Primary Site >> Liver Cancer
Gene >> PTK2
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Ref: Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. PMID: 8930401 |
Ref: Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. PMID: 9142389 |
Ref: [TGF-beta 1 rapidly reduced hepatocarcinoma cells adhesion on to fibronectin and stimulated FAK dephosphorylation]. PMID: 12549072 |
Ref: Proteolysis of integrin alpha5 and beta1 subunits involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. PMID: 11369141 Ref: [Influence of focal adhesion kinase (FAK) on the biological behaviors of human hepatocellular carcinoma cells]. PMID: 11783016 Ref: Role of FAK in TNF-alpha/Cycloheximide-induced Apoptosis of SMMC-7721 Cells. PMID: 12053189 |
Ref: Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance. PMID: 12174366 |
Ref: [The effects of PTEN gene on migration and FAK phosphorylation of SMMC-7721 human hepatocarcinoma cell line]. PMID: 12545224 Ref: PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas. PMID: 14578863 |
Ref: Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. PMID: 15102689 Ref: Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH. PMID: 15133472 Ref: Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis. PMID: 15208664 Ref: Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. PMID: 15246215 Ref: Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines. PMID: 15532706 |
Ref: Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. PMID: 16007195 Ref: PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo. PMID: 16082187 Ref: Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis. PMID: 16094707 Ref: Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis. PMID: 16425425 |
Ref: Epigallocatechin gallate reduces hypoxia-induced apoptosis in human hepatoma cells. PMID: 16445947 |
Ref: siRNA targeted against HAb18G/CD147 inhibits MMP-2 secretion, actin and FAK expression in hepatocellular carcinoma cell line via ERK1/2 pathway. PMID: 16815629 Ref: DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. PMID: 17292327 Ref: The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence. PMID: 17551499 Ref: [Focal adhesion kinase mRNA overexpression in hepatocellular carcinoma HCC) and correlation thereof with prognosis of HCC]. PMID: 17686260 Ref: Crude extracts of Euchresta formosana radix inhibit invasion and migration of human hepatocellular carcinoma cells. PMID: 17695528 Ref: A proteomics analysis of cell signaling alterations in colorectal cancer. PMID: 17848589 Ref: [The role of FAK expression inhibition by RNA interference on liver cancer cells]. PMID: 18241574 |
Ref: Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. PMID: 17486587 Ref: Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway. PMID: 18444244 Ref: ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. PMID: 18651980 Ref: Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells. PMID: 18847500 Ref: MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway. PMID: 18948272 |
Ref: Overexpression and significance of focal adhesion kinase in hepatocellular carcinoma and its relationship with HBV infection. PMID: 19021002 Ref: Enhanced expression of Hab18g/CD147 and activation of integrin pathway in HCC cells under 3-D co-culture conditions. PMID: 19059491 Ref: Morphological changes and molecular expressions of hepatocellular carcinoma cells in three-dimensional culture model. PMID: 19615356 Ref: Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. PMID: 19824075 |
Ref: Grp78 promotes the invasion of hepatocellular carcinoma. PMID: 20082722 Ref: FAK is involved in invasion and metastasis of hepatocellular carcinoma. PMID: 20180147 Ref: Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. PMID: 20305651 Ref: MicroRNA-151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma. PMID: 20812359 Ref: Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma. PMID: 20890897 |
Ref: Kinase activation profile associated with TGF-beta-dependent migration of HCC cells: a preclinical study. PMID: 20844878 Ref: [Relative analysis of OPN and its related signal molecules in hepatocellular carcinoma]. PMID: 21272459 Ref: Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition. PMID: 21533080 Ref: HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. PMID: 21809360 Ref: [RNA interference targeting focal adhesion kinase inhibited the growth of human hepatocellular carcinoma sk-hep-1]. PMID: 21866625 Ref: Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update. PMID: 21997759 |
Ref: Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells. PMID: 22546345 Ref: CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma. PMID: 22595757 Ref: Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro. PMID: 22633845 Ref: Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma. PMID: 22897481 Ref: Focal adhesion kinase (FAK) mediates the induction of pro-oncogenic and fibrogenic phenotypes in hepatitis C virus (HCV)-infected cells. PMID: 22937161 Ref: Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway. PMID: 22971748 |
Ref: Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer. PMID: 22948179 Ref: Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma. PMID: 23258480 Ref: BTB/POZ domain-containing protein 7: epithelial-mesenchymal transition promoter and prognostic biomarker of hepatocellular carcinoma. PMID: 23325674 Ref: Prostaglandin E(2) receptor EP1-mediated phosphorylation of focal adhesion kinase enhances cell adhesion and migration in hepatocellular carcinoma cells. PMID: 23525457 Ref: FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo. PMID: 23544173 Ref: The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells. PMID: 23545258 Ref: Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells. PMID: 23721490 Ref: Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro. PMID: 24141568 |
Ref: Downregulation of JWA promotes tumor invasion and predicts poor prognosis in human hepatocellular carcinoma. PMID: 23169062 Ref: Activated hepatic stellate cells promote hepatocellular carcinoma cell migration and invasion via the activation of FAK-MMP9 signaling. PMID: 24284889 Ref: Adeno-associated virus-mediated expression of recombinant CBD-HepII polypeptide of human fibronectin inhibits metastasis of breast cancer. PMID: 24288120 Ref: CD68(+)HLA-DR(+) M1-like macrophages promote motility of HCC cells via NF-kappaB/FAK pathway. PMID: 24333724 Ref: Role of overexpression of MACC1 and/or FAK in predicting prognosis of hepatocellular carcinoma after liver transplantation. PMID: 24516351 Ref: A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma. PMID: 24789676 Ref: Targeting EGFL7 expression through RNA interference suppresses renal cell carcinoma growth by inhibiting angiogenesis. PMID: 24815445 Ref: Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways. PMID: 24962955 Ref: Full-length soluble CD147 promotes MMP-2 expression and is a potential serological marker in detection of hepatocellular carcinoma. PMID: 24996644 Ref: Association of CD98, integrin beta1, integrin beta3 and Fak with the progression and liver metastases of colorectal cancer. PMID: 25041835 Ref: Downregulation of Notch1 inhibits the invasion of human hepatocellular carcinoma HepG2 and MHCC97H cells through the regulation of PTEN and FAK. PMID: 25110169 Ref: Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PMID: 25170871 Ref: 11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways. PMID: 25222667 Ref: Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PMID: 25268648 Ref: Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation. PMID: 25273699 |
Ref: Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways. PMID: 23949904 Ref: FAK is required for c-Met/beta-catenin-driven hepatocarcinogenesis. PMID: 25163657 Ref: A chimeric antibody targeting CD147 inhibits hepatocellular carcinoma cell motility via FAK-PI3K-Akt-Girdin signaling pathway. PMID: 25424030 Ref: HAb18G/CD147 promotes radioresistance in hepatocellular carcinoma cells: a potential role for integrin beta1 signaling. PMID: 25534361 Ref: Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells. PMID: 25596737 Ref: The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1. PMID: 25762622 Ref: Transient knockdown-mediated deficiency in plectin alters hepatocellular motility in association with activated FAK and Rac1-GTPase. PMID: 25774093 Ref: The effects of focal adhesion kinase on the motility, proliferation and apoptosis of Caco2 and SMMC-7721 cells. PMID: 25790781 Ref: The role of TGFBI (betaig-H3) in gastrointestinal tract tumorigenesis. PMID: 25889002 Ref: Antcin K, an Active Triterpenoid from the Fruiting Bodies of Basswood-Cultivated Antrodia cinnamomea, Inhibits Metastasis via Suppression of Integrin-Mediated Adhesion, Migration, and Invasion in Human Hepatoma Cells. PMID: 25911944 Ref: Thyroid hormone-mediated regulation of lipocalin 2 through the Met/FAK pathway in liver cancer. PMID: 25940797 Ref: The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated alpha2M. PMID: 25958313 Ref: Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway. PMID: 25978354 Ref: 3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling. PMID: 26068982 Ref: Gene therapy targeting hepatocellular carcinoma by a dual-regulated oncolytic adenovirus harboring the focal adhesion kinase shRNA. PMID: 26081241 Ref: MRC-5 fibroblast-conditioned medium influences multiple pathways regulating invasion, migration, proliferation, and apoptosis in hepatocellular carcinoma. PMID: 26198300 Ref: CD147 reinforces [Ca2+]i oscillations and promotes oncogenic progression in hepatocellular carcinoma. PMID: 26498680 Ref: Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1. PMID: 26621448 |
Ref: Overexpression of Rab5a promotes hepatocellular carcinoma cell proliferation and invasion via FAK signaling pathway. PMID: 26443539 Ref: A20 inhibits the motility of HCC cells induced by TNF-alpha. PMID: 26909601 Ref: Liver fatty acid-binding protein (L-FABP) promotes cellular angiogenesis and migration in hepatocellular carcinoma. PMID: 26919097 Ref: MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma. PMID: 26944318 Ref: An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway. PMID: 26996299 Ref: Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling. PMID: 27100895 Ref: FAK Kinase Activity Is Required for the Progression of c-MET/beta-Catenin-Driven Hepataocellular Carcinoma. PMID: 27142958 Ref: FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling. PMID: 27216177 Ref: Effect of saracatinib on pulmonary metastases from hepatocellular carcinoma. PMID: 27460949 Ref: Downregulation of SLC5A8 inhibits hepatocellular carcinoma progression through regulation of Wnt/beta-catenin signaling. PMID: 27465549 Ref: Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis. PMID: 27637100 Ref: CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation. PMID: 27638856 Ref: Hepatic stellate cells induce hepatocellular carcinoma cell resistance to sorafenib through the laminin-332/alpha3 integrin axis recovery of focal adhesion kinase ubiquitination. PMID: 27639064 |
Ref: Silencing IGF-II impairs C-myc and N-ras expressions of SMMC-7721 cells via suppressing FAK/PI3K/Akt signaling pathway. PMID: 27768959 Ref: Immediate early response protein 2 regulates hepatocellular carcinoma cell adhesion and motility via integrin beta1-mediated signaling pathway. PMID: 27840969 Ref: NEDD9 may regulate hepatocellular carcinoma cell metastasis by promoting epithelial-mesenchymal-transition and stemness via repressing Smad7. PMID: 27974675 Ref: Overexpression of RAS-Association Domain Family 6 (RASSF6) Inhibits Proliferation and Tumorigenesis in Hepatocellular Carcinoma Cells. PMID: 27983932 Ref: Substrate stiffness promotes latent TGF-beta1 activation in hepatocellular carcinoma. PMID: 28025149 Ref: Knockdown of Rap2B Inhibits the Proliferation and Invasion in Hepatocellular Carcinoma Cells. PMID: 28081729 Ref: The Effect of a Histone Deacetylase Inhibitor (AR-42) on Canine Prostate Cancer Growth and Metastasis. PMID: 28181686 Ref: Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity. PMID: 28255353 Ref: Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2. PMID: 28338656 Ref: Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles. PMID: 28339069 Ref: Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signalling pathway. PMID: 28395993 Ref: MiR-425-5p promotes invasion and metastasis of hepatocellular carcinoma cells through SCAI-mediated dysregulation of multiple signaling pathways. PMID: 28423650 Ref: Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling. PMID: 28433634 Ref: SRPX2, an independent prognostic marker, promotes cell migration and invasion in hepatocellular carcinoma. PMID: 28654796 Ref: Quantitative proteomics reveal the anti-tumour mechanism of the carbohydrate recognition domain of Galectin-3 in Hepatocellular carcinoma. PMID: 28701735 Ref: ANGPTL1 Interacts with Integrin alpha1beta1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling. PMID: 28904065 Ref: OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma. PMID: 28911005 Ref: Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation. PMID: 28912543 Ref: Connexin 32 affects doxorubicin resistance in hepatocellular carcinoma cells mediated by Src/FAK signaling pathway. PMID: 28968929 Ref: Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas. PMID: 29038587 Ref: Cross-talk mechanism between endothelial cells and hepatocellular carcinoma cells via growth factors and integrin pathway promotes tumor angiogenesis and cell migration. PMID: 29050226 Ref: FAK, Src and p-Paxillin expression is decreased in liver metastasis of colorectal carcinoma patients. PMID: 29135089 Ref: Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3. PMID: 29151962 Ref: Collagen I promotes hepatocellular carcinoma cell proliferation by regulating integrin beta1/FAK signaling pathway in nonalcoholic fatty liver. PMID: 29221151 |
Ref: Fluid shear stress regulates HepG2 cell migration though time-dependent integrin signaling cascade. PMID: 28636424 Ref: Myofibrillogenesis regulator 1 (MR-1): a potential therapeutic target for cancer and PNKD. PMID: 29103325 Ref: Mitochondrial fission promotes cell migration by Ca(2+) /CaMKII/ERK/FAK pathway in hepatocellular carcinoma. PMID: 29210177 Ref: beta1 integrin-mediated multicellular resistance in hepatocellular carcinoma through activation of the FAK/Akt pathway. PMID: 29332411 Ref: Herbal formula YGJDSJ inhibits anchorage-independent growth and induces anoikis in hepatocellular carcinoma Bel-7402 cells. PMID: 29338725 Ref: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway. PMID: 29454618 Ref: CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma. PMID: 29506532 Ref: Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway. PMID: 29678550 Ref: CD31 regulates metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway. PMID: 29746931 Ref: miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway. PMID: 29864952 Ref: Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a beta1-integrin-FAK-YAP1/TAZ signaling pathway. PMID: 29872721 Ref: Integrin alpha9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling. PMID: 29951557 Ref: ADAM17 promotes cell migration and invasion through the integrin beta1 pathway in hepatocellular carcinoma. PMID: 29966664 Ref: LncRNA DBH-AS1 facilitates the tumorigenesis of hepatocellular carcinoma by targeting miR-138 via FAK/Src/ERK pathway. PMID: 30142544 Ref: Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti-cancer effect of dasatinib in hepatocellular carcinoma. PMID: 30292831 Ref: Focal adhesion kinase activation limits efficacy of Dasatinib in c-Myc driven hepatocellular carcinoma. PMID: 30370649 |