Primary Site >> Colorectal Cancer
Gene >> RAD50
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Ref: Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. PMID: 10362364 |
Ref: Evolution of instability at coding and non-coding repeat sequences in human MSI-H colorectal cancers. PMID: 11181575 Ref: Frameshift mutations at mononucleotide repeats in RAD50 recombinational DNA repair gene in colorectal cancers with microsatellite instability. PMID: 11429044 |
Ref: Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. PMID: 15048091 |
Ref: Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas. PMID: 16025146 |
Ref: Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. PMID: 16421660 Ref: Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. PMID: 16905549 |
Ref: The MRE11/RAD50/NBS1 complex destabilization in Lynch-syndrome patients. PMID: 17534377 |
Ref: The different roles of hRAD50 in microsatellite stable and unstable colorectal cancers. PMID: 18219098 Ref: A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. PMID: 18256278 Ref: The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer. PMID: 18606567 Ref: RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer. PMID: 18830935 Ref: Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines. PMID: 18941461 |
Ref: Mutations in the circadian gene CLOCK in colorectal cancer. PMID: 20551151 |
Ref: Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. PMID: 22643064 |
Ref: Clinicopathological significance of BTF3 expression in colorectal cancer. PMID: 23532689 |
Ref: The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks. PMID: 24577941 |
Ref: Prognostic Significance and Molecular Features of Colorectal Mucinous Adenocarcinomas: A Strobe-Compliant Study. PMID: 26705231 |
Ref: Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival. PMID: 29189711 |
Ref: AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. PMID: 28967905 Ref: Targeting RAD50 increases sensitivity to radiotherapy in colorectal cancer cells. PMID: 29322791 Ref: Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis. PMID: 30176843 |