Primary Site >> Colorectal Cancer
Gene >> PTEN
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Ref: Mortality among workers from a plastics producing plant: a matched case-control study nested in a retrospective cohort study. PMID: 6682438 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. PMID: 9708796 Ref: [Systematic internal quality control in surgery 1993 to 1997]. PMID: 10028600 |
Ref: Causes and consequences of microsatellite instability in endometrial carcinoma. PMID: 9927063 Ref: Alterations of the PPP1R3 gene in human cancer. PMID: 10485448 |
Ref: Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. PMID: 10607839 Ref: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. PMID: 10972292 Ref: Hereditary colorectal cancer: risk assessment and management. PMID: 11005140 Ref: Analysis of the PTEN gene mutation in polyposis syndromes and sporadic gastrointestinal tumors in Japanese patients. PMID: 11052475 |
Ref: Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-beta receptor III. PMID: 11029459 Ref: Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. PMID: 11251179 Ref: Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation. PMID: 11313308 Ref: Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. PMID: 11378386 Ref: PTEN expression is maintained in sporadic colorectal tumours. PMID: 11439367 Ref: Microsatellite instability, PTEN and p53 germline mutations in glioma families. PMID: 11669337 Ref: PTEN gene mutations in colorectal cancers displaying microsatellite instability. PMID: 11689295 Ref: Colorectal carcinomas and PTEN/MMAC1 gene mutations. PMID: 11751500 |
Ref: Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors. PMID: 11854177 Ref: PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow. PMID: 11857088 Ref: Considerations when analyzing the methylation status of PTEN tumor suppressor gene. PMID: 11891178 Ref: Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. PMID: 12057899 Ref: Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells. PMID: 12140294 Ref: Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. PMID: 12145277 Ref: PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. PMID: 12163369 Ref: PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. PMID: 12360479 |
Ref: Signaling inhibition with radiation in colorectal cancer: clinical trials. PMID: 12802796 Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 Ref: Intratumoral heterogeneity in microsatellite alterations in BRCA1 and PTEN regions in sporadic colorectal cancer. PMID: 14527905 Ref: Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo. PMID: 14528320 Ref: Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells. PMID: 14605666 Ref: Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer. PMID: 15235134 |
Ref: Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. PMID: 14578160 Ref: PTEN mutations are common in sporadic microsatellite stable colorectal cancer. PMID: 14724591 Ref: [Expression and clinical significance of survivin gene and PTEN protein in colorectal adenocarcinoma]. PMID: 15025964 Ref: Loss of heterozygosity on 10q and mutational status of PTEN and BMPR1A in colorectal primary tumours and metastases. PMID: 15026806 Ref: Inverse PCR-based RFLP scanning identifies low-level mutation signatures in colon cells and tumors. PMID: 15059910 Ref: Identification of a novel binding partners for tumor suppressor PTEN by a yeast two-hybrid approach. PMID: 15112574 Ref: Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. PMID: 15126336 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 Ref: NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs. PMID: 15240129 Ref: Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series. PMID: 15361209 Ref: Akt: a potential target for thyroid cancer therapy. PMID: 15379721 Ref: Molecular basis and diagnostics of hereditary colorectal cancers. PMID: 15478312 Ref: PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer. PMID: 15520163 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 Ref: Inhibition of transfected PTEN on human colon cancer. PMID: 15534929 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: Genotype phenotype correlations in Israeli colorectal cancer patients. PMID: 15523694 Ref: The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. PMID: 15592509 Ref: A genetic screen for candidate tumor suppressors identifies REST. PMID: 15960972 Ref: Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity. PMID: 16157051 Ref: [Refined mapping of loss of heterzygosity on 10q23-24 in sporadic colorectal carcinoma]. PMID: 16313823 |
Ref: Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. PMID: 16421660 Ref: Microsatellite instability in colorectal cancer. PMID: 16555243 Ref: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. PMID: 16574813 Ref: Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer. PMID: 16719202 Ref: Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. PMID: 16772787 Ref: MSH2 splice site mutation and endometrial cancer. PMID: 16803540 Ref: Multiple colon carcinomas in a patient with Cowden syndrome. PMID: 16964417 |
Ref: The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. PMID: 17087942 Ref: Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. PMID: 17278192 Ref: Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. PMID: 17314276 Ref: Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium. PMID: 17365822 Ref: PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. PMID: 17409395 Ref: Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. PMID: 17693663 Ref: Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition. PMID: 17699782 Ref: [Effect of lipoteichoic acid of Bifidobacterium on survivin and its regulatory genes]. PMID: 17892124 Ref: The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor. PMID: 17909040 Ref: BMP suppresses PTEN expression via RAS/ERK signaling. PMID: 18059158 |
Ref: Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. PMID: 18095365 Ref: Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population. PMID: 18193083 Ref: Potential predictive markers of response to EGFR-targeted therapies in colorectal cancer. PMID: 18206383 Ref: The AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN gene. PMID: 18316341 Ref: PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. PMID: 18339877 Ref: Loss of XIAP sensitizes rosiglitazone-induced growth inhibition of colon cancer in vivo. PMID: 18351648 Ref: Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. PMID: 18413805 Ref: Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence? PMID: 18440486 Ref: Variable phenotypes associated with 10q23 microdeletions involving the PTEN and BMPR1A genes. PMID: 18510548 Ref: In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation. PMID: 18524847 Ref: PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. PMID: 18544567 Ref: Single cell cytometry of protein function in RNAi treated cells and in native populations. PMID: 18673568 Ref: Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study. PMID: 18700047 Ref: PTEN-deficient cancers depend on PIK3CB. PMID: 18755892 Ref: TGFbeta modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells. PMID: 18769113 Ref: Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status. PMID: 18781614 Ref: LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. PMID: 18794113 Ref: Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas. PMID: 19024597 Ref: Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival. PMID: 19036165 Ref: Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. PMID: 19075230 Ref: Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. PMID: 19117505 Ref: [Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]. PMID: 19140325 |
Ref: PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. PMID: 18669866 Ref: Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints. PMID: 18977806 Ref: Endometrial cancer and somatic G>T KRAS transversion in patients with constitutional MUTYH biallelic mutations. PMID: 18980800 Ref: TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. PMID: 19017743 Ref: Resistance to EGF-R (erbB-1) and VEGF-R modulating agents. PMID: 19124237 Ref: PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. PMID: 19223544 Ref: A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. PMID: 19251594 Ref: Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant. PMID: 19293803 Ref: p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. PMID: 19343039 Ref: Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. PMID: 19359472 Ref: Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf. PMID: 19378335 Ref: Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs. PMID: 19433066 Ref: Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function. PMID: 19457929 Ref: Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. PMID: 19503063 Ref: Inhibition of p38alpha unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism. PMID: 19587525 Ref: [Status of components in EGFR-related signal transduction as predictive markers for anti-EGFR antibody therapy in colorectal cancer treatment]. PMID: 19620792 Ref: Anti-EGFR therapy in colorectal cancer: how to choose the right patient. PMID: 19663767 Ref: No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer. PMID: 19673018 Ref: PTEN expression and mutation in colorectal carcinomas. PMID: 19724853 Ref: Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. PMID: 19738166 Ref: [The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma]. PMID: 19764563 Ref: Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer. PMID: 19787250 Ref: An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression. PMID: 19789347 Ref: Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer. PMID: 19806185 Ref: Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology. PMID: 19892662 Ref: Biomarkers and anti-EGFR therapies for KRAS wild-type metastatic colorectal cancer. PMID: 19917537 Ref: Accomplishments in 2008 in biologic markers for gastrointestinal cancers-focus on colorectal cancer. PMID: 20011570 Ref: PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells. PMID: 20032390 Ref: [Change from inflammation to carcinoma in ulcerative colitis: the role of PTEN/PI3K/AKT]. PMID: 20067111 Ref: The dark side of the moon: the PI3K/PTEN/AKT pathway in colorectal carcinoma. PMID: 20130434 Ref: [Biomarkers and anti-EGFR therapies for KRAS wild-type tumors in metastatic colorectal cancer patients]. PMID: 20432670 |
Ref: Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer. PMID: 19731079 Ref: Recent insights into the pathogenesis of colorectal cancer. PMID: 19786869 Ref: Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. PMID: 19911253 Ref: PTEN status in advanced colorectal cancer treated with cetuximab. PMID: 19953097 Ref: Anti-epidermal growth factor receptor antibodies in the treatment of metastatic colorectal cancer. PMID: 19954416 Ref: Coexpression of biological key modulators in primary colorectal carcinomas and related metastatic sites: implications for treatment with cetuximab. PMID: 20085858 Ref: Molecular predictors of efficacy to anti-EGFR agents in colorectal cancer patients. PMID: 20088793 Ref: Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. PMID: 20100961 Ref: Clinical and molecular characterization of individuals with recurrent genomic disorder at 10q22.3q23.2. PMID: 20345475 Ref: Oncogenic mutations as predictive factors in colorectal cancer. PMID: 20383189 Ref: Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. PMID: 20413299 Ref: Recent patents and advances in genomic biomarker discovery for colorectal cancers. PMID: 20426761 Ref: The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy. PMID: 20551061 Ref: Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells. PMID: 20566622 Ref: Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers. PMID: 20600018 Ref: Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. PMID: 20622004 Ref: Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells. PMID: 20624167 Ref: Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFbeta signaling pathway in SW480 cells. PMID: 20637737 Ref: Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. PMID: 20664949 Ref: KRAS mutation testing of colorectal cancer for anti-EGFR therapy: dogmas versus evidence. PMID: 20718705 Ref: Predictive molecular markers of response to epidermal growth factor receptor(EGFR) family-targeted therapies. PMID: 20718710 Ref: Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. PMID: 20729907 Ref: DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset. PMID: 21103049 Ref: MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration. PMID: 21118966 Ref: Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer. PMID: 21139621 Ref: Impact of KRAS mutation and PTEN expression on cetuximab-treated colorectal cancer. PMID: 21155011 Ref: [Expression of phosphatase and tensin homolog in lower rectal cancer on neoadjuvant chemoradiotherapy]. PMID: 21162897 Ref: The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PMID: 21203412 Ref: Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer. PMID: 21412012 |
Ref: Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. PMID: 20812030 Ref: EGFR and HER3 mRNA expression levels predict distant metastases in locally advanced rectal cancer. PMID: 20824716 Ref: Evidence for an hMSH3 defect in familial hamartomatous polyps. PMID: 20845481 Ref: Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice. PMID: 20951698 Ref: Deregulated expression of sprouty2 and microRNA-21 in human colon cancer: Correlation with the clinical stage of the disease. PMID: 21099344 Ref: Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal carcinoma cells. PMID: 21102582 Ref: Deranged Wnt signaling is frequent in hereditary nonpolyposis colorectal cancer. PMID: 21132538 Ref: KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. PMID: 21163703 Ref: Clinical significance of tumor suppressor PTEN in colorectal carcinoma. PMID: 21194879 Ref: Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in >/= 2 line cetuximab-based therapy of colorectal cancer patients. PMID: 21283802 Ref: Cetuximab enhances the activities of irinotecan on gastric cancer cell lines through downregulating the EGFR pathway upregulated by irinotecan. PMID: 21286718 Ref: Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer. PMID: 21340604 Ref: Multiple primary malignancies and subtle mucocutaneous lesions associated with a novel PTEN gene mutation in a patient with Cowden syndrome: case report. PMID: 21406108 Ref: Molecular predictors of response to chemotherapy in colorectal cancer. PMID: 21427555 Ref: The endothelin axis in the metastatic process of colon carcinoma. PMID: 21498707 Ref: Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. PMID: 21594648 Ref: Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer. PMID: 21632860 Ref: The status of EGFR-associated genes could predict the outcome and tumor response of chemo-refractory metastatic colorectal patients using cetuximab and chemotherapy. PMID: 21671463 Ref: Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer? PMID: 21729677 Ref: Concordance of predictive markers for EGFR inhibitors in primary tumors and metastases in colorectal cancer: a review. PMID: 21742964 Ref: [Predictive biomarkers of anti-EGFR monoclonal anti-body in colorectal cancer]. PMID: 21772090 Ref: Glucose metabolism measured by [(1)(8)F]fluorodeoxyglucose positron emission tomography is independent of PTEN/AKT status in human colon carcinoma cells. PMID: 21804920 Ref: Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. PMID: 21806946 Ref: Predictive molecular classifiers in colorectal cancer. PMID: 21810517 Ref: [KRAS mutation test]. PMID: 21815483 Ref: Intestinal epithelial-specific PTEN inactivation results in tumor formation. PMID: 21836055 Ref: Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells. PMID: 21873159 Ref: The significance of a group of molecular markers and clinicopathological factors in identifying colorectal liver metastasis. PMID: 21937374 Ref: Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment. PMID: 21999454 Ref: Influences of laparoscopic resection on expressions of metastasis genes in colorectal cancer: report of microarray analysis and literature review. PMID: 22024071 Ref: Hedgehog signaling and the Gli code in stem cells, cancer, and metastases. PMID: 22114144 Ref: [Molecular predictive markers of EGFR-targeted therapy in metastatic colorectal cancer]. PMID: 22145213 Ref: Expression of PPARgamma and PTEN in human colorectal cancer: An immunohistochemical study using tissue microarray methodology. PMID: 22848291 Ref: Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program. PMID: 23238744 |
Ref: PTEN in colorectal cancer: a report on two Cowden syndrome patients. PMID: 21291452 Ref: The pro-apoptotic effect of quercetin in cancer cell lines requires ERbeta-dependent signals. PMID: 21732360 Ref: Management of advanced colon cancer in a community hospital--impact of age on clinical management and survival. PMID: 21796331 Ref: Juvenile polyposis and other intestinal polyposis syndromes with microdeletions of chromosome 10q22-23. PMID: 21834858 Ref: Stage-dependent differential expression of microRNAs in colorectal cancer: potential role as markers of metastatic disease. PMID: 22120473 Ref: Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212. PMID: 22169769 Ref: Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. PMID: 22173549 Ref: Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients:implications for cancer therapy. PMID: 22229245 Ref: Lifetime cancer risks in individuals with germline PTEN mutations. PMID: 22252256 Ref: PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation. PMID: 22252525 Ref: Emerging role of cetuximab in the treatment of colorectal cancer. PMID: 22264223 Ref: PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer. PMID: 22285706 Ref: MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. PMID: 22322462 Ref: Role of Sulindac and Celecoxib in the regulation of angiogenesis during the early neoplasm of colon: exploring PI3-K/PTEN/Akt pathway to the canonical Wnt/beta-catenin signaling. PMID: 22397759 Ref: PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3beta signaling pathway in DMH induced early colon carcinogenesis in rat. PMID: 22561258 Ref: KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer. PMID: 22586484 Ref: Loss of PTEN expression as a predictor of resistance to anti-EGFR monoclonal therapy in metastatic colorectal cancer: evidence from retrospective studies. PMID: 22610356 Ref: Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors. PMID: 22660396 Ref: Is colorectal surveillance indicated in patients with PTEN mutations? PMID: 22672595 Ref: Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer. PMID: 22682314 Ref: Phosphatase and tensin homolog expression related to cetuximab effects in colorectal cancer patients: a meta-analysis. PMID: 22690082 Ref: Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer. PMID: 22717106 Ref: Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials. PMID: 22723336 Ref: ESM-1 regulates cell growth and metastatic process through activation of NF-kappaB in colorectal cancer. PMID: 22735811 Ref: Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM). PMID: 22855150 Ref: Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers. PMID: 22870330 Ref: Phase I study of the antiangiogenic antibody bevacizumab and the mTOR/hypoxia-inducible factor inhibitor temsirolimus combined with liposomal doxorubicin: tolerance and biological activity. PMID: 22927482 Ref: The prognostic value of the immunohistochemical aspects of tumor suppressor genes p53, bcl-2, PTEN and nuclear proliferative antigen Ki-67 in resected colorectal carcinoma. PMID: 22990545 Ref: Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. PMID: 22992293 Ref: microRNA-181a is associated with poor prognosis of colorectal cancer. PMID: 23023298 Ref: Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules. PMID: 23033949 Ref: KRAS mutation testing in metastatic colorectal cancer. PMID: 23066310 Ref: Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer. PMID: 23170117 Ref: [A study of the relationship between the mutation of PIK3CA, PTEN and the occurrence of liver metastasis of colorectal cancer: survival analysis]. PMID: 23302486 Ref: Analysis of PTEN, VEGF, HER2 and P53 status in determining colorectal cancer benefit from bevacizumab therapy. PMID: 23464465 Ref: [Competing endogenous RNA regulation mechanism and its role in the development and progression of colorectal cancer]. PMID: 23596669 |
Ref: Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. PMID: 22308110 Ref: Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARgamma-targeted therapy. PMID: 22543585 Ref: Association of epigenetic alteration in PTEN gene with colorectal cancer progression among Indian population. PMID: 22552802 Ref: Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations. PMID: 22647972 Ref: KRAS mutation status and clinical outcome of preoperative chemoradiation with cetuximab in locally advanced rectal cancer: a pooled analysis of 2 phase II trials. PMID: 22672749 Ref: Combined analysis of KRAS and PIK3CA mutations, MET and PTEN expression in primary tumors and corresponding metastases in colorectal cancer. PMID: 22936063 Ref: Clinical significance of MMP-7 and PTEN expression in colorectal cancer. PMID: 22944341 Ref: PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma. PMID: 22955107 Ref: NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway. PMID: 22974840 Ref: Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a. PMID: 22978663 Ref: Single-agent therapy with sorafenib or 5-FU is equally effective in human colorectal cancer xenograft--no benefit of combination therapy. PMID: 22983756 Ref: KRAS p.G13D mutations are associated with sensitivity to anti-EGFR antibody treatment in colorectal cancer cell lines. PMID: 23015072 Ref: Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. PMID: 23027128 Ref: Association between PTEN IVS4 polymorphism and development of colorectal cancer in a Turkish population. PMID: 23062208 Ref: Epidermal growth factor receptor, phosphatidylinositol-3-kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas: loss of PTEN is associated with worse clinical outcome. PMID: 23158210 Ref: MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells. PMID: 23174819 Ref: Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. PMID: 23251002 Ref: Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report. PMID: 23279635 Ref: Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: overcoming the mechanisms of cancer cell resistance. PMID: 23281932 Ref: Targeted therapies in colorectal cancer-an integrative view by PPPM. PMID: 23356214 Ref: Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. PMID: 23372727 Ref: PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. PMID: 23392169 Ref: Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells. PMID: 23420047 Ref: Recommendations from the EGAPP Working Group: can testing of tumor tissue for mutations in EGFR pathway downstream effector genes in patients with metastatic colorectal cancer improve health outcomes by guiding decisions regarding anti-EGFR therapy? PMID: 23429431 Ref: Altered PTEN function caused by deletion or gene disruption is associated with poor prognosis in rectal but not in colon cancer. PMID: 23465274 Ref: Effect of adenovirus-mediated PTEN gene on ulcerative colitis-associated colorectal cancer. PMID: 23516074 Ref: CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a. PMID: 23533633 Ref: Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients. PMID: 23544471 Ref: Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells. PMID: 23588203 Ref: MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells. PMID: 23617834 Ref: Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer. PMID: 23623571 Ref: PTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions. PMID: 23625595 Ref: Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells. PMID: 23629727 Ref: PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer. PMID: 23633456 Ref: The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer. PMID: 23660947 Ref: [Anti-microRNA-221 enhances radiosensitivity of colorectal carcinoma cells by up-regulating PTEN]. PMID: 23688995 Ref: Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways. PMID: 23725112 Ref: PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer. PMID: 23785454 Ref: Phosphatase and tensin homologue deleted on chromosome 10. PMID: 23798791 Ref: [Construction of microRNA-21 and PTEN eukaryotic expression and short hairpin RNA expression vectors]. PMID: 23858763 Ref: Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation. PMID: 23872169 Ref: Feasibility of preemptive biomarker profiling for personalised early clinical drug development at a Comprehensive Cancer Center. PMID: 23876834 Ref: Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase. PMID: 23883586 Ref: Differential expression of PTEN gene correlates with phenotypic heterogeneity in three cases of patients showing clinical manifestations of PTEN hamartoma tumour syndrome. PMID: 23886400 Ref: Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21. PMID: 23894315 Ref: Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab. PMID: 23930204 Ref: Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. PMID: 23934261 Ref: Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis. PMID: 23934607 Ref: Genotype directed therapy in murine mismatch repair deficient tumors. PMID: 23935891 Ref: Toward a comprehensive and systematic methylome signature in colorectal cancers. PMID: 23975090 Ref: Molecular alterations of Ras-Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt signaling pathways in colorectal cancers from a tertiary hospital at Kuala Lumpur, Malaysia. PMID: 23992303 Ref: MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. PMID: 24027433 Ref: Epigenetic and genetic features of 24 colon cancer cell lines. PMID: 24042735 Ref: BRAF V600E is a determinant of sensitivity to proteasome inhibitors. PMID: 24107445 Ref: The relationship between and clinical significance of MicroRNA-32 and phosphatase and tensin homologue expression in colorectal cancer. PMID: 24123284 Ref: Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. PMID: 24136893 Ref: Association of candidate single nucleotide polymorphisms with somatic mutation of the epidermal growth factor receptor pathway. PMID: 24152305 Ref: PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. PMID: 24156022 Ref: Multigene assays in metastatic colorectal cancer. PMID: 24158971 Ref: Curcumin cytotoxicity is enhanced by PTEN disruption in colorectal cancer cells. PMID: 24187456 Ref: Personalized treatment for advanced colorectal cancer: KRAS and beyond. PMID: 24294007 Ref: A novel germline mutation in exon 10 of the SMAD4 gene in a familial juvenile polyposis. PMID: 24312718 Ref: PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system. PMID: 24348097 Ref: Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis. PMID: 24379584 Ref: Anti-miRNA-221 sensitizes human colorectal carcinoma cells to radiation by upregulating PTEN. PMID: 24409057 Ref: Functions and Regulation of the PTEN Gene in Colorectal Cancer. PMID: 24475377 |
Ref: Mutational and expressional analyses of PTEN gene in colorectal cancer from Northern India. PMID: 23359334 Ref: Inactivation of TGF-beta signaling and loss of PTEN cooperate to induce colon cancer in vivo. PMID: 23604118 Ref: Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: meta-analysis, co-occurrence and ethnic variation. PMID: 23960014 Ref: MicroRNA-92a functions as an oncogene in colorectal cancer by targeting PTEN. PMID: 24026406 Ref: Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma. PMID: 24052409 Ref: p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. PMID: 24141722 Ref: Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer. PMID: 24200851 Ref: Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38alpha modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. PMID: 24215867 Ref: PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17. PMID: 24218517 Ref: PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. PMID: 24293351 Ref: Mismatch repair deficiency in ovarian cancer -- molecular characteristics and clinical implications. PMID: 24333356 Ref: Fish oil suppresses cell growth and metastatic potential by regulating PTEN and NF-kappaB signaling in colorectal cancer. PMID: 24416253 Ref: MHY-449, a novel dihydrobenzofuro[4,5-b][1,8] naphthyridin-6-one derivative, induces apoptotic cell death through modulation of Akt/FoxO1 and ERK signaling in PC3 human prostate cancer cells. PMID: 24424889 Ref: Is biomarker research advancing in the era of personalized medicine for head and neck cancer? PMID: 24442754 Ref: Biomarkers for predicting the efficacy of anti-epidermal growth factor receptor antibody in the treatment of colorectal cancer. PMID: 24458108 Ref: MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer. PMID: 24468585 Ref: Overexpression of MET is a new predictive marker for anti-EGFR therapy in metastatic colorectal cancer with wild-type KRAS. PMID: 24500024 Ref: Can we accurately report PTEN status in advanced colorectal cancer? PMID: 24564252 Ref: Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review. PMID: 24587660 Ref: EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. PMID: 24595598 Ref: The clinical implication of cancer-associated microvasculature and fibroblast in advanced colorectal cancer patients with synchronous or metachronous metastases. PMID: 24642707 Ref: PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: two hits on the gene? PMID: 24647592 Ref: Aged black garlic extract inhibits HT29 colon cancer cell growth via the PI3K/Akt signaling pathway. PMID: 24649105 Ref: Quantitatively controlling expression of miR-17~92 determines colon tumor progression in a mouse tumor model. PMID: 24681249 Ref: The roles of miR-200c in colon cancer and associated molecular mechanisms. PMID: 24682933 Ref: miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway. PMID: 24685694 Ref: EGR1-dependent PTEN upregulation by 2-benzoyloxycinnamaldehyde attenuates cell invasion and EMT in colon cancer. PMID: 24704156 Ref: MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. PMID: 24735923 Ref: The PTEN/PI3K/Akt and Wnt/beta-catenin signaling pathways are involved in the inhibitory effect of resveratrol on human colon cancer cell proliferation. PMID: 24756222 Ref: The Emerging Role of NRAS Mutations in Colorectal Cancer Patients Selected for Anti-EGFR Therapies. PMID: 24758538 Ref: Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages. PMID: 24780321 Ref: MicroRNA-103 promotes colorectal cancer by targeting tumor suppressor DICER and PTEN. PMID: 24828205 Ref: MicroRNA-21 promotes tumour malignancy via increased nuclear translocation of beta-catenin and predicts poor outcome in APC-mutated but not in APC-wild-type colorectal cancer. PMID: 24832083 Ref: Impact of genetic profiles on the efficacy of anti-EGFR antibodies in metastatic colorectal cancer with KRAS mutation. PMID: 24839940 Ref: NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. PMID: 24862762 Ref: The prognostic value of the Na(+)/ H(+) exchanger regulatory factor 1 (NHERF1) protein in cancer. PMID: 24878819 Ref: MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression. PMID: 24912422 Ref: WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear beta-Catenin depend on active PI3K signaling. PMID: 24930890 Ref: The association of phosphatase and tensin homolog deleted on chromosome 10 polymorphisms and lifestyle habits with colorectal cancer risk in a Chinese population. PMID: 24935469 Ref: Influence of CHIEF pathway genes on gene expression: a pathway approach to functionality. PMID: 24959314 Ref: Current approaches for predicting a lack of response to anti-EGFR therapy in KRAS wild-type patients. PMID: 25032217 Ref: Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition. PMID: 25053989 Ref: Utilization and costs of home care for patients with colorectal cancer: a population-based study. PMID: 25077120 Ref: The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor. PMID: 25107843 Ref: Beyond KRAS: Predictive factors of the efficacy of anti-EGFR monoclonal antibodies in the treatment of metastatic colorectal cancer. PMID: 25110411 Ref: Cowden syndrome: what oncology nurses need to know about increased risk of developing certain cancers. PMID: 25158662 Ref: Omega-3 fatty acid is a potential preventive agent for recurrent colon cancer. PMID: 25193342 Ref: Concomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer. PMID: 25202365 Ref: miR494 is an independent prognostic factor and promotes cell migration and invasion in colorectal cancer by directly targeting PTEN. PMID: 25270723 Ref: Silence of PTEN in colorectal cancer cells via siRNA inhibits cell growth. PMID: 25272061 Ref: Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis. PMID: 25395662 Ref: Conversion Therapy Using mFOLFOX6 With Panitumumab for Unresectable Liver Metastases From Multiple Colorectal Cancers With Familial Adenomatous Polyposis. PMID: 25437589 Ref: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. PMID: 25443414 Ref: CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas. PMID: 25484061 |
Ref: An exploratory biomarker study in metastatic tumors from colorectal cancer patients treated with bevacizumab. PMID: 24980447 Ref: Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions. PMID: 25238946 Ref: Overexpression of ribonuclease inhibitor defines good prognosis and suppresses proliferation and metastasis in human colorectal cancer cells via PI3K/AKT pathway. PMID: 25257839 Ref: Updated guidelines for biomarker testing in colorectal carcinoma: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology. PMID: 25373533 Ref: Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition. PMID: 25388513 Ref: Portrait of the PI3K/AKT pathway in colorectal cancer. PMID: 25450577 Ref: MiR-92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway. PMID: 25515201 Ref: Catechol-O-methyltransferase inhibits colorectal cancer cell proliferation and invasion. PMID: 25532943 Ref: Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. PMID: 25547115 Ref: Cathelicidin, an antimicrobial peptide produced by macrophages, promotes colon cancer by activating the Wnt/beta-catenin pathway. PMID: 25596747 Ref: MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation. PMID: 25603978 Ref: A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas. PMID: 25617745 Ref: PTEN deletion potentiates invasion of colorectal cancer spheroidal cells through 3D Matrigel. PMID: 25625883 Ref: Non-enzymatic action of RRM1 protein upregulates PTEN leading to inhibition of colorectal cancer metastasis. PMID: 25638032 Ref: Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases. PMID: 25639985 Ref: Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer. PMID: 25644785 Ref: MiR-32 induces cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting PTEN. PMID: 25647261 Ref: Effects of PTEN on the proliferation and apoptosis of colorectal cancer cells via the phosphoinositol-3-kinase/Akt pathway. PMID: 25683168 Ref: Novel molecular insights from routine genotyping of colorectal carcinomas. PMID: 25683705 Ref: Cyclin-dependent kinase pathway aberrations in diverse malignancies: clinical and molecular characteristics. PMID: 25695927 Ref: Evaluating patient-derived colorectal cancer xenografts as preclinical models by comparison with patient clinical data. PMID: 25712343 Ref: AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants. PMID: 25714871 Ref: Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies. PMID: 25773992 Ref: Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer. PMID: 25786087 Ref: Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer. PMID: 25826503 Ref: Colorectal cancer risk in hamartomatous polyposis syndromes. PMID: 25848489 Ref: Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-kappaB Pathway. PMID: 25873394 Ref: Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms. PMID: 25886453 Ref: Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers. PMID: 25920435 Ref: A specific KRAS codon 13 mutation is an independent predictor for colorectal cancer metachronous distant metastases. PMID: 25973306 Ref: A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancer. PMID: 25986931 Ref: Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy. PMID: 26027741 Ref: Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells. PMID: 26045985 Ref: MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice. PMID: 26055138 Ref: MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer. PMID: 26064956 Ref: A Transition Zone Showing Highly Discontinuous or Alternating Levels of Stem Cell and Proliferation Markers Characterizes the Development of PTEN-Haploinsufficient Colorectal Cancer. PMID: 26098881 Ref: Assessment of the In Vivo Activity of PI3K and MEK Inhibitors in Genetically Defined Models of Colorectal Cancer. PMID: 26206338 Ref: Calycosin induces apoptosis by the regulation of ERbeta/miR-17 signaling pathway in human colorectal cancer cells. PMID: 26215320 Ref: Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach. PMID: 26227479 Ref: Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells. PMID: 26236156 Ref: Molecular biomarkers in colorectal carcinoma. PMID: 26237292 Ref: MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. PMID: 26238857 Ref: High expression of COUP-TF II cooperated with negative Smad4 expression predicts poor prognosis in patients with colorectal cancer. PMID: 26261604 Ref: Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice. PMID: 26262998 Ref: MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer. PMID: 26272063 Ref: Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer. PMID: 26392102 Ref: PTEN regulates RPA1 and protects DNA replication forks. PMID: 26403191 Ref: Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3beta pathway in human colon cancer. PMID: 26452029 Ref: Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PMID: 26469692 Ref: Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PMID: 26492315 Ref: Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. PMID: 26506839 Ref: Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients. PMID: 26508446 Ref: Mutational profiling of colorectal cancers with microsatellite instability. PMID: 26517354 Ref: Tissue-Specific Effects of Reduced beta-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. PMID: 26528816 Ref: Roles of genetic variants in the PI3K/PTEN pathways in susceptibility to colorectal carcinoma and clinical outcomes treated with FOLFOX regimen. PMID: 26722535 Ref: Changes in immunoexpression of p53, Ki-67, Ets-1, APAF-1 and PTEN in serrated and conventional colon adenomas. PMID: 26743285 Ref: Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways. PMID: 26770191 Ref: Small-area variation in screening for cancer, glucose and cholesterol in Ontario: a cross-sectional study. PMID: 26835437 Ref: Association of genetic polymorphisms in PTEN and additional interaction with alcohol consumption and smoking on colorectal cancer in Chinese population. PMID: 26885116 |
Ref: PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells. PMID: 26224641 Ref: Pre-trial inter-laboratory analytical validation of the FOCUS4 personalised therapy trial. PMID: 26350752 Ref: Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of Colorectal Carcinoma Without Distant Metastasis. PMID: 26471487 Ref: KRAS mutation in lung metastases from colorectal cancer: prognostic implications. PMID: 26715198 Ref: Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. PMID: 26750720 Ref: The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylation. PMID: 26787105 Ref: Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. PMID: 26797410 Ref: Biomarkers predicting resistance to epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer with wild-type KRAS. PMID: 26869800 Ref: Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment. PMID: 26909603 Ref: Physcion 8-O-beta-glucopyranoside prevents hypoxia-induced epithelial-mesenchymal transition in colorectal cancer HCT116 cells by modulating EMMPRIN. PMID: 26925795 Ref: Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. PMID: 26983878 Ref: DDX3 enhances oncogenic KRASinduced tumor invasion in colorectal cancer via the betacatenin/ZEB1 axis. PMID: 27007150 Ref: A novel quantitative method of pten expression assessment in tumor tissue. PMID: 27049078 Ref: Establishment and characterization of HROC69 - a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft. PMID: 27087592 Ref: Allelic loss at PTEN locus leads to progression of colorectal carcinoma among North Indian patients. PMID: 27098297 Ref: Oridonin upregulates PTEN through activating p38 MAPK and inhibits proliferation in human colon cancer cells. PMID: 27108927 Ref: Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype. PMID: 27119498 Ref: Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples. PMID: 27146902 Ref: An unusual case of Cowden syndrome associated with ganglioneuromatous polyposis. PMID: 27168869 Ref: Growth hormone is permissive for neoplastic colon growth. PMID: 27226307 Ref: The Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal Cancer. PMID: 27242542 Ref: IL-1beta/NF-kb signaling promotes colorectal cancer cell growth through miR-181a/PTEN axis. PMID: 27264420 Ref: PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study. PMID: 27296289 Ref: Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors With 2 or More Somatic Mutations in Mismatch Repair Genes. PMID: 27302833 Ref: MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer. PMID: 27350731 Ref: DNA methylation based biomarkers in colorectal cancer: A systematic review. PMID: 27385266 Ref: In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity. PMID: 27392434 Ref: Crocodile blood extract induces the apoptosis of lung cancer cells through PTEN activity. PMID: 27431918 Ref: Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development. PMID: 27460083 Ref: Lentivirus-mediated shRNA interference of ghrelin receptor blocks proliferation in the colorectal cancer cells. PMID: 27464938 Ref: Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations. PMID: 27499925 Ref: Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer. PMID: 27543779 Ref: MiR-29a Regulates Radiosensitivity in Human Intestinal Cells by Targeting PTEN Gene. PMID: 27548517 Ref: NHERF1/EBP50 Suppresses Wnt-beta-Catenin Pathway-Driven Intestinal Neoplasia. PMID: 27566107 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy. PMID: 27570430 Ref: Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition. PMID: 27622019 Ref: Telomere Length, TERT, and miRNA Expression. PMID: 27627813 Ref: MEK Inhibitor Suppresses Expression of the miR-17-92 Cluster with G1-Phase Arrest in HT-29 Human Colon Cancer Cells and MIA PaCa-2 Pancreatic Cancer Cells. PMID: 27630293 Ref: Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer. PMID: 27661110 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer. PMID: 27682134 Ref: Odontogenic ameloblast-associated protein (ODAM) inhibits human colorectal cancer growth by promoting PTEN elevation and inactivating PI3K/AKT signaling. PMID: 27694004 Ref: Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation. PMID: 27716613 Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. PMID: 27756406 Ref: Subcellular protein expression models for microsatellite instability in colorectal adenocarcinoma tissue images. PMID: 27770786 Ref: Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer. PMID: 27777877 Ref: Functional exploration of colorectal cancer genomes using Drosophila. PMID: 27897178 Ref: MiR-200a acts as an oncogene in colorectal carcinoma by targeting PTEN. PMID: 27983967 Ref: [A Case of Metastatic Colon Cancer Dramatically Affected by Anti-EGFR Antibody Therapy]. PMID: 28133136 |
Ref: Breast cancer risk and clinical implications for germline PTEN mutation carriers. PMID: 26700035 Ref: Dysregulation of MicroRNA-543 expression in colorectal cancer promotes tumor migration and invasion. PMID: 27148794 Ref: Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition. PMID: 27375020 Ref: Gastrointestinal Polyposis in Cowden Syndrome. PMID: 27661969 Ref: Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells. PMID: 27902968 Ref: Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue. PMID: 28061442 Ref: Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. PMID: 28082369 Ref: Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. PMID: 28106826 Ref: QMC-PCRx: a novel method for rapid mutation detection. PMID: 28153952 Ref: Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer. PMID: 28178391 Ref: TGF-beta1/PTEN/PI3K signaling plays a critical role in the anti-proliferation effect of tetrandrine in human colon cancer cells. PMID: 28197642 Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: STAT1 Inhibits MiR-181a Expression to Suppress Colorectal Cancer Cell Proliferation Through PTEN/Akt. PMID: 28322462 Ref: Increased phosphorylation of 4Ebinding protein 1 predicts poor prognosis for patients with colorectal cancer. PMID: 28339030 Ref: Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis. PMID: 28351943 Ref: [Expression characteristics of PTEN and NDRG1 in colorectal carcinoma and their prognostic value]. PMID: 28376589 Ref: Establishment of apoptotic regulatory network for genetic markers of colorectal cancer. PMID: 28386169 Ref: Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. PMID: 28386190 Ref: A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells. PMID: 28388571 Ref: MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop. PMID: 28422727 Ref: Risk factors for brain metastases in patients with metastatic colorectal cancer. PMID: 28447565 Ref: Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. PMID: 28454566 Ref: A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer). PMID: 28460341 Ref: [Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis]. PMID: 28474162 Ref: Clinical Implications for Germline PTEN Spectrum Disorders. PMID: 28476234 Ref: [MiR-145 inhibits drug resistance to Oxaliplatin in colorectal cancer cells through regulating G protein coupled receptor 98]. PMID: 28534337 Ref: Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells. PMID: 28534975 Ref: The novel hypoxia-inducible factor-1alpha inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. PMID: 28569777 Ref: Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer. PMID: 28678173 Ref: Haploinsufficient tumor suppressor genes. PMID: 28680740 Ref: Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody. PMID: 28685087 Ref: MicroRNA-582 promotes tumorigenesis by targeting phosphatase and tensin homologue in colorectal cancer. PMID: 28713947 Ref: PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity. PMID: 28729699 Ref: M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway. PMID: 28751160 Ref: A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis. PMID: 28775144 Ref: The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN. PMID: 28779166 Ref: Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-kappaB/AKT/PTEN/MAPK pathways. PMID: 28821160 Ref: Involvement of miR-155/FOXO3a and miR-222/PTEN in acquired radioresistance of colorectal cancer cell line. PMID: 28879560 Ref: Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells. PMID: 28888100 Ref: EGFR pathway subgroups in Chilean colorectal cancer patients, detected by mutational and expression profiles, associated to different clinicopathological features. PMID: 28936923 Ref: High mRNA expression of splice variant SYK short correlates with hepatic disease progression in chemonaive lymph node negative colon cancer patients. PMID: 28957395 Ref: MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer. PMID: 28957811 Ref: TUSC7 acts as a tumor suppressor in colorectal cancer. PMID: 28979678 Ref: Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b. PMID: 29036788 Ref: MicroRNA760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1mediated PTEN/AKT signalling pathway. PMID: 29039575 Ref: [Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN]. PMID: 29082697 Ref: Tumor-biopsy stratification based on mTOR-pathway activity and functional mutations in the upstream genes PIK3CA and PTEN. PMID: 29137436 Ref: Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells. PMID: 29160412 Ref: Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer. PMID: 29212173 Ref: miRNA-495 suppresses proliferation and migration of colorectal cancer cells by targeting FAM83D. PMID: 29221726 Ref: Targeted next generation sequencing in Chinese colorectal cancer patients guided anti-EGFR treatment and facilitated precision cancer medicine. PMID: 29285234 Ref: Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein. PMID: 29551923 |
Ref: The Effect of miR-200c Inhibition on Chemosensitivity (5- FluoroUracil) in Colorectal Cancer. PMID: 28411308 Ref: Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-beta/PI3K-AKT-mTOR signaling pathway. PMID: 28884839 Ref: AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. PMID: 28967905 Ref: Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. PMID: 29115462 Ref: Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience. PMID: 29128266 Ref: MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A. PMID: 29160937 Ref: Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes. PMID: 29180604 Ref: A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. PMID: 29194591 Ref: Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 29328495 Ref: A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer. PMID: 29329541 Ref: TEMPORARY REMOVAL: Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway. PMID: 29339153 Ref: Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies. PMID: 29422975 Ref: DKK2 imparts tumor immunity evasion through beta-catenin-independent suppression of cytotoxic immune-cell activation. PMID: 29431745 Ref: mir-106a regulates cell proliferation and apoptosis of colon cancer cells through targeting the PTEN/PI3K/AKT signaling pathway. PMID: 29435057 Ref: Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: a report of two instructive cases. PMID: 29438965 Ref: High expression of DJ-1 promotes growth and invasion via the PTEN-AKT pathway and predicts a poor prognosis in colorectal cancer. PMID: 29441725 Ref: Combination of Kras activation and PTEN deletion contributes to murine hepatopancreatic ductal malignancy. PMID: 29452147 Ref: High expression of WWP1 predicts poor prognosis and associates with tumor progression in human colorectal cancer. PMID: 29511596 Ref: Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN. PMID: 29530061 Ref: BRAF and EGFR inhibitors synergize to increase cytotoxic effects and decrease stem cell capacities in BRAF(V600E)-mutant colorectal cancer cells. PMID: 29534162 Ref: A non-canonical tumor suppressive role for the long non-coding RNA MALAT1 in colon and breast cancers. PMID: 29574704 Ref: Racial Disparities in the Molecular Landscape of Cancer. PMID: 29599344 Ref: [Prediction of EGFR blockade responses in metastatic colorectal carcinoma]. PMID: 29631407 Ref: Nanoencapsulation of Novel Inhibitors of PNKP for Selective Sensitization to Ionizing Radiation and Irinotecan and Induction of Synthetic Lethality. PMID: 29688721 Ref: Population-based statistical inference for temporal sequence of somatic mutations in cancer genomes. PMID: 29697365 Ref: Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells. PMID: 29731993 Ref: Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer. PMID: 29770434 Ref: Primary tumor sidedness is an independent prognostic marker for survival in metastatic colorectal cancer: Results from a large retrospective cohort with mutational analysis. PMID: 29771009 Ref: Massively parallel sequencing analysis of mucinous ovarian carcinomas: genomic profiling and differential diagnoses. PMID: 29793804 Ref: Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis. PMID: 29867200 Ref: Upregulation of HOXA10 Protein Expression Predicts Poor Prognosis for Colorectal Cancer. PMID: 29870276 Ref: Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells. PMID: 29921474 Ref: Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling. PMID: 29957460 Ref: Optimization of the diagnosis of inherited colorectal cancer using NGS and capture of exonic and intronic sequences of panel genes. PMID: 29967336 Ref: Differences in gene mutations according to gender among patients with colorectal cancer. PMID: 29976257 Ref: Colorectal Cancer Stratification in the Routine Clinical Pathway: A District General Hospital Experience. PMID: 29985199 Ref: miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3beta and Wnt/beta-catenin signaling pathways. PMID: 30013659 Ref: Sirt3-mediated mitochondrial fission regulates the colorectal cancer stress response by modulating the Akt/PTEN signalling pathway. PMID: 30021354 Ref: Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1alpha mediated signal pathway. PMID: 30036603 Ref: Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation. PMID: 30045022 Ref: High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway. PMID: 30064475 Ref: Molecular characteristics of colorectal cancer in a Middle Eastern population in a single institution. PMID: 30078023 Ref: PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A. PMID: 30118842 Ref: MiR-92a promotes tumorigenesis of colorectal cancer, a transcriptomic and functional based study. PMID: 30119209 Ref: LINC00312 represses proliferation and metastasis of colorectal cancer cells by regulation of miR-21. PMID: 30134003 Ref: Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog. PMID: 30186399 Ref: Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition. PMID: 30201826 Ref: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases. PMID: 30202242 Ref: Tumor suppressive function of E2F-1 on PTEN-induced serrated colorectal carcinogenesis. PMID: 30206933 Ref: Down-regulation of miR-29a facilitates apoptosis of colorectal carcinoma cell SW480 and suppresses its Paclitaxel resistance. PMID: 30229821 Ref: F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway. PMID: 30257389 Ref: Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten-deficient mice. PMID: 30292635 Ref: Boosting care and knowledge about hereditary cancer: European Reference Network on Genetic Tumour Risk Syndromes. PMID: 30302652 Ref: Effects of Lactobacillus acidophilus and Bifidobacterium bifidum Probiotics on the Expression of MicroRNAs 135b, 26b, 18a and 155, and Their Involving Genes in Mice Colon Cancer. PMID: 30311185 Ref: Microcystin-LR promotes migration via the cooperation between microRNA-221/PTEN and STAT3 signal pathway in colon cancer cell line DLD-1. PMID: 30312888 Ref: Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective. PMID: 30317621 Ref: Doxorubicin resistance induces IL6 activation in the colon cancer cell line LS180. PMID: 30344742 |