Primary Site >> Colorectal Cancer
Gene >> RASSF1
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Ref: Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas. PMID: 11668500 |
Ref: Translational oncogenomics: toward rational therapeutic decision-making. PMID: 11880707 Ref: K-ras mutations and RASSF1A promoter methylation in colorectal cancer. PMID: 12032847 Ref: Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer. PMID: 12370819 |
Ref: SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. PMID: 12615722 Ref: Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. PMID: 12810640 |
Ref: The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. PMID: 15075335 Ref: Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. PMID: 15122305 Ref: Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors. PMID: 15480433 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. PMID: 15760919 Ref: CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations. PMID: 15806169 Ref: Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer. PMID: 16007118 Ref: The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. PMID: 16012945 |
Ref: Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk. PMID: 16125301 Ref: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. PMID: 16369045 Ref: Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma. PMID: 16374457 Ref: Epigenetic alterations in RASSF1A in human aberrant crypt foci. PMID: 16513682 Ref: Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. PMID: 16645205 Ref: Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers. PMID: 16918136 Ref: Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer. PMID: 16969349 Ref: Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients. PMID: 17108212 Ref: Promoter methylation precedes chromosomal alterations in colorectal cancer development. PMID: 17167178 |
Ref: Promoter methylation status of multiple genes in uveal melanoma. PMID: 17898258 Ref: Promoter hypermethylation of tumor-related genes in sporadic colorectal cancer in young patients. PMID: 18365548 |
Ref: Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. PMID: 18048385 Ref: Detection of RASSF1A promoter hypermethylation in serum from gastric and colorectal adenocarcinoma patients. PMID: 18494062 Ref: Epigenetic signatures of familial cancer are characteristic of tumor type and family category. PMID: 18559504 Ref: RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A. PMID: 18592002 |
Ref: Gene-specific methylation: potential markers for colorectal cancer. PMID: 19404924 |
Ref: Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. PMID: 20098741 Ref: Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers. PMID: 20131317 Ref: Hypermethylation of RARbeta2 correlates with high COX-2 expression and poor prognosis in patients with colorectal carcinoma. PMID: 20571967 Ref: A gene expression signature for chemoradiosensitivity of colorectal cancer cells. PMID: 20970032 |
Ref: Promoter hypermethylation of RASSF1A, MGMT, and HIC-1 genes in benign and malignant colorectal tumors. PMID: 21274674 Ref: MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. PMID: 21565830 Ref: Hypermethylation of promoter regions of the APC1A and p16INK4a genes in relation to prognosis and tumor characteristics in cervical cancer patients. PMID: 21674126 Ref: Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. PMID: 22195963 |
Ref: DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps. PMID: 22020530 Ref: Epigenetic markers of early tumor development. PMID: 22359284 Ref: The cellular apoptosis susceptibility CAS/CSE1L gene protects ovarian cancer cells from death by suppressing RASSF1C. PMID: 22389439 Ref: Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation. PMID: 22433712 Ref: [Alterations of expression level of RASSFIA gene in primary epithelial tumors of various locations]. PMID: 22670522 Ref: Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis. PMID: 22710434 Ref: Quantitative analysis of cancer-associated gene methylation connected to risk factors in Korean colorectal cancer patients. PMID: 22880157 Ref: beta-catenin and K-ras mutations and RASSF1A promoter methylation in Taiwanese colorectal cancer patients. PMID: 23009572 Ref: Methylation of the polycomb group target genes is a possible biomarker for favorable prognosis in colorectal cancer. PMID: 23010642 |
Ref: Colorectal cancer and RASSF family--a special emphasis on RASSF1A. PMID: 22733432 Ref: Genetic and epigenetic alterations in primary colorectal cancers and related lymph node and liver metastases. PMID: 22786759 Ref: DNA methylation of the p14ARF, RASSF1A and APC1A genes as an independent prognostic factor in colorectal cancer patients. PMID: 23128528 Ref: Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening. PMID: 23320751 Ref: Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population. PMID: 23573237 Ref: Loss of RASSF1A expression in colorectal cancer and its association with K-ras status. PMID: 23865079 Ref: Toward a comprehensive and systematic methylome signature in colorectal cancers. PMID: 23975090 |
Ref: Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism. PMID: 24500500 Ref: Aberrant promoter methylation of RASSF1A gene may be correlated with colorectal carcinogenesis: a meta-analysis. PMID: 24566684 Ref: Promoter methylation of the RASSF1A gene may contribute to colorectal cancer susceptibility: a meta-analysis of cohort studies. PMID: 24621386 |
Ref: Rectal cancer profiling identifies distinct subtypes in India based on age at onset, genetic, epigenetic and clinicopathological characteristics. PMID: 25418895 Ref: Association of HPV with genetic and epigenetic alterations in colorectal adenocarcinoma from Indian population. PMID: 25647260 Ref: Application of artificial neural networks to link genetic and environmental factors to DNA methylation in colorectal cancer. PMID: 25942531 |
Ref: Germline polymorphisms in genes involved in the Hippo pathway as recurrence biomarkers in stages II/III colon cancer. PMID: 26370619 Ref: [Methylation status of PCDH10 and RASSF1A gene promoters in colorectal cancer]. PMID: 26875923 Ref: Epigenetic silencing of miR-181b contributes to tumorigenicity in colorectal cancer by targeting RASSF1A. PMID: 26935905 Ref: Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review. PMID: 26998585 Ref: Retraction: Promoter Methylation of the RASSF1A Gene may Contribute to Colorectal Cancer Susceptibility: A Meta-Analysis of Cohort Studies. PMID: 27346737 Ref: Delineating the effect of demethylating agent 5-aza-2'-deoxycytidine on human Caco-2 colonic carcinoma cells. PMID: 27347114 Ref: Methylation status of the APC and RASSF1A promoter in cell-free circulating DNA and its prognostic role in patients with colorectal cancer. PMID: 27347211 Ref: beta-catenin interaction with NHERF1 and RASSF1A methylation in metastatic colorectal cancer patients. PMID: 27765918 |
Ref: Methylation of the Tumor Suppressor Genes HIC1 and RassF1A Clusters Independently From the Methylation of Polycomb Target Genes in Colon Cancer. PMID: 26671036 Ref: The significance of DNA methylation profile in metastasis-related genes for the progression of colorectal cancer. PMID: 28364795 Ref: Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa. PMID: 28533824 Ref: Screening and identification of a tumor specific methylation phenotype in the colorectal laterally spreading tumor. PMID: 28678324 Ref: Promoter Methylation of RASSF1A indicates Prognosis for Patients with Stage II and III Colorectal Cancer Treated with Oxaliplatin-Based Chemotherapy. PMID: 29128865 |
Ref: A genetic variant in Rassf1a predicts outcome in mCRC patients treated with cetuximab plus chemotherapy: results from FIRE-3 and JACCRO 05 and 06 trials. PMID: 27698403 Ref: The prognostic efficacy of cell-free DNA hypermethylation in colorectal cancer. PMID: 29467946 Ref: A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathway. PMID: 29486770 Ref: Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation. PMID: 30045022 Ref: Diagnostic value of RASSF1A hypermethylation in colorectal cancer: a meta-analysis. PMID: 30082160 Ref: RASSF1A suppresses colorectal tumor cell growth through p53-dependent p21(WAF1) activation. PMID: 30226276 Ref: Metformin Reshapes the Methylation Profile in Breast and Colorectal Cancer Cells PMID: 30371994 |