Primary Site >> Pancreatic Cancer
Gene >> PTF1A
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Ref: Combined effects of alpha-difluoromethylornithine and doxorubicin against pancreatic cancer cell lines in culture. PMID: 3106959 |
Ref: PTF1alpha/p48 transcription factor couples proliferation and differentiation in the exocrine pancreas [corrected]. PMID: 15362048 |
Ref: Characterization of Kras-mediated pancreatic tumorigenesis in zebrafish. PMID: 18413263 Ref: Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. PMID: 18549880 Ref: Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation. PMID: 18725222 |
Ref: Id3 modulates cellular localization of bHLH Ptf1-p48 protein. PMID: 20830706 Ref: Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PMID: 22164219 |
Ref: Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer. PMID: 23237571 Ref: Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors. PMID: 23349836 |
Ref: Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis. PMID: 23598351 Ref: Identification and manipulation of biliary metaplasia in pancreatic tumors. PMID: 23999170 Ref: Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms. PMID: 24067880 Ref: Multimodal molecular imaging of integrin alphavbeta3 for in vivo detection of pancreatic cancer. PMID: 24549287 Ref: PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. PMID: 25311989 Ref: The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer. PMID: 25380065 |
Ref: Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey. PMID: 25065594 Ref: Inhibition of progression of PanIN through antagonizing EGFR. PMID: 25519686 Ref: The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma. PMID: 26151762 Ref: Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. PMID: 26255562 |
Ref: Inactivation of TGFbeta receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis. PMID: 26510396 Ref: Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia. PMID: 26762195 Ref: Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver. PMID: 27506299 Ref: Downregulation of expression of mater genes SOX9, FOXA2, and GATA4 in pancreatic cancer cells stimulated with TGFbeta1 epithelial-mesenchymal transition. PMID: 27599506 Ref: Activation of WNT/beta-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61. PMID: 27889647 |
Ref: The TALE homeodomain transcription factor MEIS1 activates the pro-metastatic melanoma cell adhesion molecule Mcam to promote migration of pancreatic cancer cells. PMID: 27583552 Ref: Mutant p53 Together with TGFbeta Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer. PMID: 27637888 Ref: LSL-KrasG12D; LSL-Trp53R172H/+; Ink4flox/+; Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer. PMID: 28475592 Ref: HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer. PMID: 28697176 Ref: c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice. PMID: 28837246 Ref: Expression of master regulatory genes of embryonic development in pancreatic tumors. PMID: 28864900 Ref: Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling. PMID: 28872120 |
Ref: c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis. PMID: 28159836 Ref: Mechanistic insights into the activity of Ptf1-p48 (pancreas transcription factor 1a): probing the interactions levels of Ptf1-p48 with E2A-E47 (transcription factor E2-alpha) and ID3 (inhibitor of DNA binding 3). PMID: 28571517 Ref: Kruppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice. PMID: 29248441 Ref: Investigating the role of transcription factors of pancreas development in pancreatic cancer. PMID: 29289465 Ref: Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment. PMID: 29719936 Ref: The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis. PMID: 30010625 Ref: NMR-based metabolic profiling of urine, serum, fecal, and pancreatic tissue samples from the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer. PMID: 30016349 Ref: Solid-pseudopapillary neoplasms of the pancreas do not express major pancreatic markers in pediatric patients. PMID: 30130629 Ref: Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin. PMID: 30242282 |