Primary Site >> Colorectal Cancer
Gene >> PTGER4
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Ref: [Tumor cell dissemination in bone marrow and peritoneal cavity. An immunocytochemical study of patients with stomach or colorectal carcinoma]. PMID: 8717176 |
Ref: Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis. PMID: 9504818 |
Ref: Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression. PMID: 10082276 |
Ref: Effect of prostaglandin E1 on vascular endothelial growth factor production by human macrophages and colon cancer cells. PMID: 10965822 |
Ref: Immunobead RT-PCR versus regular RT-PCR amplification of CEA mRNA in peripheral blood. PMID: 11501748 |
Ref: Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. PMID: 12837940 |
Ref: Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation. PMID: 15123663 Ref: Tissue preparation for gene expression profiling of colorectal carcinoma: three alternatives to laser microdissection with preamplification. PMID: 15192650 |
Ref: Detection of cytokeratin 20 mRNA in the peripheral blood of patients with colorectal cancer by immunomagnetic bead enrichment and real-time reverse transcriptase-polymeras chain reaction. PMID: 16048578 |
Ref: Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts. PMID: 16534415 Ref: Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence. PMID: 16540660 Ref: Roles of prostanoids in colon carcinogenesis and their potential targeting for cancer chemoprevention. PMID: 16842185 Ref: Signal transduction cross-talk during colorectal tumorigenesis. PMID: 16998321 Ref: Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism. PMID: 17018624 |
Ref: Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. PMID: 17130837 Ref: Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses. PMID: 17201907 Ref: Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts. PMID: 17332478 Ref: Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells. PMID: 17555711 Ref: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. PMID: 17631291 Ref: PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation. PMID: 17640974 Ref: Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. PMID: 17875695 |
Ref: Prostanoid receptor EP1 expression in breast cancer. PMID: 17906615 Ref: Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched. PMID: 18456845 Ref: Dendritic cell infiltration pattern along the colorectal adenoma-carcinoma sequence. PMID: 18754318 |
Ref: Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. PMID: 19558693 |
Ref: Prostaglandin E2-induced colonic secretion in patients with and without colorectal neoplasia. PMID: 20100359 Ref: EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells. PMID: 20571779 Ref: Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells. PMID: 20689756 Ref: The induction of S100p expression by the Prostaglandin E(2) (PGE(2))/EP4 receptor signaling pathway in colon cancer cells. PMID: 20890108 |
Ref: MicroRNA-101 (miR-101) post-transcriptionally regulates the expression of EP4 receptor in colon cancers. PMID: 22353936 Ref: A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma. PMID: 22551900 Ref: HT-29 human colon cancer cell proliferation is regulated by cytosolic phospholipase A(2)alpha dependent PGE(2)via both PKA and PKB pathways. PMID: 22728329 Ref: Association of polymorphisms in microRNA-binding sites and colorectal cancer in an Iranian population. PMID: 22939228 |
Ref: Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer. PMID: 23390011 Ref: [Expression and function of E prostanoid receptors in urological cancer]. PMID: 23552749 Ref: Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Galphai and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. PMID: 23973650 |
Ref: Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. PMID: 25096910 |
Ref: Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer. PMID: 25623217 Ref: Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1alpha in HCA-7 human colon cancer cells. PMID: 25692008 Ref: Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. PMID: 26261008 Ref: Cyclooxygenase-2 knockdown using retinoic acid chalcone (RAC), a promising therapeutic strategy for colon cancer. PMID: 26269760 Ref: Upregulation of C-C chemokine receptor type 7 expression by membrane-associated prostaglandin E synthase-1/prostaglandin E2 requires glycogen synthase kinase 3beta-mediated signal transduction in colon cancer cells. PMID: 26352871 Ref: Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis. PMID: 26378024 Ref: Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cell PMID: 26518053 |
Ref: The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling. PMID: 26830476 Ref: Cytotoxic and pro-oxidative effects of Imperata cylindrica aerial part ethyl acetate extract in colorectal cancer in vitro. PMID: 27064015 Ref: Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. PMID: 27548026 |
Ref: Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. PMID: 27864128 Ref: Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. PMID: 28275297 Ref: Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells. PMID: 28587064 Ref: Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. PMID: 28652251 Ref: Targeting G-protein coupled receptor-related signaling pathway in a murine xenograft model of appendiceal pseudomyxoma peritonei. PMID: 29290997 |
Ref: Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT-116 cells through down-regulation of prostaglandin E2 receptor EP4. PMID: 30269738 |