Primary Site >> Colorectal Cancer
Gene >> RAC1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Formulation, stability, and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugate of thioether phospholipid. PMID: 2364392 |
Ref: 1-beta-D-arabinofuranosylcytosine conjugates of ether and thioether phospholipids. A new class of ara-C prodrug with improved antitumor activity. PMID: 1819747 |
Ref: Activated Rac1 selectively up-regulates the expression of integrin alpha6beta4 and induces cell adhesion and membrane ruffles of nonadherent colon cancer Colo201 cells. PMID: 10585277 |
Ref: Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. PMID: 11053255 |
Ref: Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. PMID: 11790459 Ref: The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. PMID: 11817894 Ref: Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. PMID: 11844789 Ref: The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. PMID: 12149262 Ref: Complex formation of IQGAP1 with E-cadherin/catenin during cohort migration of carcinoma cells. Its possible association with localized release from cell-cell adhesion. PMID: 12189501 Ref: Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways. PMID: 12360401 |
Ref: Differential effects between amphoterin and advanced glycation end products on colon cancer cells. PMID: 12640679 Ref: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. PMID: 12892714 Ref: Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling. PMID: 14506233 |
Ref: DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. PMID: 14976132 Ref: Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. PMID: 14978110 Ref: Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway. PMID: 15037605 Ref: LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane. PMID: 15057873 Ref: Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. PMID: 15377999 Ref: Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. PMID: 15516977 |
Ref: Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. PMID: 15743787 Ref: Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. PMID: 15788770 Ref: Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. PMID: 16091733 |
Ref: Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells. PMID: 16551621 |
Ref: Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein. PMID: 17126424 Ref: Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. PMID: 17145773 Ref: Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. PMID: 17363564 Ref: PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. PMID: 17409395 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 Ref: Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. PMID: 17599059 Ref: Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. PMID: 17635998 Ref: Differential expression of Rac1 identifies its target genes and its contribution to progression of colorectal cancer. PMID: 17766170 Ref: [Role of Rac1 activation in migration and invasion of colorectal cancer cell line SW480]. PMID: 18246795 |
Ref: The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. PMID: 17597401 Ref: Nox1 downstream of 12-lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells. PMID: 18076063 Ref: A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells. PMID: 18165265 Ref: Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance. PMID: 18212043 Ref: Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1. PMID: 18392556 Ref: Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion. PMID: 18423981 Ref: The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1. PMID: 18463161 Ref: Activation of NADPH oxidase 1 in tumour colon epithelial cells. PMID: 18518859 Ref: B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. PMID: 18602919 Ref: Increased Rac1b expression sustains colorectal tumor cell survival. PMID: 18644982 Ref: Rac regulates the interaction of fascin with protein kinase C in cell migration. PMID: 18716283 Ref: Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. PMID: 18767036 Ref: Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. PMID: 18826597 Ref: Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells. PMID: 18929641 |
Ref: Inhibition of migration and invasion of colorectal cancer cells via deletion of Rac1 with RNA interference. PMID: 19009236 Ref: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. PMID: 19151759 Ref: Expression of Tiam1 and VEGF-C correlates with lymphangiogenesis in human colorectal carcinoma. PMID: 19276682 Ref: NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells. PMID: 19308044 Ref: P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. PMID: 19415746 Ref: Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells. PMID: 19483190 Ref: Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase. PMID: 19525225 Ref: Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression. PMID: 19561401 Ref: Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. PMID: 19602482 Ref: [The effect of Rac1 siRNA on the biological behaviors of gastrointestinal cancer cells]. PMID: 19764550 |
Ref: The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. PMID: 19908241 Ref: Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. PMID: 20017136 Ref: Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection. PMID: 20111723 Ref: TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways. PMID: 20118200 Ref: PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells. PMID: 20519451 Ref: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. PMID: 20530489 Ref: p21-activated kinase 5 inhibits camptothecin-induced apoptosis in colorectal carcinoma cells. PMID: 20567954 Ref: [Effect of small interfering RNA targeting Rac1 gene on colony formation of SW480 cells in vitro]. PMID: 20584673 Ref: PTHrP promotes colon cancer cell migration and invasion in an integrin alpha6beta4-dependent manner through activation of Rac1. PMID: 20637541 Ref: Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells. PMID: 20841469 |
Ref: Cudratricusxanthone G inhibits human colorectal carcinoma cell invasion by MMP-2 down-regulation through suppressing activator protein-1 activity. PMID: 21377450 Ref: mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. PMID: 21430067 Ref: Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway. PMID: 21621326 Ref: The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth. PMID: 21849478 Ref: [The affect of Si-Rac1b on the malignant biological behaviors of colorectal cancer cell]. PMID: 21866624 Ref: BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. PMID: 21943101 |
Ref: Clinical significance of Rho GDP dissociation inhibitor 2 in colorectal carcinoma. PMID: 21698524 Ref: A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells. PMID: 21822311 Ref: Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis. PMID: 22179719 Ref: PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation. PMID: 22252525 Ref: A crucial role for Nox 1 in redox-dependent regulation of Wnt-beta-catenin signaling. PMID: 22278940 Ref: Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing. PMID: 22345078 Ref: Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. PMID: 22419013 Ref: Rho GTPase signaling in the development of colorectal cancer. PMID: 22467564 Ref: The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction. PMID: 22692424 Ref: Murine colon proteome and characterization of the protein pathways. PMID: 22929016 Ref: Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity. PMID: 23144867 |
Ref: Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth. PMID: 23230270 Ref: DADS downregulates the Rac1-ROCK1/PAK1-LIMK1-ADF/cofilin signaling pathway, inhibiting cell migration and invasion. PMID: 23233092 Ref: RAC1b overexpression in papillary thyroid carcinoma: a role to unravel. PMID: 23482591 Ref: Small interfering RNA targeting Rac1 sensitizes colon cancer to dihydroartemisinin-induced cell cycle arrest and inhibited cell migration by suppressing NFkappaB activity. PMID: 23559092 Ref: APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression. PMID: 23570874 Ref: ROS production and NF-kappaB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. PMID: 23665120 Ref: The other face of ROS: a driver of stem cell expansion in colorectal cancer. PMID: 23746969 Ref: Testosterone induced apoptosis in colon cancer cells is regulated by PI3K/Rac1 signaling. PMID: 23770942 Ref: Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP). PMID: 23864657 Ref: Rac1 drives intestinal stem cell proliferation and regeneration. PMID: 23974108 Ref: Inhibition of angiopoietin 2 attenuates lumen formation of tumour-associated vessels in vivo. PMID: 23982687 Ref: The Cdc42/Rac nucleotide exchange factor protein beta1Pix (Pak-interacting exchange factor) modulates beta-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of beta1PIX with beta-catenin. PMID: 24129564 Ref: The miR-1-NOTCH3-Asef pathway is important for colorectal tumor cell migration. PMID: 24244701 Ref: Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. PMID: 24279335 Ref: Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PMID: 24386239 |
Ref: Piezoelectric ceramic (PZT) modulates axonal guidance growth of rat cortical neurons via RhoA, Rac1, and Cdc42 pathways. PMID: 24203571 Ref: miR-320a suppresses colorectal cancer progression by targeting Rac1. PMID: 24265291 Ref: PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity. PMID: 24284071 Ref: Increased diacylglycerol kinase zeta expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion. PMID: 24646293 Ref: Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCalpha and FAK/Fyn in promoting mesenchymal stem cell motility. PMID: 24738865 Ref: RAC1b overexpression correlates with poor prognosis in KRAS/BRAF WT metastatic colorectal cancer patients treated with first-line FOLFOX/XELOX chemotherapy. PMID: 24833563 Ref: Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan alpha2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro. PMID: 25056432 Ref: [Construction of colorectal cancer cell line stably expressing mir-101 and identification of the target gene of mir-101]. PMID: 25057058 Ref: Radixin enhances colon cancer cell invasion by increasing MMP-7 production via Rac1-ERK pathway. PMID: 25136657 Ref: Changes of cytoskeleton and cell cycle in Lovo cells via deletion of Rac1. PMID: 25171475 |
Ref: A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. PMID: 25351103 Ref: MicroRNA-320b promotes colorectal cancer proliferation and invasion by competing with its homologous microRNA-320a. PMID: 25458952 Ref: Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1. PMID: 25529012 Ref: Gene silencing of Rac1 with RNA interference mediated by ultrasound and microbubbles in human LoVo cells: evaluation of cell invasion inhibition and metastatic. PMID: 25673262 Ref: An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. PMID: 25746002 Ref: RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric cancer cells. PMID: 25901126 Ref: ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma. PMID: 25973293 Ref: Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. PMID: 26126266 Ref: Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. PMID: 26234763 Ref: Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1. PMID: 26323693 Ref: Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells. PMID: 26341689 Ref: Down-regualtion of miR-106b induces epithelial-mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer. PMID: 26617763 |
Ref: Direct measurement of oscillatory RhoA activity in embryonic cortical neurons stimulated with the axon guidance cue netrin-1 using fluorescence resonance energy transfer. PMID: 26787017 Ref: A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1. PMID: 26860615 Ref: Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways. PMID: 26918455 Ref: SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline. PMID: 27102434 Ref: The WASF3-NCKAP1-CYFIP1 Complex Is Essential for Breast Cancer Metastasis. PMID: 27432794 Ref: Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer. PMID: 27657889 Ref: Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma. PMID: 27696383 Ref: Blocking hepatic metastases of colon cancer cells using an shRNA against Rac1 delivered by activatable cell-penetrating peptide. PMID: 27791203 |
Ref: Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer. PMID: 28218473 Ref: Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway. PMID: 28250131 Ref: Cell type-dependent HIF1 alpha-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells. PMID: 28562340 Ref: LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. PMID: 28739799 Ref: Identification of Differentially Expressed Splice Variants by the Proteogenomic Pipeline Splicify. PMID: 28747380 Ref: The ILK-MMP9-MRTF axis is crucial for EndMT differentiation of endothelial cells in a tumor microenvironment. PMID: 28893556 Ref: PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition. PMID: 28915620 Ref: LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics. PMID: 29312635 |
Ref: RCC2 is a novel p53 target in suppressing metastasis. PMID: 28869598 Ref: shRNA-induced silencing of Ras-related C3 botulinum toxin substrate 1 inhibits the proliferation of colon cancer cells through upregulation of BAD and downregulation of cyclin D1. PMID: 29286138 Ref: Carboxylated graphene oxide promoted axonal guidance growth by activating Netrin-1/deleted in colorectal cancer signaling in rat primary cultured cortical neurons. PMID: 29377591 Ref: Protein Kinase C-zeta stimulates colorectal cancer cell carcinogenesis via PKC-zeta/Rac1/Pak1/beta-Catenin signaling cascade. PMID: 29408512 Ref: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway. PMID: 29454618 Ref: Delineating the underlying molecular mechanisms and key genes involved in metastasis of colorectal cancer via bioinformatics analysis. PMID: 29517105 Ref: The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells. PMID: 29772566 Ref: Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis. PMID: 29867200 Ref: RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3. PMID: 29884911 Ref: Verbascoside attenuates Rac-1 and HIF-1alpha signaling cascade in colorectal cancer cells. PMID: 29886834 Ref: MicroRNA-142-3p Promotes Cellular Invasion of Colorectal Cancer Cells by Activation of RAC1. PMID: 30064309 |