Primary Site >> Pancreatic Cancer
Gene >> RHOA
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Ref: Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. PMID: 9459160 Ref: p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA. PMID: 9819384 |
Ref: Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. PMID: 11406567 |
Ref: 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. PMID: 11832446 |
Ref: Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK. PMID: 12902401 Ref: Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor. PMID: 14598891 |
Ref: Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells. PMID: 15289335 |
Ref: Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. PMID: 16052215 |
Ref: Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38. PMID: 16257181 Ref: Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis. PMID: 16776779 |
Ref: STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review). PMID: 17203201 Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. PMID: 17390031 |
Ref: Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis. PMID: 18495213 |
Ref: LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites. PMID: 19129242 Ref: In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. PMID: 19417142 Ref: Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. PMID: 19424602 Ref: Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity. PMID: 19642867 Ref: TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation. PMID: 19773448 |
Ref: RHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones. PMID: 20236512 Ref: The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model. PMID: 21084261 |
Ref: Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. PMID: 21266354 Ref: Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells. PMID: 21722395 Ref: BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation. PMID: 21833473 Ref: Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I. PMID: 22028818 Ref: Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation. PMID: 22074495 |
Ref: Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice. PMID: 22287227 Ref: NOP14 promotes proliferation and metastasis of pancreatic cancer cells. PMID: 22425761 Ref: miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway. PMID: 23070684 |
Ref: Balanced Tiam1-rac1 and RhoA drives proliferation and invasion of pancreatic cancer cells. PMID: 23322732 Ref: Saponins extracted from by-product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway. PMID: 23450726 Ref: In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells. PMID: 23607551 Ref: RhoC interacts with integrin alpha5beta1 and enhances its trafficking in migrating pancreatic carcinoma cells. PMID: 24312560 |
Ref: Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K-AKT and RhoA pathways after carbon ion irradiation. PMID: 25019574 |
Ref: Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. PMID: 24115212 Ref: GRP78 promotes the invasion of pancreatic cancer cells by FAK and JNK. PMID: 25218495 Ref: Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity. PMID: 25529011 Ref: Identification of biomarkers for the prognosis of pancreatic ductal adenocarcinoma with miRNA microarray data. PMID: 25791160 Ref: The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion. PMID: 25886367 Ref: Carbon-Ion Irradiation Suppresses Migration and Invasiveness of Human Pancreatic Carcinoma Cells MIAPaCa-2 via Rac1 and RhoA Degradation. PMID: 26279033 Ref: Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways. PMID: 26512205 Ref: Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer. PMID: 26530532 |
Ref: Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells. PMID: 26707801 Ref: Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1. PMID: 26747707 Ref: ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells. PMID: 27145964 Ref: Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study. PMID: 27181081 Ref: Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells. PMID: 27503856 Ref: ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells. PMID: 27824338 Ref: Analysis of transcription profile to reveal altered signaling pathways following the overexpression of human desumoylating isopeptidase 2 in pancreatic cancer cells. PMID: 28105175 |
Ref: An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer. PMID: 27835861 Ref: Expression of orphan GPR56 correlates with tumor progression in human epithelial ovarian cancer. PMID: 27881002 Ref: Discovery and characterization of small molecule Rac1 inhibitors. PMID: 28410221 Ref: Crizotinib, a MET inhibitor, prevents peritoneal dissemination in pancreatic cancer. PMID: 28498406 Ref: ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca(2+)/RhoA pathway. PMID: 28518134 Ref: A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts. PMID: 28978480 Ref: Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in pancreatic cancer. PMID: 29121972 |
Ref: Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha. PMID: 29048560 Ref: Transforming growth factor-beta modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion. PMID: 29477748 Ref: Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids. PMID: 29543440 Ref: Gastrin stimulates pancreatic cancer cell directional migration by activating the Galpha12/13-RhoA-ROCK signaling pathway. PMID: 29717112 Ref: Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a beta1-integrin-FAK-YAP1/TAZ signaling pathway. PMID: 29872721 Ref: Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis. PMID: 30064461 |