Primary Site >> Colorectal Cancer

Gene >> PTPN1

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Ref: Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket.
PMID: 15611135
 Ref: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas.
PMID: 17143621
Ref: PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.
PMID: 17974954
 Ref: Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi.
PMID: 18183590
 Ref: Actinomycetes for marine drug discovery isolated from mangrove soils and plants in China.
PMID: 19370169
 Ref: Woodylides A-C, new cytotoxic linear polyketides from the South China Sea sponge Plakortis simplex.
PMID: 22822354
 Ref: MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer.
PMID: 23280316
Ref: Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells.
PMID: 23867504
 Ref: Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis.
PMID: 23990346
Ref: pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).
PMID: 24465712
 Ref: PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
PMID: 25617799
 Ref: Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome.
PMID: 26942883
Ref: Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma.
PMID: 27752061
Ref: Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.
PMID: 27855221