Primary Site >> Colorectal Cancer
Gene >> RAF1
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Ref: Activation of rat and human c-raf(-1) by rearrangement. PMID: 3332022 |
Ref: Activation of human c-raf-1 by replacing the N-terminal region with different sequences. PMID: 2955285 |
Ref: Multiple polyps of esophagus, stomach, colon, and rectum accompanying rectal cancer in a patient with constitutional chromosomal inversion. PMID: 8431846 |
Ref: Raf-1 kinase, epidermal growth factor receptors, and mutant Ras proteins in colonic carcinomas. PMID: 8654136 Ref: Suppression of a human colon cancer cell line by introduction of an exogenous NF1 gene. PMID: 8665528 |
Ref: Common patterns of genetic evolution in human solid tumors. PMID: 9298807 |
Ref: Abrogation of c-Raf expression induces apoptosis in tumor cells. PMID: 9583688 |
Ref: Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin. PMID: 12232764 |
Ref: Raf proteins and cancer: B-Raf is identified as a mutational target. PMID: 12781369 Ref: Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells. PMID: 14625389 |
Ref: Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. PMID: 14688025 Ref: Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells. PMID: 14747693 Ref: Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway. PMID: 14981539 Ref: [Complex forms of immune insufficiency to some cytokines (TNF-alpha, interferons) in colorectal cancers as exemplified by the COLO 205 cell line. Mechanism of resistance with special reference to signaling proteins and cytokines]. PMID: 15577750 |
Ref: Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation. PMID: 16294035 |
Ref: APC inhibits ERK pathway activation and cellular proliferation induced by RAS. PMID: 16478791 |
Ref: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. PMID: 17143621 Ref: Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. PMID: 17431102 |
Ref: SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. PMID: 18064648 Ref: Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. PMID: 18413805 |
Ref: Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. PMID: 18931700 Ref: Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors. PMID: 19492075 Ref: [Phosphatidylethanolamine-binding protein (PEBP) in basic and clinical study]. PMID: 19803424 Ref: Human cancer protein-protein interaction network: a structural perspective. PMID: 20011507 |
Ref: Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells. PMID: 20188103 |
Ref: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. PMID: 22448344 Ref: Regorafenib for cancer. PMID: 22577890 Ref: Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients. PMID: 22879877 Ref: Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells. PMID: 22922669 Ref: Association of polymorphisms in microRNA-binding sites and colorectal cancer in an Iranian population. PMID: 22939228 Ref: Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. PMID: 22984537 Ref: MAP kinase genes and colon and rectal cancer. PMID: 23027623 |
Ref: Novel biomarkers for the prediction of metastasis in colorectal cancer. PMID: 23530884 Ref: Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells. PMID: 23629727 Ref: Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PMID: 23637631 Ref: Phase I/II RAF kinase inhibitors in cancer therapy. PMID: 23642225 Ref: Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions. PMID: 23844038 Ref: Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer. PMID: 23859041 Ref: Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway. PMID: 23905676 |
Ref: PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. PMID: 24530606 Ref: The preclinical development of regorafenib for the treatment of colorectal cancer. PMID: 24896071 Ref: Development of siRNA payloads to target KRAS-mutant cancer. PMID: 25100204 Ref: The influence of the CHIEF pathway on colorectal cancer-specific mortality. PMID: 25541970 |
Ref: Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. PMID: 24292678 Ref: MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase. PMID: 25355599 Ref: Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells. PMID: 25794709 Ref: Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation. PMID: 26058013 Ref: Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors. PMID: 26351322 |
Ref: Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation. PMID: 26959608 Ref: Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model. PMID: 26970558 Ref: IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF-1 degradation by miR-195. PMID: 27153315 Ref: Design, synthesis, and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents. PMID: 27255180 Ref: Human Blood Autoantibodies in the Detection of Colorectal Cancer. PMID: 27383396 |
Ref: Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib. PMID: 27321184 Ref: Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer. PMID: 27670374 Ref: LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. PMID: 27999210 Ref: Circular RNA ciRS-7-A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer. PMID: 28174233 Ref: Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance. PMID: 28368067 Ref: Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia. PMID: 28524162 Ref: AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes. PMID: 28536078 Ref: Discovery of a novel pan-RAF inhibitor with potent anti-tumor activity in preclinical models of BRAF(V600E) mutant cancer. PMID: 28645859 |
Ref: Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats. PMID: 29269057 Ref: Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis. PMID: 29443735 Ref: Construction of key signal regulatory network in metastatic colorectal cancer. PMID: 29464057 Ref: A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer. PMID: 29619072 Ref: Nuclear localized Raf1 isoform alters DNA-dependent protein kinase activity and the DNA damage response. PMID: 30106602 Ref: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. PMID: 30382763 |