Primary Site >> Colorectal Cancer

Gene >> PTPN6

  • 2003
  • 2009
  • 2010
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  • 2017
  • 2018
Ref: The function of the protein tyrosine phosphatase SHP-1 in cancer.
PMID: 12657462
Ref: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
PMID: 20196786
Ref: Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents.
PMID: 20421638
Ref: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.
PMID: 21520296
Ref: Epithelial-Specific SHP1-P2 Methylation - a Novel Universal Tumor Marker for Detection of Colorectal Cancer Lymph Node Metastasis.
PMID: 27644671
Ref: The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3.
PMID: 28160571
Ref: RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer.
PMID: 29288235
Ref: Inflammatory genes are novel prognostic biomarkers for colorectal cancer.
PMID: 29693170