Primary Site >> Stomach Cancer
Gene >> PTPN11
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Increased expression and phosphorylation of sh-ptp2 (syp) in human gastric carcinomas. PMID: 21597824 |
Ref: Helicobacter pylori CagA--a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins. PMID: 12650772 |
Ref: Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. PMID: 14699500 |
Ref: Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. PMID: 15882975 |
Ref: Association between serum pepsinogens and polymorphismof PTPN11 encoding SHP-2 among Helicobacter pylori seropositive Japanese. PMID: 16032704 Ref: FGF signaling network in the gastrointestinal tract (review). PMID: 16773196 Ref: Genetic factors involved in the development of Helicobacter pylori-related gastric cancer. PMID: 16879717 Ref: Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy. PMID: 17211494 Ref: Significant association between PTPN11 polymorphism and gastric atrophy among Japanese Brazilians. PMID: 17235629 |
Ref: Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. PMID: 17568183 |
Ref: Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese. PMID: 19589142 Ref: Cytokine signalling via gp130 in gastric cancer. PMID: 19665497 Ref: Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study. PMID: 19822020 |
Ref: Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. PMID: 20348091 Ref: Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. PMID: 21160888 |
Ref: Potentiation of Helicobacter pylori CagA protein virulence through homodimerization. PMID: 21813645 |
Ref: Regulation of SHP2 by PTEN/AKT/GSK-3beta signaling facilitates IFN-gamma resistance in hyperproliferating gastric cancer. PMID: 22325465 Ref: Genetic susceptibility on CagA-interacting molecules and gene-environment interaction with phytoestrogens: a putative risk factor for gastric cancer. PMID: 22383989 Ref: Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population. PMID: 22788847 Ref: [H. pylori oncoprotein CagA and gastric cancer]. PMID: 23198548 Ref: Expression and clinical significance of SHP2 in gastric cancer. PMID: 23321164 |
Ref: Increased expression of tyrosine phosphatase SHP-2 in Helicobacter pylori-infected gastric cancer. PMID: 23382639 |
Ref: Host genetic factors respond to pathogenic step-specific virulence factors of Helicobacter pylori in gastric carcinogenesis. PMID: 24076409 Ref: Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1. PMID: 24354359 Ref: Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer. PMID: 24439672 |
Ref: Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. PMID: 24510342 Ref: Functions of Shp2 in cancer. PMID: 26088100 Ref: SNP interactions of Helicobacter pylori-related host genes PGC, PTPN11, IL1B, and TLR4 in susceptibility to gastric carcinogenesis. PMID: 26158864 Ref: Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis. PMID: 26507409 |
Ref: Rare Helicobacter pylori Infection May Explain Low Stomach Cancer Incidence: Ecological Observations in Bali, Indonesia. PMID: 27039823 Ref: Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus. PMID: 27572445 Ref: Chemotherapy Effectiveness and Prognosis of Gastric Cancer Influenced by PTPN11 Polymorphisms. PMID: 27614952 |
Ref: Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. PMID: 28930683 |
Ref: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. PMID: 29808010 Ref: Intramolecular energies of the cytotoxic protein CagA of Helicobacter pylori as a possible descriptor of strains' pathogenicity level. PMID: 29864542 Ref: Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate. PMID: 30374120 |