Primary Site >> Colorectal Cancer
Gene >> PTPN11
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association. PMID: 7478513 |
Ref: NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs. PMID: 15240129 |
Ref: Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2. PMID: 16920701 |
Ref: SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. PMID: 18064648 Ref: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. PMID: 18253061 |
Ref: Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. PMID: 20133777 Ref: Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation. PMID: 20671117 |
Ref: SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer. PMID: 21528083 |
Ref: Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma. PMID: 24173294 Ref: Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer. PMID: 24439672 Ref: Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling. PMID: 24651526 |
Ref: YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells. PMID: 26269757 Ref: PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs. PMID: 26365186 |
Ref: SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development. PMID: 27582544 |
Ref: T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. PMID: 27935860 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Understanding and Resetting Radiation Sensitivity in Rectal Cancer. PMID: 28742699 Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. PMID: 29110225 Ref: SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer. PMID: 29242509 |
Ref: The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/beta-catenin signaling pathway. PMID: 29323748 Ref: BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines. PMID: 29326440 Ref: Racial Disparities in the Molecular Landscape of Cancer. PMID: 29599344 Ref: Inflammatory genes are novel prognostic biomarkers for colorectal cancer. PMID: 29693170 Ref: SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo. PMID: 29808006 Ref: Clinical significance and biological function of WD repeat domain 54 as an oncogene in colorectal cancer. PMID: 29987896 Ref: Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. PMID: 30107178 |