Primary Site >> Stomach Cancer
Gene >> RHOA
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Ref: Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin. PMID: 12105855 |
Ref: Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. PMID: 12808021 Ref: E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells. PMID: 14500541 |
Ref: Expression of seven main Rho family members in gastric carcinoma. PMID: 14975755 Ref: Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis. PMID: 14996729 Ref: [The expression and possible function of RhoA in human gastric cancer cell lines]. PMID: 15059348 Ref: Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. PMID: 15109306 Ref: Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. PMID: 15448013 |
Ref: Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities. PMID: 15961394 Ref: The cross talk between protein kinase A- and RhoA-mediated signaling in cancer cells. PMID: 16246900 Ref: WNT/PCP signaling pathway and human cancer (review). PMID: 16273260 Ref: Characterization of RhoA-mediated chemoresistance in gastric cancer cells. PMID: 19956523 |
Ref: Integrin signaling and cell spreading mediated by phorbol 12-myristate 13-acetate treatment. PMID: 16598791 |
Ref: Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. PMID: 17273778 Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. PMID: 17304514 Ref: Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. PMID: 17390031 Ref: EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells. PMID: 17510211 Ref: Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. PMID: 17568183 Ref: RhoA and RhoC -siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway. PMID: 17659701 |
Ref: Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis. PMID: 18231637 Ref: Lysophosphatidic acid promotes cell invasion by up-regulating the urokinase-type plasminogen activator receptor in human gastric cancer cells. PMID: 18247343 Ref: Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901. PMID: 18300342 Ref: NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer. PMID: 18827818 |
Ref: RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors. PMID: 19372585 Ref: Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. PMID: 19424602 |
Ref: Suppression of gastric cancer dissemination by ephrin-B1-derived peptide. PMID: 19804421 Ref: Grp78 promotes the invasion of hepatocellular carcinoma. PMID: 20082722 Ref: Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells. PMID: 20145621 Ref: Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals. PMID: 20600540 Ref: Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways. PMID: 20651362 |
Ref: A distinct role of RhoB in gastric cancer suppression. PMID: 20473933 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways. PMID: 20498032 Ref: A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer. PMID: 21284875 Ref: Fibronectin increases RhoA activity through inhibition of PKA in the human gastric cancer cell line SGC-7901. PMID: 21461565 Ref: [Expression and significance of RhoA and NF-KappaB in human gastric carcinoma]. PMID: 21575498 Ref: RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility. PMID: 21667311 Ref: Factors influencing RhoA protein distribution in the nucleus. PMID: 21850373 Ref: [The effect of RhoA and proteasome inhibitor MG132 on angiogenesis in tumors]. PMID: 21866623 |
Ref: Lymphatic endothelial cell-secreted CXCL1 stimulates lymphangiogenesis and metastasis of gastric cancer. PMID: 21387301 Ref: Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells. PMID: 22337890 Ref: Inhibition of RhoA/ROCK signaling pathway promotes the apoptosis of gastric cancer cells. PMID: 22584506 |
Ref: PI3K/Akt-dependent phosphorylation of GSK3beta and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration. PMID: 23123500 Ref: The activation of proteinase-activated receptor-1 (PAR1) promotes gastric cancer cell alteration of cellular morphology related to cell motility and invasion. PMID: 23242308 Ref: STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells. PMID: 23333463 Ref: Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells. PMID: 23799130 Ref: Nuclear translocation of small G protein RhoA via active transportation in gastric cancer cells. PMID: 23900609 Ref: Reduced expression of Rho GDP dissociation inhibitor 2 mRNA is associated with lymph node metastasis in gastric carcinoma. PMID: 24137348 |
Ref: Type II cGMPdependent protein kinase inhibits RhoA activation in gastric cancer cells. PMID: 24549567 Ref: Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. PMID: 24816253 Ref: Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. PMID: 24816255 Ref: Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway. PMID: 24885567 Ref: RhoA mutations identified in diffuse gastric cancer. PMID: 25026207 Ref: Comprehensive molecular characterization of gastric adenocarcinoma. PMID: 25079317 |
Ref: Chemotherapy-Induced miRNA-29c/Catenin-delta Signaling Suppresses Metastasis in Gastric Cancer. PMID: 25634213 Ref: [Under hypoxia condition contactin-1 regulates migration of MKN45 cells through RhoA pathway]. PMID: 25916117 Ref: The Correlation Between RhoA Expression and Clinicopathological Characteristics in Gastric Cancer Patients After Curative Surgery. PMID: 26013205 Ref: Depletion of histone deacetylase 1 inhibits metastatic abilities of gastric cancer cells by regulating the miR-34a/CD44 pathway. PMID: 26035691 Ref: Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma. PMID: 26073375 Ref: Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity. PMID: 26146084 Ref: ODAM inhibits RhoA-dependent invasion in breast cancer. PMID: 26358398 Ref: Contactin 1: A potential therapeutic target and biomarker in gastric cancer. PMID: 26361417 Ref: Gene mutations in gastric cancer: a review of recent next-generation sequencing studies. PMID: 26364057 Ref: Effect of RhoA gene silencing on proliferation and migration of gastric MGC-803 cells. PMID: 26550428 |
Ref: RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases. PMID: 25823974 Ref: Clinicopathological characteristics of RHOA mutations in a Central European gastric cancer cohort. PMID: 26251521 Ref: RHOA mutation may be associated with diffuse-type gastric cancer progression, but is it gain or loss? PMID: 26296386 Ref: Fbxw7 regulates tumor apoptosis, growth arrest and the epithelial-to-mesenchymal transition in part through the RhoA signaling pathway in gastric cancer. PMID: 26458995 Ref: Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites. PMID: 26811494 Ref: CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells. PMID: 26830684 Ref: Comprehensive mutation profiling of mucinous gastric carcinoma. PMID: 27313181 Ref: Increased RhoA Activity Predicts Worse Overall Survival in Patients Undergoing Surgical Resection for Lauren Diffuse-Type Gastric Adenocarcinoma. PMID: 27364501 Ref: MicroRNAs in hereditary diffuse gastric cancer. PMID: 27446532 Ref: Inhibition of Rho-Associated Kinase 1/2 Attenuates Tumor Growth in Murine Gastric Cancer. PMID: 27566106 Ref: Cross-linked hyaluronic acid gel inhibits metastasis and growth of gastric and hepatic cancer cells: in vitro and in vivo studies. PMID: 27589842 Ref: Unsupervised detection of cancer driver mutations with parsimony-guided learning. PMID: 27618449 Ref: Variegated RHOA mutations in human cancers. PMID: 27693615 Ref: C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA. PMID: 27756879 Ref: Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer. PMID: 27806312 Ref: MiR-31 Regulates Rho-Associated Kinase-Myosin Light Chain (ROCK-MLC) Pathway and Inhibits Gastric Cancer Invasion: Roles of RhoA. PMID: 27904131 |
Ref: Gastrokine 1 inhibits gastric cancer cell migration and invasion by downregulating RhoA expression. PMID: 27250838 Ref: Genomic landscape of gastric cancer: molecular classification and potential targets. PMID: 27460193 Ref: Rho GTPases: Anti- or pro-neoplastic targets? PMID: 27991930 Ref: Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers. PMID: 28522256 Ref: YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis. PMID: 28538170 Ref: Expressions of Ras Homolog Gene Family, Member A (RhoA) and Cyclooxygenase-2 (COX-2) Proteins in Early Gastric Cancer and Their Role in the Development of Gastric Cancer. PMID: 28624843 Ref: P53 and Protein Phosphorylation Regulate the Oncogenic Role of Epithelial Cell Transforming 2 (ECT2). PMID: 28654632 Ref: MicroRNA-31 inhibits tumor invasion and metastasis by targeting RhoA in human gastric cancer. PMID: 28656284 Ref: MicroRNA-31 inhibits RhoA-mediated tumor invasion and chemotherapy resistance in MKN-45 gastric adenocarcinoma cells. PMID: 28836853 Ref: MicroRNA-647 Targets SRF-MYH9 Axis to Suppress Invasion and Metastasis of Gastric Cancer. PMID: 28900514 |
Ref: Gastric poorly cohesive carcinoma: a correlative study of mutational signatures and prognostic significance based on histopathological subtypes. PMID: 28873240 Ref: Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer. PMID: 29095547 Ref: Aberrant alternative splicing of RHOA is associated with loss of its expression and activity in diffuse-type gastric carcinoma cells. PMID: 29247652 Ref: Identification of genomic aberrations associated with lymph node metastasis in diffuse-type gastric cancer. PMID: 29622765 Ref: PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis. PMID: 29683214 Ref: Inhibition of gastric cancer by local anesthetic bupivacaine through multiple mechanisms independent of sodium channel blockade. PMID: 29684861 Ref: Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer. PMID: 29687789 Ref: Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer. PMID: 29743821 Ref: Identification of recurrent risk-related genes and establishment of support vector machine prediction model for gastric cancer. PMID: 29788739 Ref: DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation. PMID: 29796182 Ref: Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice. PMID: 29864961 Ref: Suppression of BMX-ARHGAP fusion gene inhibits epithelial-mesenchymal transition in gastric cancer cells via RhoA-mediated blockade of JAK/STAT axis. PMID: 30216523 Ref: A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening. PMID: 30344100 |