Primary Site >> Colorectal Cancer
Gene >> PTK2
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Ref: Correlations between the expression, phosphotyrosine content and enzymatic activity of focal adhesion kinase, pp125FAK, in tumor and nontransformed cells. PMID: 8937737 |
Ref: Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). PMID: 8999970 Ref: A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. PMID: 9018114 Ref: Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. PMID: 9142389 |
Ref: De novo expression of the alpha5beta1-fibronectin receptor in HT29 colon-cancer cells reduces activity of C-SRC. Increase of C-SRC activity by attachment on fibronectin. PMID: 9533767 Ref: Acquisition of cell adhesion and induction of focal adhesion kinase of human colon cancer Colo 201 cells by retinoic acid-induced differentiation. PMID: 9566310 Ref: Analysis of signaling protein kinases in human colon or colorectal carcinomas. PMID: 9690379 Ref: Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A. PMID: 9872566 |
Ref: Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. PMID: 10523844 Ref: Role of the cytoskeleton in adhesion stabilization of human colorectal carcinoma cells to extracellular matrix components under dynamic conditions of laminar flow. PMID: 10919716 |
Ref: Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways. PMID: 10741720 Ref: [Effect of laminin antisense RNA on the expression of five intracellular proteins stimulated by transforming growth factor beta(1)]. PMID: 10751536 Ref: Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. PMID: 10873094 Ref: Time-dependent dephosphorylation through serine/threonine phosphatases is required for stable adhesion of highly and poorly metastatic HT-29 colon carcinoma cell lines to collagen. PMID: 10953284 |
Ref: (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. PMID: 11196148 Ref: The protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cells. PMID: 11494115 |
Ref: CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase. PMID: 11774285 Ref: PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow. PMID: 11857088 Ref: Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells. PMID: 11980666 Ref: Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance. PMID: 12174366 Ref: Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice. PMID: 12207005 Ref: Src protein kinase pp60c-src influences adhesion stabilization of HT-29 colon carcinoma cells to extracellular matrix components under dynamic conditions of laminar flow. PMID: 12416028 |
Ref: Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. PMID: 12538472 Ref: Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tu PMID: 12748308 Ref: Expression of GRP and its receptor in well-differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosines 397 and 407. PMID: 12871985 Ref: Absence of adhesion triggers differential FAK and SAPKp38 signals in SW620 human colon cancer cells that may inhibit adhesiveness and lead to cell death. PMID: 12876384 Ref: Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. PMID: 12939401 Ref: Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients. PMID: 12943621 Ref: Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo. PMID: 14528320 |
Ref: Rapid tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130Cas by gastrin in human colon cancer cells. PMID: 14667936 Ref: Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. PMID: 14699482 Ref: Csk defines the ability of integrin-mediated cell adhesion and migration in human colon cancer cells: implication for a potential role in cancer metastasis. PMID: 14712234 Ref: Phosphorylation of focal adhesion kinase tyrosine 397 critically mediates gastrin-releasing peptide's morphogenic properties. PMID: 14978737 Ref: Transforming growth factor beta regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells. PMID: 15133493 Ref: Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion. PMID: 15302590 Ref: Focal adhesion kinase in netrin-1 signaling. PMID: 15494733 |
Ref: Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. PMID: 15735019 Ref: DNA copy number changes at 8q11-24 in metastasized colorectal cancer. PMID: 15750208 Ref: Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. PMID: 15855171 Ref: Transient upregulation of GRP and its receptor critically regulate colon cancer cell motility during remodeling. PMID: 15890713 Ref: The role of the cytoskeleton in differentially regulating pressure-mediated effects on malignant colonocyte focal adhesion signaling and cell adhesion. PMID: 15917311 Ref: [Effect of gastrin on invasiveness of human colon cancer cells]. PMID: 15949418 Ref: Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells. PMID: 15951156 Ref: Butyrate regulates the expression of c-Src and focal adhesion kinase and inhibits cell invasion of human colon cancer cells. PMID: 16001424 Ref: [A study of gastrin-focal adhesion kinase signal pathway in human colon cancer cells]. PMID: 16008856 Ref: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. PMID: 16052481 Ref: Focal adhesion kinase regulates syndecan-2-mediated tumorigenic activity of HT1080 fibrosarcoma cells. PMID: 16267014 |
Ref: Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. PMID: 16241905 Ref: Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas. PMID: 16353145 Ref: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. PMID: 16371650 Ref: Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway. PMID: 16461767 Ref: EGF receptor-related protein (ERRP) inhibits invasion of colon cancer cells and tubule formation by endothelial cells in vitro. PMID: 16619503 Ref: Extracellular pressure stimulates tumor cell adhesion in vitro by paxillin activation. PMID: 16855384 Ref: Focal adhesion kinase protein levels in gut epithelial motility. PMID: 16899713 Ref: Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2. PMID: 16920701 Ref: Enhanced expression of cholecystokinin-2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase. PMID: 16998832 Ref: Pressure stimulates breast cancer cell adhesion independently of cell cycle and apoptosis regulatory protein (CARP)-1 regulation of focal adhesion kinase. PMID: 17071197 |
Ref: Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase. PMID: 16920698 Ref: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. PMID: 17030349 Ref: A simple method for the routine detection of somatic quantitative genetic alterations in colorectal cancer. PMID: 17258723 Ref: FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. PMID: 17317726 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 Ref: Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase. PMID: 17496330 Ref: Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices. PMID: 17706640 Ref: Focal adhesion kinase and p53 signaling in cancer cells. PMID: 17725966 Ref: [Molecular mechanism of gastrin increasing colon cancer cells' invasion]. PMID: 17825155 Ref: A proteomics analysis of cell signaling alterations in colorectal cancer. PMID: 17848589 Ref: [Effects of hFRNK on E-cadherin/beta-catenin in colon cancer cells in vitro]. PMID: 17892129 Ref: Alpha-actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction. PMID: 17898132 Ref: Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion. PMID: 17982677 |
Ref: Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines. PMID: 17904248 Ref: p53 regulates FAK expression in human tumor cells. PMID: 17999388 Ref: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. PMID: 18320073 Ref: Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1. PMID: 18392556 Ref: ANTI-ADHESION evolves to a promising therapeutic concept in oncology. PMID: 18393855 Ref: Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation. PMID: 18556171 Ref: Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells. PMID: 18558091 Ref: Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly. PMID: 18562041 Ref: Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice. PMID: 18704196 Ref: Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells. PMID: 18805444 Ref: Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. PMID: 18922892 Ref: Fibronectin promotes invasiveness and focal adhesion kinase tyrosine phosphorylation of human colon cancer cell. PMID: 19260479 |
Ref: Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. PMID: 19138410 Ref: Focal adhesion kinase and cancer. PMID: 19224453 Ref: NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells. PMID: 19234748 Ref: Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. PMID: 19276381 Ref: Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells. PMID: 19290007 Ref: Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance. PMID: 19500106 Ref: XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. PMID: 19543321 Ref: 3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226. PMID: 19729215 Ref: [Effects of FAK expression level on proliferation and motility of colorectal carcinoma cells]. PMID: 19737461 Ref: Focal adhesion kinase functions as an akt downstream target in migration of colorectal cancer cells. PMID: 19956390 |
Ref: The effect of focal adhesion kinase gene silencing on 5-fluorouracil chemosensitivity involves an Akt/NF-kappaB signaling pathway in colorectal carcinomas. PMID: 19904749 Ref: TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways. PMID: 20118200 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. PMID: 20136087 Ref: Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation. PMID: 20347121 Ref: Focal adhesion kinase and p53 signal transduction pathways in cancer. PMID: 20515733 Ref: Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells. PMID: 20678483 Ref: Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer. PMID: 20682712 Ref: Getting one's Fak straight. PMID: 20708578 Ref: Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. PMID: 20708588 Ref: P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. PMID: 20811717 Ref: Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells. PMID: 20863062 Ref: Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. PMID: 21152443 Ref: RNA interference-mediated silencing of focal adhesion kinase inhibits growth of human colon carcinoma xenograft in nude mice. PMID: 21179944 |
Ref: Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. PMID: 21209368 Ref: p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. PMID: 21224360 Ref: Translational research in pancreatic cancer. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011. PMID: 21386635 Ref: Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells. PMID: 21467134 Ref: Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis. PMID: 21478904 Ref: FAK and WNT signaling: the meeting of two pathways in cancer and development. PMID: 21707509 Ref: ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. PMID: 21768110 Ref: alphav integrin processing interferes with the cross-talk between alphavbeta5/beta6 and alpha2beta1 integrins. PMID: 21787362 Ref: Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach. PMID: 21849056 Ref: Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to alpha5beta1 integrin and suppresses FAK/ERK/NF-kappaB signaling. PMID: 21963225 Ref: Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells. PMID: 21968138 Ref: Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734. PMID: 21994943 Ref: Deoxyribose protects against rapamycin-induced cytotoxicity in colorectal cancer cells in vitro. PMID: 22132975 |
Ref: Recombinant canstatin inhibits angiopoietin-1-induced angiogenesis and lymphangiogenesis. PMID: 21823121 Ref: MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression. PMID: 21860426 Ref: Thrombin-dependent modulation of beta1-integrin-mediated signaling up-regulates prolidase and HIF-1alpha through p-FAK in colorectal cancer cells. PMID: 21993963 Ref: Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. PMID: 22266115 Ref: Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approach. PMID: 22298312 Ref: A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonog PMID: 22402131 Ref: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. PMID: 22685302 Ref: Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer. PMID: 22705303 Ref: Expression of cortactin and focal adhesion kinase in colorectal adenocarcinoma: correlation with clinicopathologic parameters and their prognostic implication. PMID: 23136572 |
Ref: A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. PMID: 22292771 Ref: Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK. PMID: 22641216 Ref: FAK, CD44v6, c-Met and EGFR in colorectal cancer parameters: tumour progression, metastasis, patient survival and receptor crosstalk. PMID: 22733437 Ref: FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes. PMID: 22934709 Ref: Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. PMID: 23027128 Ref: Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules. PMID: 23232649 Ref: Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells. PMID: 23316499 Ref: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. PMID: 23333577 Ref: Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. PMID: 23485528 Ref: Vascular endothelial growth factor receptors 1,3 and caveolin-1 are implicated in colorectal cancer aggressiveness and prognosis--correlations with epidermal growth factor receptor, CD44v6, focal adhesion kinase, and c-Met. PMID: 23580180 Ref: Syndecan-2 is upregulated in colorectal cancer cells through interactions with extracellular matrix produced by stromal fibroblasts. PMID: 23705906 Ref: Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. PMID: 23792569 Ref: Fibronectin extra domain A (EDA) sustains CD133(+)/CD44(+) subpopulation of colorectal cancer cells. PMID: 23811539 Ref: Double targeting of Survivin and XIAP radiosensitizes 3D grown human colorectal tumor cells and decreases migration. PMID: 23830189 Ref: Sulindac modulates secreted protein expression from LIM1215 colon carcinoma cells prior to apoptosis. PMID: 23899461 Ref: Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. PMID: 23970932 Ref: [Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1]. PMID: 24054007 Ref: Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis. PMID: 24312323 |
Ref: The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK. PMID: 23390052 Ref: Dysregulation of microRNA-34a expression in colorectal cancer inhibits the phosphorylation of FAK via VEGF. PMID: 24370784 Ref: Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex. PMID: 24452144 Ref: Role of overexpression of MACC1 and/or FAK in predicting prognosis of hepatocellular carcinoma after liver transplantation. PMID: 24516351 Ref: Targeting EGFL7 expression through RNA interference suppresses renal cell carcinoma growth by inhibiting angiogenesis. PMID: 24815445 Ref: Radiation sensitization of tumor cells induced by shear stress: the roles of integrins and FAK. PMID: 24946134 Ref: Association of CD98, integrin beta1, integrin beta3 and Fak with the progression and liver metastases of colorectal cancer. PMID: 25041835 Ref: Nuclear expression of phosphorylated focal adhesion kinase is associated with poor prognosis in human colorectal cancer. PMID: 25075018 Ref: Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways. PMID: 25111127 Ref: Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway. PMID: 25113506 Ref: NFAT5-mediated expression of S100A4 contributes to proliferation and migration of renal carcinoma cells. PMID: 25152734 Ref: Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor. PMID: 25175595 Ref: Src activity is modulated by oxaliplatin and correlates with outcomes after hepatectomy for metastatic colorectal cancer. PMID: 25208577 |
Ref: Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling. PMID: 24497447 Ref: Progastrin a new pro-angiogenic factor in colorectal cancer. PMID: 25109333 Ref: A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. PMID: 25351103 Ref: Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT-29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth. PMID: 25403643 Ref: Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling. PMID: 25543087 Ref: Defective apical extrusion signaling contributes to aggressive tumor hallmarks. PMID: 25621765 Ref: Modulation of intracellular calcium levels by calcium lactate affects colon cancer cell motility through calcium-dependent calpain. PMID: 25629974 Ref: Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling. PMID: 25636878 Ref: Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. PMID: 25644809 Ref: Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15. PMID: 25656374 Ref: The effects of focal adhesion kinase on the motility, proliferation and apoptosis of Caco2 and SMMC-7721 cells. PMID: 25790781 Ref: Human enhancer of filamentation 1-induced colorectal cancer cell migration: Role of serine phosphorylation and interaction with the breast cancer anti-estrogen resistance 3 protein. PMID: 25817040 Ref: Inhibitory effects of proton beam irradiation on integrin expression and signaling pathway in human colon carcinoma HT29 cells. PMID: 25845382 Ref: Colorectal Cancer Metastases Settle in the Hepatic Microenvironment Through alpha5beta1 Integrin. PMID: 25857463 Ref: IL13 Receptor alpha2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis. PMID: 25896327 Ref: Gastrin-stimulated Galpha13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells. PMID: 25922072 Ref: Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-beta/Smad2/3 signaling. PMID: 25934251 Ref: Widdrol, a sesquiterpene isolated from Juniperus chinensis, inhibits angiogenesis by targeting vascular endothelial growth factor receptor 2 signaling. PMID: 26133679 Ref: FAK/PYK2 promotes the Wnt/beta-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3beta. PMID: 26274564 Ref: Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies. PMID: 27595061 |
Ref: DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53. PMID: 26494468 Ref: MicroRNA7 suppresses human colon cancer invasion and proliferation by targeting the expression of focal adhesion kinase. PMID: 26648422 Ref: Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cellextracellular matrix adhesion for migration. PMID: 26891990 Ref: Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling. PMID: 26895766 Ref: Inhibition of adhesion, migration and of alpha5beta1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. PMID: 26961176 Ref: A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors. PMID: 27025608 Ref: Claudin-7 indirectly regulates the integrin/FAK signaling pathway in human colon cancer tissue. PMID: 27121327 Ref: Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling. PMID: 27127177 Ref: Focal adhesion kinase: predictor of tumour response and risk factor for recurrence after neoadjuvant chemoradiation in rectal cancer. PMID: 27171907 Ref: Activation of focal adhesion kinase through an interaction with beta4 integrin contributes to tumorigenicity of colon cancer. PMID: 27178753 Ref: Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and beta-catenin signaling pathways. PMID: 27422337 Ref: Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development. PMID: 27460083 Ref: DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling. PMID: 27517319 Ref: TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway. PMID: 27644693 Ref: Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. PMID: 27664007 Ref: Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation. PMID: 27834811 Ref: CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer. PMID: 27942222 |
Ref: Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer. PMID: 27401248 Ref: Synergistically Anti-metastatic Effect of 5-Flourouracil on Colorectal Cancer Cells via Calcium-mediated Focal Adhesion Kinase Proteolysis. PMID: 28011480 Ref: Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo. PMID: 28138708 Ref: MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway. PMID: 28186967 Ref: Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity. PMID: 28255353 Ref: Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer. PMID: 28280091 Ref: RSK activation via ERK modulates human colon cancer cells response to PTHrP. PMID: 28385776 Ref: SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells. PMID: 28405684 Ref: The nuclear orphan receptor NR4A1 regulates beta1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. PMID: 28418095 Ref: A crosstalk between muscarinic and CRF2 receptors regulates cellular adhesion properties of human colon cancer cells. PMID: 28432022 Ref: Enhancing 5-Fluorouracil Efficacy in a Primary Colorectal Cancer by Long-lasting Calcium Supplementation. PMID: 28551633 Ref: The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis. PMID: 28562687 Ref: TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways. PMID: 28624785 Ref: Cellular prion protein (PrP(C)) in the development of Merlin-deficient tumours. PMID: 28692055 Ref: TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching. PMID: 28701345 Ref: Filamin A upregulation correlates with Snail-induced epithelial to mesenchymal transition (EMT) and cell adhesion but its inhibition increases the migration of colon adenocarcinoma HT29 cells. PMID: 28778796 Ref: The C-terminal region of the focal adhesion kinase F1 domain binds Akt1 and inhibits pressure-induced cell adhesion. PMID: 28820394 Ref: Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cgamma-mediated FAK/ERK signaling pathway in colon cancer. PMID: 28821612 Ref: Sushi repeat-containing protein X-linked 2 promotes angiogenesis through the urokinase-type plasminogen activator receptor dependent integrin alphavbeta3/focal adhesion kinase pathways. PMID: 28867754 Ref: Resveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules. PMID: 28953264 Ref: Induction of Anoikis in Human Colorectal Cancer Cells by Fucoxanthinol. PMID: 28990814 Ref: Identification of zinc finger protein of the cerebellum 5 as a survival factor of prostate and colorectal cancer cells. PMID: 29024195 Ref: Phosphoinositide-specific phospholipase Cgamma1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells. PMID: 29066806 Ref: Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model. PMID: 29091939 Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. PMID: 29110225 Ref: FAK, Src and p-Paxillin expression is decreased in liver metastasis of colorectal carcinoma patients. PMID: 29135089 Ref: Inhibition of pressure-activated cancer cell adhesion by FAK-derived peptides. PMID: 29228673 |
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