RNF43 gene and its regional heterogeneity in gastric and colorectal cancers. PMID: 26297255 Ref: The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated beta-catenin by sequestering TCF4 to the nuclear membrane. PMID: 26350900 Ref: Clinicopathological significance and prognostic value of Wilms' tumor gene expression in colorectal cancer. PMID: 26406403 |
Ref: Brg-1 targeting of novel miR550a-5p/RNF43/Wnt signaling axis regulates colorectal cancer metastasis. PMID: 25961913 Ref: RNF43 Is an Early and Specific Mutated Gene in the Serrated Pathway, With Increased Frequency in Traditional Serrated Adenoma and Its Associated Malignancy. PMID: 27305845 Ref: Spectrum of Gene Mutations in Colorectal Cancer: Implications for Treatment. PMID: 27341591 Ref: Transcriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases. PMID: 27461012 Ref: RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis. PMID: 27661107 |
Ref: RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation. PMID: 27329244 Ref: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. PMID: 27869803 Ref: Phase 1 study of OCV-C02, a peptide vaccine consisting of two peptide epitopes for refractory metastatic colorectal cancer. PMID: 28266765 Ref: CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies. PMID: 28344746 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Molecular genetics and targeted therapy of WNT-related human diseases (Review). PMID: 28731148 Ref: RT-qPCR analysis of the tumor antigens TOMM34 and RNF43 in samples extracted from paraffin-embedded specimens of colorectal cancer. PMID: 28789449 Ref: Brg-1 targeting of novel miR550a-5p/RNF43/Wnt signaling axis regulates colorectal cancer metastasis. PMID: 28846106 Ref: DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. PMID: 29021137 Ref: RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations. PMID: 29127379 Ref: Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS). PMID: 29213343 Ref: ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer. PMID: 29370427 |
Ref: RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers. PMID: 28573495 Ref: Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer. PMID: 29316426 Ref: Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in the Wnt signaling. PMID: 29416670 Ref: IgG response to MHC class I epitope peptides is a quantitative predictive biomarker in the early course of treatment of colorectal cancer using therapeutic peptides. PMID: 29498403 Ref: Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression. PMID: 29756208 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas. PMID: 29945994 Ref: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells. PMID: 30017821 Ref: Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells. PMID: 30380024 |