Primary Site >> Biliary tract Cancer
Gene >> PTEN
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Ref: Allelotype analysis of the PTEN, Smad4 and DCC genes in biliary tract cancer. PMID: 12168833 |
Ref: Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis. PMID: 12668978 |
Ref: [Expression and significance of PTEN and nm23 in the metastasis of gallbladder cancer]. PMID: 15875318 |
Ref: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. PMID: 16767220 |
Ref: Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. PMID: 18158568 |
Ref: Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma. PMID: 18677542 |
Ref: The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma. PMID: 19147772 |
Ref: Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression. PMID: 21354147 Ref: CpG-island methylation study of liver fluke-related cholangiocarcinoma. PMID: 21448164 Ref: Overexpression of EZH2 and loss of expression of PTEN is associated with invasion, metastasis, and poor progression of gallbladder adenocarcinoma. PMID: 21719208 |
Ref: The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. PMID: 21874010 Ref: Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. PMID: 22180306 Ref: Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability. PMID: 22762308 Ref: PTEN and PDCD4 are bona fide targets of microRNA-21 in human cholangiocarcinoma. PMID: 22770403 |
Ref: Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21. PMID: 22213145 Ref: Akt and mTORC1 have different roles during liver tumorigenesis in mice. PMID: 23376645 Ref: PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. PMID: 23483557 Ref: Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. PMID: 23832540 Ref: NAFLD, NASH and liver cancer. PMID: 24080776 Ref: Role of aquaporin-5 in gallbladder carcinoma. PMID: 24217644 |
Ref: GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. PMID: 24141775 Ref: High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases. PMID: 24186137 Ref: Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels. PMID: 24186143 Ref: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. PMID: 24563076 Ref: Role of aberrant PI3K pathway activation in gallbladder tumorigenesis. PMID: 24658595 Ref: Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma. PMID: 24796583 Ref: Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets. PMID: 24889489 Ref: miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator. PMID: 25239565 Ref: Mutational landscape of intrahepatic cholangiocarcinoma. PMID: 25526346 |
Ref: Downregulation of TPTE2P1 Inhibits Migration and Invasion of Gallbladder Cancer Cells. PMID: 25676706 Ref: miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. PMID: 25769721 Ref: MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN. PMID: 25803229 Ref: Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer. PMID: 26294099 Ref: miR-221 Promotes Epithelial-Mesenchymal Transition through Targeting PTEN and Forms a Positive Feedback Loop with beta-catenin/c-Jun Signaling Pathway in Extra-Hepatic Cholangiocarcinoma. PMID: 26501139 Ref: CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice. PMID: 26508638 Ref: Effects of PTEN gene alteration in patients with gallbladder cancer. PMID: 26586294 |
Ref: Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets. PMID: 26500333 Ref: Epithelial Transforming Growth Factor-beta Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma. PMID: 26627606 Ref: CD133 promotes gallbladder carcinoma cell migration through activating Akt phosphorylation. PMID: 26910892 Ref: A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion. PMID: 27032374 Ref: Knockdown of Sall4 inhibits intrahepatic cholangiocarcinoma cell migration and invasion in ICC-9810 cells. PMID: 27601921 |
Ref: Corrigendum: A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion. PMID: 28045050 Ref: Epigenetic Downregulation of PTEN in Gallbladder Cancer. PMID: 28124240 Ref: TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. PMID: 28423362 Ref: K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines. PMID: 28544747 Ref: Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components. PMID: 28698100 |
Ref: Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway. PMID: 29170841 Ref: Genotyping and mRNA profiling reveal actionable molecular targets in biliary tract cancers. PMID: 29416916 Ref: Combination of Kras activation and PTEN deletion contributes to murine hepatopancreatic ductal malignancy. PMID: 29452147 Ref: Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma. PMID: 29740198 Ref: Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer. PMID: 29785570 Ref: Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer. PMID: 30282449 Ref: The chemosensory function of primary cilia regulates cholangiocyte migration, invasion and tumor growth. PMID: 30299561 |