Primary Site >> Colorectal Cancer
Gene >> RHOA
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Ref: Utilization of multiple polyadenylation signals in the human RHOA protooncogene. PMID: 8039707 |
Ref: Activated Rac1 selectively up-regulates the expression of integrin alpha6beta4 and induces cell adhesion and membrane ruffles of nonadherent colon cancer Colo201 cells. PMID: 10585277 |
Ref: RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism. PMID: 10648558 Ref: Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells. PMID: 10732765 Ref: Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. PMID: 11053255 |
Ref: Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells. PMID: 11156951 |
Ref: Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. PMID: 11844789 Ref: Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells. PMID: 11895868 Ref: [RhoA gene expression in colorectal carcinoma]. PMID: 11953197 Ref: Bombesin stimulates invasion and migration of Isreco1 colon carcinoma cells in a Rho-dependent manner. PMID: 12183443 Ref: Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways. PMID: 12360401 |
Ref: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. PMID: 12892714 Ref: Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor. PMID: 14598891 Ref: Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility. PMID: 14609961 |
Ref: Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion. PMID: 14630701 Ref: LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane. PMID: 15057873 Ref: Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. PMID: 15059978 Ref: Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. PMID: 15604264 |
Ref: Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. PMID: 16091733 Ref: A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. PMID: 16103880 Ref: [Effect of NGX6 on gene expression profile of colon carcinoma cell line HT-29]. PMID: 16159426 Ref: Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. PMID: 16322241 |
Ref: Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. PMID: 16368433 Ref: PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. PMID: 16540666 Ref: Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. PMID: 16715134 Ref: Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts. PMID: 16928828 Ref: RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. PMID: 17178865 |
Ref: MAGI-3 regulates LPA-induced activation of Erk and RhoA. PMID: 16904289 Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. PMID: 17390031 Ref: PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. PMID: 17409395 |
Ref: The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. PMID: 17597401 Ref: Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. PMID: 18172863 Ref: Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion. PMID: 18423981 Ref: Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. PMID: 18463201 Ref: LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin. PMID: 18702663 Ref: Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. PMID: 18767036 Ref: Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. PMID: 18922892 Ref: RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells. PMID: 18922976 Ref: RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. PMID: 19015318 |
Ref: Inhibitory effects of adenovirus mediated tandem expression of RhoA and RhoC shRNAs in HCT116 cells. PMID: 19374769 Ref: Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters. PMID: 19499974 Ref: Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. PMID: 19773752 Ref: Effects of lysophosphatidic acid on human colon cancer cells and its mechanisms of action. PMID: 19777613 Ref: Aquaporin-1 activity of plasma membrane affects HT20 colon cancer cell migration. PMID: 19787701 |
Ref: Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. PMID: 19626588 Ref: Transforming growth factor-beta1 modulates metalloproteinase-2 and -9, nitric oxide, RhoA and alpha-smooth muscle actin expression in colon adenocarcinoma cells. PMID: 19947919 Ref: Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. PMID: 20017136 Ref: Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells. PMID: 20202822 Ref: The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling. PMID: 20223287 Ref: [Effects of K-ras gene mutation on colon cancer cell line Caco-2 metastasis by regulating E-cadherin/beta-catenin/p120 protein complex formation and RhoA protein activity]. PMID: 20236587 Ref: A central role for RhoA during oligodendroglial maturation in the switch from netrin-1-mediated chemorepulsion to process elaboration. PMID: 20367748 Ref: PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells. PMID: 20519451 Ref: Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo. PMID: 20828398 |
Ref: miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells. PMID: 21186079 Ref: Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion. PMID: 21273532 Ref: Cudratricusxanthone G inhibits human colorectal carcinoma cell invasion by MMP-2 down-regulation through suppressing activator protein-1 activity. PMID: 21377450 Ref: mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. PMID: 21430067 Ref: Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells. PMID: 21722395 Ref: The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth. PMID: 21849478 Ref: BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. PMID: 21943101 Ref: Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells. PMID: 21968138 |
Ref: Clinical significance of Rho GDP dissociation inhibitor 2 in colorectal carcinoma. PMID: 21698524 Ref: The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1. PMID: 22139079 Ref: Matrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signaling. PMID: 22363817 Ref: Rho GTPase signaling in the development of colorectal cancer. PMID: 22467564 Ref: Comparative label-free LC-MS/MS analysis of colorectal adenocarcinoma and metastatic cells treated with 5-fluorouracil. PMID: 22623418 Ref: Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins. PMID: 22649559 Ref: GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation. PMID: 22750095 Ref: Role of km23-1 in RhoA/actin-based cell migration. PMID: 23079622 Ref: Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity. PMID: 23144867 |
Ref: Cell fusion promotes chemoresistance in metastatic colon carcinoma. PMID: 22751128 Ref: Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis. PMID: 23280667 Ref: Proteogenomic analysis of human colon carcinoma cell lines LIM1215, LIM1899, and LIM2405. PMID: 23458625 Ref: Enteropathogenic Escherichia coli-induced macrophage inhibitory cytokine 1 mediates cancer cell survival: an in vitro implication of infection-linked tumor dissemination. PMID: 23503457 Ref: MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway. PMID: 23615712 Ref: CCR4 mediates CCL17 (TARC)-induced migration of human colon cancer cells via RhoA/Rho-kinase signaling. PMID: 23649168 Ref: Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma. PMID: 23652727 Ref: Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. PMID: 24279335 Ref: Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PMID: 24386239 |
Ref: Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity. PMID: 23644655 Ref: Piezoelectric ceramic (PZT) modulates axonal guidance growth of rat cortical neurons via RhoA, Rac1, and Cdc42 pathways. PMID: 24203571 Ref: PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity. PMID: 24284071 Ref: HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. PMID: 24582560 Ref: TAp63 suppress metastasis via miR-133b in colon cancer cells. PMID: 24594999 Ref: Increased diacylglycerol kinase zeta expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion. PMID: 24646293 Ref: Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells. PMID: 24676941 Ref: Galpha13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration. PMID: 24958816 Ref: Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer. PMID: 25360999 Ref: RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. PMID: 25413277 |
Ref: A novel role for Plk4 in regulating cell spreading and motility. PMID: 25174401 Ref: Gastrin-stimulated Galpha13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells. PMID: 25922072 Ref: Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer. PMID: 26258642 Ref: Effect of shRNA targeted against RhoA on proliferation and migration of human colonic cancer cells. PMID: 26261596 Ref: Correction to "Galpha(1)(3)/PDZ-RhoGEF/RhoA Signaling Is Essential for Gastrin-Releasing Peptide Receptor-Mediated Colon Cancer Cell Migration". PMID: 26450926 Ref: Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway. PMID: 26735435 |
Ref: RhoA is associated with invasion and poor prognosis in colorectal cancer. PMID: 26648547 Ref: Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1. PMID: 26747707 Ref: Direct measurement of oscillatory RhoA activity in embryonic cortical neurons stimulated with the axon guidance cue netrin-1 using fluorescence resonance energy transfer. PMID: 26787017 Ref: Bioinformatic exploration of MTA1-regulated gene networks in colon cancer. PMID: 27052252 Ref: Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer. PMID: 27246245 Ref: Upregulated STAT3 and RhoA signaling in colorectal cancer (CRC) regulate the invasion and migration of CRC cells. PMID: 27249601 Ref: Regulation of the RhoA/ROCK/AKT/beta-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma. PMID: 27277835 Ref: Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation. PMID: 27333992 Ref: alpha-TEA inhibits the growth and motility of human colon cancer cells via targeting RhoA/ROCK signaling. PMID: 27432222 Ref: MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway. PMID: 27517626 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis. PMID: 27720713 Ref: RhoA regulates resistance to irinotecan by regulating membrane transporter and apoptosis signaling in colorectal cancer. PMID: 27888624 Ref: Negative feedback between TAp63 and Mir-133b mediates colorectal cancer suppression. PMID: 27894087 Ref: Vincristine promotes migration and invasion of colorectal cancer HCT116 cells through RhoA/ROCK/ Myosin light chain pathway. PMID: 27894406 Ref: New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract. PMID: 28174704 |
Ref: Expression of orphan GPR56 correlates with tumor progression in human epithelial ovarian cancer. PMID: 27881002 Ref: Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo. PMID: 28138708 Ref: MiR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting RhoA. PMID: 28146427 Ref: A crosstalk between muscarinic and CRF2 receptors regulates cellular adhesion properties of human colon cancer cells. PMID: 28432022 Ref: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats. PMID: 28526701 Ref: Genome-wide network-based pathway analysis of CSF t-tau/Abeta1-42 ratio in the ADNI cohort. PMID: 28558704 Ref: Cell type-dependent HIF1 alpha-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells. PMID: 28562340 Ref: Danshen improves survival of patients with colon cancer and dihydroisotanshinone I inhibit the proliferation of colon cancer cells via apoptosis and skp2 signaling pathway. PMID: 28807849 Ref: The ILK-MMP9-MRTF axis is crucial for EndMT differentiation of endothelial cells in a tumor microenvironment. PMID: 28893556 Ref: PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition. PMID: 28915620 Ref: miR-223 promotes colon cancer by directly targeting p120 catenin. PMID: 28969027 Ref: Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells. PMID: 29184140 Ref: LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics. PMID: 29312635 |
Ref: Procaine Inhibits the Proliferation and Migration of Colon Cancer Cells Through Inactivation of the ERK/MAPK/FAK Pathways by Regulation of RhoA. PMID: 28492141 Ref: Ezrin Orchestrates Signal Transduction in Airway Cells. PMID: 28702704 Ref: Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer. PMID: 29095547 Ref: Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer. PMID: 29206819 Ref: 133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. PMID: 29343721 Ref: Carboxylated graphene oxide promoted axonal guidance growth by activating Netrin-1/deleted in colorectal cancer signaling in rat primary cultured cortical neurons. PMID: 29377591 Ref: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway. PMID: 29454618 Ref: P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. PMID: 29454793 Ref: Kruppel-like factor 4 mediates cellular migration and invasion by altering RhoA activity. PMID: 29498307 Ref: The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells. PMID: 29772566 Ref: PRP4 kinase induces actin rearrangement and epithelial-mesenchymal transition through modulation of the actin-binding protein cofilin. PMID: 29787735 Ref: Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a beta1-integrin-FAK-YAP1/TAZ signaling pathway. PMID: 29872721 Ref: Cofilin-1 signaling mediates epithelial-mesenchymal transition by promoting actin cytoskeleton reorganization and cell-cell adhesion regulation in colorectal cancer cells. PMID: 30296500 |