Primary Site >> Liver Cancer
Gene >> PTEN
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: PTEN/MMAC1 mutations in hepatocellular carcinomas. PMID: 10340391 |
Ref: Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma. PMID: 10705874 Ref: PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas. PMID: 10760687 Ref: Hepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression. PMID: 11003625 Ref: [Mutation analysis of the tumor suppressor gene PTEN/MMAC1/TEP1 in human hepatocellular carcinoma]. PMID: 12549040 |
Ref: Gene microarray analysis reveals a novel hypoxia signal transduction pathway in human hepatocellular carcinoma cells. PMID: 11408933 |
Ref: Impact of PTEN expression on the outcome of hepatitis C virus-positive cirrhotic hepatocellular carcinoma patients: possible relationship with COX II and inducible nitric oxide synthase. PMID: 12115563 Ref: Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. PMID: 12433278 |
Ref: [The effects of PTEN gene on migration and FAK phosphorylation of SMMC-7721 human hepatocarcinoma cell line]. PMID: 12545224 Ref: [Expression of phosphatase and tensin homology deleted on chromosome ten(PTEN) and p53 protein and their significance in human hepatocellular carcinomas]. PMID: 12561434 Ref: Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma. PMID: 12660822 Ref: Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis. PMID: 12668978 Ref: The alteration of PTEN tumor suppressor expression and its association with the histopathological features of human primary hepatocellular carcinoma. PMID: 12669234 Ref: Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma. PMID: 12673720 Ref: Expression and significance of new tumor suppressor gene PTEN in primary liver cancer. PMID: 12767263 Ref: PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells. PMID: 12804776 Ref: Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival. PMID: 12827550 Ref: Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. PMID: 12839924 Ref: [PTEN expression and its significance in human primary hepatocellular carcinoma]. PMID: 12939185 |
Ref: Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver. PMID: 14713550 Ref: Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. PMID: 15132991 Ref: [Expression of PTEN, Cx43, and VEGF in hepatocellular carcinoma]. PMID: 15191666 Ref: Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. PMID: 15199412 Ref: Genetic alterations in doxorubicin-resistant hepatocellular carcinoma cells: a combined study of spectral karyotyping, positional expression profiling and candidate genes. PMID: 15492826 Ref: Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines. PMID: 15532706 |
Ref: Correlation between loss of PTEN expression and PKB/AKT phosphorylation in hepatocellular carcinoma. PMID: 15934306 Ref: Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines. PMID: 16052674 Ref: [Tumor suppressor gene PTEN and non-alcoholic steatohepatitis (NASH)]. PMID: 16101243 Ref: Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. PMID: 16214396 |
Ref: PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib. PMID: 16707461 Ref: [Hepatocyte-specific Pten deficient mice]. PMID: 16768106 Ref: PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells. PMID: 16872708 Ref: Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis. PMID: 17013836 Ref: [Anti-tumor effect and mechanism of Paeonol on the hepatocellular carcinoma cell line Bel-7404]. PMID: 17062930 Ref: [Mutations of tumor suppressor gene PTEN mutations in hepatocellular carcinoma and its implications in tumor proliferation and apoptosis]. PMID: 17069699 |
Ref: Survival and apoptosis: a dysregulated balance in liver cancer. PMID: 17311609 Ref: Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. PMID: 17318075 Ref: Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma. PMID: 17441812 Ref: Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells. PMID: 17506947 Ref: Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. PMID: 17567478 Ref: [Expression of PTEN in athymic mice with HCC treated by complex prescription of Chinese crude drug]. PMID: 17672343 Ref: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. PMID: 17681183 Ref: [Expressions of phosphorylated-Smad2 and PTEN in hepatocellular carcinomas and adjacent liver tissues]. PMID: 17711623 Ref: Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues. PMID: 17729405 Ref: Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. PMID: 17786367 Ref: Effects and mechanisms of silibinin on human hepatoma cell lines. PMID: 17879397 Ref: Down-regulation of tumor suppressor gene PTEN, overexpression of p53, plus high proliferating cell nuclear antigen index predict poor patient outcome of hepatocellular carcinoma after resection. PMID: 17982625 Ref: [Study of antitumous effect of the complex prescription of Chinese crude drug in athymic mice with HCC]. PMID: 18323213 |
Ref: Immunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease. PMID: 17763954 Ref: PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. PMID: 18166358 Ref: Expression of phosphatase and tensin homolog deleted on chromosome ten in liver of athymic mice with hepatocellular carcinoma and the effect of Fuzheng Jiedu Decoction. PMID: 18176971 Ref: [Expression of survivin, p27 and PTEN in hepatocellular carcinoma and their clinical significances]. PMID: 18226337 Ref: Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. PMID: 18435927 Ref: Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells. PMID: 18454050 Ref: Osteogenic tumours in Lkb1-deficient mice. PMID: 18761009 Ref: PTEN at the crossroad of metabolic diseases and cancer in the liver. PMID: 18772845 Ref: Pivotal role of mTOR signaling in hepatocellular carcinoma. PMID: 18929564 |
Ref: Differences in molecular alterations of hepatocellular carcinoma between patients with a sustained virological response and those with hepatitis C virus infection. PMID: 18492017 Ref: Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. PMID: 19008348 Ref: Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms. PMID: 19082655 Ref: Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation. PMID: 19141026 Ref: Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. PMID: 19162361 Ref: Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9. PMID: 19208038 Ref: Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN. PMID: 19398230 Ref: Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice. PMID: 19399925 Ref: Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARgamma signaling pathway. PMID: 19684609 Ref: [Effect of Jianpi Jiedu decoction to PTEN/ERK1 of athymic mice with hepatocellular carcinoma]. PMID: 19685755 Ref: Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. PMID: 19711427 Ref: A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. PMID: 19737952 Ref: miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. PMID: 19962668 Ref: Molecular mechanisms underlying hepatocellular carcinoma. PMID: 21994573 |
Ref: The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma. PMID: 19301157 Ref: Morin fosters apoptosis in experimental hepatocellular carcinogenesis model. PMID: 19931519 Ref: VHL and PTEN loss coordinate to promote mouse liver vascular lesions. PMID: 20221685 Ref: PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway. PMID: 20428814 Ref: PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells. PMID: 20430845 Ref: MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. PMID: 20447717 Ref: PTEN in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and cancer. PMID: 20460918 Ref: Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell. PMID: 20467490 Ref: The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. PMID: 20530665 Ref: Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. PMID: 20564331 Ref: Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. PMID: 20837017 Ref: PTEN in liver diseases and cancer. PMID: 20872961 Ref: Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma. PMID: 21105107 Ref: Increased DJ-1 and its prognostic significance in hepatocellular carcinoma. PMID: 21410067 |
Ref: Alpha-fetoprotein: a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cell lines. PMID: 20473866 Ref: ESM-1 silencing decreased cell survival, migration, and invasion and modulated cell cycle progression in hepatocellular carcinoma. PMID: 20821239 Ref: Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation. PMID: 20979057 Ref: Association of PTEN polymorphisms with susceptibility to hepatocellular carcinoma in a Han Chinese population. PMID: 21138334 Ref: Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype. PMID: 21145819 Ref: Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis. PMID: 21145824 Ref: Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice. PMID: 21147764 Ref: Cowden syndrome complicated with hepatocellular carcinoma possibly originating from non-alcoholic steatohepatitis (NASH). PMID: 21269388 Ref: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes. PMID: 21415306 Ref: Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets. PMID: 21465511 Ref: Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance. PMID: 21520171 Ref: Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model. PMID: 21573166 Ref: MAGI1 inhibits cancer cell migration and invasion of hepatocellular carcinoma via regulating PTEN. PMID: 21685691 Ref: Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. PMID: 21703185 Ref: Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines. PMID: 21725613 Ref: Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models. PMID: 21731504 Ref: Inactivation of PTEN is responsible for the survival of Hep G2 cells in response to etoposide-induced damage. PMID: 21784088 Ref: Effect of Benzothiazole based conjugates in causing apoptosis by Regulating p53, PTEN and MAP Kinase proteins affecting miR-195a and miR-101-1. PMID: 22035408 |
Ref: Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis. PMID: 21469143 Ref: In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2. PMID: 22262409 Ref: Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma. PMID: 22429965 Ref: Role of miR-148a in hepatitis B associated hepatocellular carcinoma. PMID: 22496917 Ref: SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling. PMID: 22552445 Ref: Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. PMID: 22560876 Ref: Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFbeta tumor suppressor signaling pathways. PMID: 22622027 Ref: Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer. PMID: 22688403 Ref: Hepatoma-derived growth factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of phosphatidylinositol 3-kinase/Akt pathway. PMID: 22819846 Ref: Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. PMID: 22898879 Ref: Combined phosphatase and tensin homolog (PTEN) loss and fatty acid synthase (FAS) overexpression worsens the prognosis of Chinese patients with hepatocellular carcinoma. PMID: 22949843 Ref: Side-effects of resveratrol in HepG2 cells: reduced pten and increased bcl-xl mRNA expression. PMID: 22971900 Ref: Gene numerical imbalances in cytological specimens based on fluorescence/chromogenic in situ hybridization analysis. PMID: 23033306 Ref: Mannan-modified Ad5-PTEN treatment combined with docetaxel improves the therapeutic effect in H22 tumor-bearing mice. PMID: 23055722 Ref: The Predictive and Prognostic Significance of c-erb-B2, EGFR, PTEN, mTOR, PI3K, p27, and ERCC1 Expression in Hepatocellular Carcinoma. PMID: 23162604 Ref: PTEN enhances the sensitivity of human hepatocellular carcinoma cells to sorafenib. PMID: 23193917 Ref: [Preliminary investigation of the expression and functions of insulin receptor isoforms in endometrial carcinoma]. PMID: 23302125 Ref: [A study of the relationship between the mutation of PIK3CA, PTEN and the occurrence of liver metastasis of colorectal cancer: survival analysis]. PMID: 23302486 Ref: Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver. PMID: 23552841 |
Ref: Phosphatase and tensin homolog regulates stability and activity of EphB1 receptor. PMID: 23118026 Ref: Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. PMID: 23122111 Ref: Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. PMID: 23141928 Ref: Cyclin-dependent kinase-associated protein phosphatase is overexpressed in alcohol-related hepatocellular carcinoma and influences xenograft tumor growth. PMID: 23292002 Ref: Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. PMID: 23372727 Ref: Akt and mTORC1 have different roles during liver tumorigenesis in mice. PMID: 23376645 Ref: Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways. PMID: 23418359 Ref: MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. PMID: 23471579 Ref: Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib. PMID: 23479136 Ref: Expression and significance of PTEN and miR-92 in hepatocellular carcinoma. PMID: 23546593 Ref: MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways. PMID: 23684551 Ref: Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10. PMID: 23691291 Ref: TGF-beta signaling is often attenuated during hepatotumorigenesis, but is retained for the malignancy of hepatocellular carcinoma cells. PMID: 23704908 Ref: MicroRNA-21 regulates the migration and invasion of a stem-like population in hepatocellular carcinoma. PMID: 23708209 Ref: Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells. PMID: 23721490 Ref: Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. PMID: 23749645 Ref: Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. PMID: 23758232 Ref: Multinucleation regulated by the Akt/PTEN signaling pathway is a survival strategy for HepG2 cells. PMID: 23796964 Ref: [Roles of miR-590-5p and miR-590-3p in the development of hepatocellular carcinoma]. PMID: 23803188 Ref: Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway. PMID: 23807724 Ref: Impaired phosphate and tension homologue deleted on chromosome 10 expression and its prognostic role in radical surgery for hepatocellular carcinoma with family aggregation resulting from hepatitis B and liver cirrhosis. PMID: 23828588 Ref: Somatic changes in primary liver cancer in Russia: a pilot study. PMID: 23830926 Ref: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor alpha (ERRalpha). PMID: 23836899 Ref: The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives. PMID: 23845075 Ref: Prognostic impact of pERK in advanced hepatocellular carcinoma patients treated with sorafenib. PMID: 23845703 Ref: Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression. PMID: 23863156 Ref: Mannan-conjugated adenovirus enhanced gene therapy effects on murine hepatocellular carcinoma cells in vitro and in vivo. PMID: 23937094 Ref: NAFLD, NASH and liver cancer. PMID: 24080776 Ref: Jianpijiedu fang improves survival of hepatocarcinoma mice by affecting phosphatase and tensin homolog, phosphoinositide 3-kinase, and focal adhesion kinase. PMID: 24187869 Ref: [Metformin induces apoptosis in hepatocellular carcinoma Huh-7 cells in vitro and its mechanism]. PMID: 24378094 Ref: Targeted therapies in development for non-small cell lung cancer. PMID: 24574860 |
Ref: Apicidin-resistant HA22T hepatocellular carcinoma cells massively promote pro-survival capability via IGF-IR/PI3K/Akt signaling pathway activation. PMID: 23990456 Ref: Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. PMID: 24027047 Ref: GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. PMID: 24141775 Ref: Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma. PMID: 24214128 Ref: PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis. PMID: 24352616 Ref: miR-338-3p suppresses gastric cancer progression through a PTEN-AKT axis by targeting P-REX2a. PMID: 24375644 Ref: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. PMID: 24395596 Ref: [Rosiglitazone inhibits human HepG2 cell proliferation via PI3K/PTEN/Akt signaling pathway]. PMID: 24491054 Ref: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. PMID: 24563076 Ref: Hepatitis B virus induces cell proliferation via HBx-induced microRNA-21 in hepatocellular carcinoma by targeting programmed cell death protein4 (PDCD4) and phosphatase and tensin homologue (PTEN). PMID: 24633222 Ref: Antitumor effect of a selective COX-2 inhibitor, celecoxib, may be attributed to angiogenesis inhibition through modulating the PTEN/PI3K/Akt/HIF-1 pathway in an H(2)(2) murine hepatocarcinoma model. PMID: 24647425 Ref: A phase I trial of MK-2206 in children with refractory malignancies: a Children's Oncology Group study. PMID: 24664955 Ref: Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN. PMID: 24721996 Ref: MiRNA-99a directly regulates AGO2 through translational repression in hepatocellular carcinoma. PMID: 24732044 Ref: The prognostic value of the Na(+)/ H(+) exchanger regulatory factor 1 (NHERF1) protein in cancer. PMID: 24878819 Ref: The PTEN/NRF2 axis promotes human carcinogenesis. PMID: 24892215 Ref: miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway. PMID: 24911372 Ref: Loss of nuclear PTEN in HCV-infected human hepatocytes. PMID: 25075209 Ref: Downregulation of Notch1 inhibits the invasion of human hepatocellular carcinoma HepG2 and MHCC97H cells through the regulation of PTEN and FAK. PMID: 25110169 Ref: CRISPR-mediated direct mutation of cancer genes in the mouse liver. PMID: 25119044 Ref: Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma. PMID: 25120700 Ref: miR-218 modulate hepatocellular carcinoma cell proliferation through PTEN/AKT/PI3K pathway and HoxA10. PMID: 25120782 Ref: HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. PMID: 25242319 Ref: MicroRNA-492 expression promotes the progression of hepatic cancer by targeting PTEN. PMID: 25253996 Ref: Tumor suppressor micro RNA miR-145 and onco micro RNAs miR-21 and miR-222 expressions are differentially modulated by hepatitis B virus X protein in malignant hepatocytes. PMID: 25260533 Ref: Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway. PMID: 25428915 Ref: Recurrent genetic alterations in hepatitis C-associated hepatocellular carcinoma detected by genomic microarray: a genetic, clinical and pathological correlation study. PMID: 25469175 Ref: Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. PMID: 25499255 Ref: [The anti-apoptotic effect of cytoplasmic alpha-fetoprotein in hepatoma cells induced by all-trans retinoic acid involves activation of the PI3K/AKT signaling pathway]. PMID: 25531381 Ref: Down-regulation of PTEN by HCV core protein through activating nuclear factor-kappaB. PMID: 25550771 Ref: Induction of apoptosis by IGFBP3 overexpression in hepatocellular carcinoma cells. PMID: 25556430 Ref: Combination of Matrine and Sorafenib Decreases the Aggressive Phenotypes of Hepatocellular Carcinoma Cells. PMID: 25721136 |
Ref: miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma. PMID: 24632613 Ref: Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients. PMID: 25043940 Ref: TGF-beta signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. PMID: 25132272 Ref: Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells. PMID: 25178877 Ref: Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice. PMID: 25234947 Ref: Overexpression of miR-218 inhibits hepatocellular carcinoma cell growth through RET. PMID: 25374061 Ref: DJ-1 knockdown inhibits growth and xenograftinduced tumor generation of human hepatocellular carcinoma cells. PMID: 25384406 Ref: Hepatitis C virus NS5A drives a PTEN-PI3K/Akt feedback loop to support cell survival. PMID: 25388655 Ref: Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity. PMID: 25415231 Ref: Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma. PMID: 25427907 Ref: Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. PMID: 25447674 Ref: miR-214 as a key hub that controls cancer networks: small player, multiple functions. PMID: 25501033 Ref: STAT3 regulates the migration and invasion of a stemlike subpopulation through microRNA21 and multiple targets in hepatocellular carcinoma. PMID: 25571964 Ref: PTEN and hTERT gene expression and the correlation with human hepatocellular carcinoma. PMID: 25613699 Ref: Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation. PMID: 25617127 Ref: Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis. PMID: 25623824 Ref: MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. PMID: 25633810 Ref: Inhibition of IRS-1 by hepatitis C virus infection leads to insulin resistance in a PTEN-dependent manner. PMID: 25645159 Ref: MiR-32 induces cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting PTEN. PMID: 25647261 Ref: miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells. PMID: 25714026 Ref: miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. PMID: 25769721 Ref: Alpha-fetoprotein activates AKT/mTOR signaling to promote CXCR4 expression and migration of hepatoma cells. PMID: 25815363 Ref: Von Hippel-Lindau status influences phenotype of liver cancers arising from PTEN loss. PMID: 25844041 Ref: Evaluation of the medicinal herb Graptopetalum paraguayense as a treatment for liver cancer. PMID: 25849560 Ref: Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma. PMID: 25881591 Ref: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells. PMID: 25909289 Ref: MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition. PMID: 25931210 Ref: Argonaute 2 promotes angiogenesis via the PTEN/VEGF signaling pathway in human hepatocellular carcinoma. PMID: 25937637 Ref: Significance of serum microRNA-21 in diagnosis of hepatocellular carcinoma (HCC): clinical analyses of patients and an HCC rat model. PMID: 25973032 Ref: MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma. PMID: 26031366 Ref: miR-494 promotes cell proliferation, migration and invasion, and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN. PMID: 26045065 Ref: 3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling. PMID: 26068982 Ref: Molecular Analysis of AFP and HSA Interactions with PTEN Protein. PMID: 26078940 Ref: HCV infection-associated hepatocellular carcinoma in humanized mice. PMID: 26217396 Ref: Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes. PMID: 26251599 Ref: Matrine derivative WM130 inhibits hepatocellular carcinoma by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways. PMID: 26259512 Ref: Lentiviral-Mediated Short Hairpin RNA Knockdown of MTDH Inhibits Cell Growth and Induces Apoptosis by Regulating the PTEN/AKT Pathway in Hepatocellular Carcinoma. PMID: 26287185 Ref: MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway. PMID: 26311740 Ref: CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice. PMID: 26508638 Ref: CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc. PMID: 26513297 Ref: COX-2 Promotes Migration and Invasion by the Side Population of Cancer Stem Cell-Like Hepatocellular Carcinoma Cells. PMID: 26554780 Ref: Association of PTEN gene polymorphisms with liver cancer risk. PMID: 26823866 |
Ref: Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1. PMID: 25747515 Ref: Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21. PMID: 26404135 Ref: MicroRNA-616 promotes the migration, invasion and epithelial-mesenchymal transition of HCC by targeting PTEN. PMID: 26499912 Ref: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. PMID: 26553052 Ref: Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway. PMID: 26589417 Ref: Epithelial Transforming Growth Factor-beta Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma. PMID: 26627606 Ref: Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options. PMID: 26661118 Ref: MicroRNA-519a promotes tumor growth by targeting PTEN/PI3K/AKT signaling in hepatocellular carcinoma. PMID: 26708293 Ref: Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. PMID: 26750720 Ref: miR-367 promotes proliferation and invasion of hepatocellular carcinoma cells by negatively regulating PTEN. PMID: 26772880 Ref: A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells. PMID: 26794644 Ref: A novel anti-alpha-fetoprotein single-chain variable fragment displays anti-tumor effects in HepG2 cells as a single agent or in combination with paclitaxel. PMID: 26820129 Ref: Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways. PMID: 26861252 Ref: Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status. PMID: 26902406 Ref: MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription. PMID: 26910647 Ref: Associations of components of PTEN/AKT/mTOR pathway with cancer stem cell markers and prognostic value of these biomarkers in hepatocellular carcinoma. PMID: 26932478 Ref: Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers. PMID: 26935703 Ref: MicroRNA 152 regulates hepatic glycogenesis by targeting PTEN. PMID: 26996529 Ref: Upregulation of PREX2 promotes the proliferation and migration of hepatocellular carcinoma cells via PTEN-AKT signaling. PMID: 26998152 Ref: Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice. PMID: 27022031 Ref: Integrative biomarker analyses indicate etiological variations in hepatocellular carcinoma. PMID: 27130844 Ref: MiR-19a, miR-122 and miR-223 are differentially regulated by hepatitis B virus X protein and involve in cell proliferation in hepatoma cells. PMID: 27150195 Ref: Effect of overexpression of PTEN on apoptosis of liver cancer cells. PMID: 27173355 Ref: Human lung cancer-derived microparticles enhanced angiogenesis and growth of hepatoma cells in rodent lung parenchyma. PMID: 27186261 Ref: JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling. PMID: 27259236 Ref: Activation of hepatic stellate cell in Pten null liver injury model. PMID: 27307790 Ref: Metformin mediates resensitivity to 5-fluorouracil in hepatocellular carcinoma via the suppression of YAP. PMID: 27323827 Ref: Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins. PMID: 27369806 Ref: Adenovirus-mediated co-expression of ING4 and PTEN cooperatively enhances their antitumor activity in human hepatocellular carcinoma cells. PMID: 27421660 Ref: NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN. PMID: 27467187 Ref: Does PTEN gene mutation play any role in Li-Fraumeni syndrome. PMID: 27493922 Ref: Clinical effects of miR-101 on prognosis of hepatocellular carcinoma and carcinogenic mechanism of anti-miR-101. PMID: 27498785 Ref: PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. PMID: 27572739 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells. PMID: 27689326 Ref: Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway. PMID: 27840896 Ref: PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma. PMID: 27915333 Ref: Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy. PMID: 27960411 Ref: Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. PMID: 27974211 Ref: Expression and Prognostic Role of FHIT, Fibronectin, and PTEN in Hepatocellular Carcinoma. PMID: 28164627 |
Ref: Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan) platform. PMID: 27663888 Ref: STC2 as a novel mediator for Mus81-dependent proliferation and survival in hepatocellular carcinoma. PMID: 27939696 Ref: Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. PMID: 27993894 Ref: HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN. PMID: 28053323 Ref: Alterations in transcription and protein expressions of HCC-related genes in HepG2 cells caused by microcystin-LR. PMID: 28062358 Ref: PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis. PMID: 28105255 Ref: TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer. PMID: 28114432 Ref: MicroRNA-155-5p promotes hepatocellular carcinoma progression by suppressing PTEN through the PI3K/Akt pathway. PMID: 28132399 Ref: PTEN and TRAIL genes loaded zein nanoparticles as potential therapy for hepatocellular carcinoma. PMID: 28140697 Ref: The Effect of a Histone Deacetylase Inhibitor (AR-42) on Canine Prostate Cancer Growth and Metastasis. PMID: 28181686 Ref: OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and beta-catenin signaling pathways. PMID: 28184024 Ref: Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. PMID: 28205209 Ref: MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. PMID: 28245430 Ref: Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells. PMID: 28288414 Ref: Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles. PMID: 28339069 Ref: Hepatitis B virus X protein increases microRNA21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3kinase/protein kinase B signaling pathway. PMID: 28339072 Ref: TP53 and RET may serve as biomarkers of prognostic evaluation and targeted therapy in hepatocellular carcinoma. PMID: 28350084 Ref: Long non-coding RNA XIST regulates PTEN expression by sponging miR-181a and promotes hepatocellular carcinoma progression. PMID: 28388883 Ref: Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma. PMID: 28411180 Ref: MiR-425-5p promotes invasion and metastasis of hepatocellular carcinoma cells through SCAI-mediated dysregulation of multiple signaling pathways. PMID: 28423650 Ref: Metformin exhibits the anti-proliferation and anti-invasion effects in hepatocellular carcinoma cells after insufficient radiofrequency ablation. PMID: 28450808 Ref: Alpha1-ACT Functions as a Tumour Suppressor in Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Signalling Pathway via Activation of PTEN. PMID: 28456796 Ref: Long Noncoding RNA lncARSR Promotes Doxorubicin Resistance in Hepatocellular Carcinoma via Modulating PTEN-PI3K/Akt Pathway. PMID: 28464252 Ref: The role of miR-130a in cancer. PMID: 28477068 Ref: Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro. PMID: 28498459 Ref: Antibody to human alpha-fetoprotein inhibits cell growth of human hepatocellular carcinoma cells by resuscitating the PTEN molecule: in vitro experiments. PMID: 28498467 Ref: Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. PMID: 28504722 Ref: CRISPR/Cas9-based Pten knock-out and Sleeping Beauty Transposon-mediated Nras knock-in induces hepatocellular carcinoma and hepatic lipid accumulation in mice. PMID: 28513320 Ref: Aptamer-mediated gene therapy enhanced antitumor activity against human hepatocellular carcinoma in vitro and in vivo. PMID: 28522194 Ref: The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2. PMID: 28522832 Ref: Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice. PMID: 28533225 Ref: CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice. PMID: 28584302 Ref: PTEN: A potential prognostic marker in virus-induced hepatocellular carcinoma. PMID: 28621226 Ref: The role of PTEN - HCV core interaction in hepatitis C virus replication. PMID: 28623358 Ref: Wnt/beta-catenin activation and macrophage induction during liver cancer development following steatosis. PMID: 28671671 Ref: Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways. PMID: 28698660 Ref: New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. PMID: 28715695 Ref: Inhibitory effects of 1,25(OH)2D3 on the proliferation of hepatocellular carcinoma cells through the downregulation of HDAC2. PMID: 28737824 Ref: Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway. PMID: 28769986 Ref: Treatment with PTEN-Long protein inhibits hepatitis C virus replication. PMID: 28783500 Ref: ONTD induces growth arrest and apoptosis of human hepatoma Bel-7402 cells though a peroxisome proliferator-activated receptor gamma-dependent pathway. PMID: 28834734 Ref: Effect and Mechanism of Sophoridine to suppress Hepatocellular carcinoma in vitro and vivo. PMID: 28858730 Ref: Combination of AAV-TRAIL with miR-221-Zip Therapeutic Strategy Overcomes the Resistance to TRAIL Induced Apoptosis in Liver Cancer. PMID: 28900506 Ref: Long non-coding RNA 657 suppresses hepatocellular carcinoma cell growth by acting as a molecular sponge of miR-106a-5p to regulate PTEN expression. PMID: 28919047 Ref: NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma. PMID: 28928809 Ref: Ligands of the peroxisome proliferator-activated receptor gamma inhibit hepatoce llular carcinoma cell proliferation. PMID: 28943966 Ref: Correlation between expression levels of PTEN and p53 genes and the clinical features of HBsAg-positive liver cancer. PMID: 28952211 Ref: MicroRNA-205-5p regulates the chemotherapeutic resistance of hepatocellular carcinoma cells by targeting PTEN/JNK/ANXA3 pathway. PMID: 28979703 Ref: Regulation of ERK and AKT pathways by hepatitis B virus X protein via the Notch1 pathway in hepatocellular carcinoma. PMID: 29048612 Ref: Spermine oxidase promotes bile canalicular lumen formation through acrolein production. PMID: 29093526 Ref: Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development. PMID: 29152604 Ref: Long Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression. PMID: 29179215 Ref: MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis. PMID: 29179453 Ref: Long non-coding RNA PTENP1 interacts with miR-193a-3p to suppress cell migration and invasion through the PTEN pathway in hepatocellular carcinoma. PMID: 29296207 Ref: Fisetin Attenuates AKT Associated Growth Promoting Events in AflatoxinB1 Induced Hepatocellular Carcinoma. PMID: 29298655 Ref: C21 steroid-enriched fraction refined from Marsdenia tenacissima inhibits hepatocellular carcinoma through the coordination of Hippo-Yap and PTEN-PI3K/AKT signaling pathways. PMID: 29299170 Ref: Curcumin combined with glycyrrhetinic acid inhibits the development of hepatocellular carcinoma cells by down-regulating the PTEN/PI3K/AKT signalling pathway. PMID: 29312508 Ref: The tyrosine kinase inhibitors effects on metastatic tumor graft in the chick chorioallantoic membrane assay. PMID: 29556614 Ref: Comparison of Subtypes of Hepatocellular Adenoma to Hepatocellular Carcinoma and Non-Neoplastic Liver Tissue in Terms of PTEN Expression. PMID: 29687774 |
Ref: Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo. PMID: 28833603 Ref: Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness. PMID: 29152770 Ref: Synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib in hepatocellular carcinoma by modulating PTEN/Akt signaling pathway. PMID: 29156516 Ref: C/EBPalpha-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. PMID: 29159818 Ref: Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level. PMID: 29283497 Ref: Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway. PMID: 29303510 Ref: Depletion of S100A4(+) stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors. PMID: 29303514 Ref: The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma. PMID: 29305580 Ref: Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy. PMID: 29385181 Ref: Erratum: Argonaute 2 promotes angiogenesis via the PTEN/VEGF signaling pathway in human hepatocellular carcinoma. PMID: 29388571 Ref: Pterostilbene increases PTEN expression through the targeted downregulation of microRNA-19a in hepatocellular carcinoma. PMID: 29393488 Ref: Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. PMID: 29400692 Ref: miR-106b-5p promotes stem cell-like properties of hepatocellular carcinoma cells by targeting PTEN via PI3K/Akt pathway. PMID: 29416358 Ref: Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting beta-catenin by activating PKM2 and inactivating PTEN. PMID: 29449541 Ref: Combination of Kras activation and PTEN deletion contributes to murine hepatopancreatic ductal malignancy. PMID: 29452147 Ref: Characterization of aptamer-mediated gene delivery system for liver cancer therapy. PMID: 29467932 Ref: Downregulated miR-23b-3p expression acts as a predictor of hepatocellular carcinoma progression: A study based on public data and RT-qPCR verification. PMID: 29484429 Ref: High-expressed CKS2 is associated with hepatocellular carcinoma cell proliferation through down-regulating PTEN. PMID: 29487004 Ref: Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. PMID: 29487225 Ref: Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway. PMID: 29520149 Ref: C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells. PMID: 29523159 Ref: Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway. PMID: 29530052 Ref: Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells. PMID: 29530069 Ref: Resolvin D1 attenuates liver ischaemia/reperfusion injury through modulating thioredoxin 2-mediated mitochondrial quality control. PMID: 29569721 Ref: Pterostilbene inhibits MTA1/HDAC1 complex leading to PTEN acetylation in hepatocellular carcinoma. PMID: 29635894 Ref: Total Flavonoids from Oroxylum indicum Induce Apoptosis via PI3K/Akt/PTEN Signaling Pathway in Liver Cancer. PMID: 29636773 Ref: Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. PMID: 29669855 Ref: Naringenin improve hepatitis C virus infection induced insulin resistance by increase PTEN expression via p53-dependent manner. PMID: 29684853 Ref: Insulin receptor substrate 2: a bridge between Hippo and AKT pathways. PMID: 29699606 Ref: The phosphoinositide 3-kinase (PI3K) pathway and glycogen synthase kinase-3 (GSK-3) positively regulate the activity of metal-responsive transcription factor-1 (MTF-1) in response to zinc ions. PMID: 29707960 Ref: Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis. PMID: 29717200 Ref: Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer. PMID: 29720833 Ref: An important role of SREBP-1 in HBV and HCV co-replication inhibition by PTEN. PMID: 29803738 Ref: [Effect of Gleditsia sinesis extract on miRNA21 and PTEN gene in liver cancer rat]. PMID: 29804382 Ref: Suppression of miR-21 Expression Inhibits Cell Proliferation and Migration of Liver Cancer Cells by Targeting Phosphatase and Tensin Homolog (PTEN). PMID: 29807978 Ref: Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelialmesenchymal transition. PMID: 29845189 Ref: miR372 Promotes Progression of Liver Cancer Cells by Upregulating erbB-2 through Enhancement of YB-1. PMID: 29858084 Ref: Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a. PMID: 29895332 Ref: NAFLD Related-HCC: The Relationship with Metabolic Disorders. PMID: 29956206 Ref: HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression. PMID: 29958993 Ref: MicroRNA-760 Inhibits Doxorubicin Resistance in Hepatocellular Carcinoma through Regulating Notch1/Hes1-PTEN/Akt Signaling Pathway. PMID: 29968951 Ref: Comparing Clonality Between Components of Combined Hepatocellular Carcinoma and Cholangiocarcinoma by Targeted Sequencing. PMID: 29976634 Ref: Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. PMID: 29976840 Ref: MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN. PMID: 29992971 Ref: Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma. PMID: 30017965 Ref: microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma. PMID: 30021351 Ref: Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis. PMID: 30034633 Ref: USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma. PMID: 30056112 Ref: XIST Induced by JPX Suppresses Hepatocellular Carcinoma by Sponging miR-155-5p. PMID: 30091314 Ref: A Survey of Molecular Heterogeneity in Hepatocellular Carcinoma. PMID: 30094405 Ref: BMI1 and PTEN are key determinants of breast cancer therapy: A plausible therapeutic target in breast cancer. PMID: 30096458 Ref: Long non-coding RNA THOR promotes cell proliferation and metastasis in hepatocellular carcinoma. PMID: 30098425 Ref: Pten Haplodeficiency Accelerates Liver Tumor Growth in miR-122a-Null Mice via Expansion of Periportal Hepatocyte-Like Cells. PMID: 30165041 Ref: Fresh red raspberry phytochemicals suppress the growth of hepatocellular carcinoma cells by PTEN/AKT pathway. PMID: 30195065 Ref: Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease. PMID: 30201631 Ref: Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents. PMID: 30251900 Ref: Knockdown of Ubiquitin Associated Protein 2-Like (UBAP2L) Inhibits Growth and Metastasis of Hepatocellular Carcinoma. PMID: 30291221 Ref: Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling. PMID: 30301886 Ref: [The effect of miR-155 on HBV replication and PTEN expression in vivo]. PMID: 30317769 Ref: PTEN Expression, Not Mutation Status for TSC1, TSC2 or mTOR, Correlates With Outcome on Everolimus in Patients With Renal Cell Carcinoma Treated on RECORD-3. PMID: 30327302 Ref: Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis. PMID: 30327349 Ref: Downregulated miR-328 suppressed cell invasion and growth in hepatocellular carcinoma via targeting PTEN. PMID: 30338800 |