Primary Site >> Colorectal Cancer

Gene >> PTGES

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Ref: Regulation of cyclooxygenase-2 pathway by HER2 receptor.
PMID: 9927187
 Ref: Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.
PMID: 11751489
 Ref: Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.
PMID: 12626523
Ref: Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents.
PMID: 12818365
Ref: Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.
PMID: 12835322
 Ref: 15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.
PMID: 16495511
 Ref: 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice.
PMID: 18058808
Ref: Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
PMID: 18451151
Ref: GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.
PMID: 18479189
Ref: Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.
PMID: 18485889
Ref: [Role of prostaglandins in colon cancer].
PMID: 18516010
 Ref: Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer.
PMID: 19035518
Ref: Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients.
PMID: 19412621
 Ref: Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors.
PMID: 19820419
Ref: Receptor and enzyme expression for prostanoid metabolism in colorectal cancer related to tumor tissue PGE2.
PMID: 20043083
Ref: mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators".
PMID: 20159031
Ref: Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.
PMID: 20635443
Ref: Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis.
PMID: 20682710
 Ref: Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis.
PMID: 20722052
Ref: Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity.
PMID: 21576350
 Ref: Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.
PMID: 21931968
Ref: Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
PMID: 21986945
 Ref: Hypoxia-inducible factor-2alpha is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer.
PMID: 23042097
 Ref: Raloxifene and antiestrogenic gonadorelin inhibits intestinal tumorigenesis by modulating immune cells and decreasing stem-like cells.
PMID: 24431404
Ref: Prostaglandin E2 produced by inducible COX-2 and mPGES-1 promoting cancer cell proliferation in vitro and in vivo.
PMID: 25139833
 Ref: Instability of a dinucleotide repeat in the 3'-untranslated region (UTR) of the microsomal prostaglandin E synthase-1 (mPGES-1) gene in microsatellite instability-high (MSI-H) colorectal carcinoma.
PMID: 25817443
Ref: Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes.
PMID: 25886460
Ref: Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment.
PMID: 26100239
Ref: Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis.
PMID: 26150361
Ref: Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression.
PMID: 26498686
 Ref: Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.
PMID: 26477319
 Ref: Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.
PMID: 27481098
Ref: Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.
PMID: 28549801
Ref: A network-based predictive gene-expression signature for adjuvant chemotherapy benefit in stage II colorectal cancer.
PMID: 29237416
 Ref: Anti-inflammatory Effects of Enhanced Recovery Programs on Early-Stage Colorectal Cancer Surgery.
PMID: 28983734
Ref: Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells.
PMID: 30041241