Primary Site >> Colorectal Cancer
Gene >> PTCH1
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Ref: Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. PMID: 9192811 |
Ref: The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations. PMID: 10505029 Ref: A novel sensitive method to detect frameshift mutations in exonic repeat sequences of cancer-related genes. PMID: 10545425 |
Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 |
Ref: Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. PMID: 15258993 |
Ref: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. PMID: 15645142 |
Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 |
Ref: Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas. PMID: 17461467 Ref: Hedgehog signaling pathway is inactive in colorectal cancer cell lines. PMID: 17683069 |
Ref: Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation. PMID: 19280222 Ref: Sonic hedgehog relates to colorectal carcinogenesis. PMID: 19662327 |
Ref: PTCH1, a receptor of Hedgehog signaling pathway, is correlated with metastatic potential of colorectal cancer. PMID: 20230186 |
Ref: Downregulation of the hedgehog receptor PTCH1 in colorectal serrated adenocarcinomas is not caused by PTCH1 mutations. PMID: 21234763 Ref: Differential expression profiles of the Hedgehog signaling pathway between microsatellite-stable and microsatellite-unstable colorectal cancers. PMID: 21725600 Ref: A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22. PMID: 21811255 Ref: The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. PMID: 21860067 Ref: Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro. PMID: 21940310 |
Ref: Silencing of CCDC6 reduces the expression of 14-3-3sigma in colorectal carcinoma cells. PMID: 22399611 Ref: Expression of smoothened protein in colon cancer and its prognostic value for postoperative liver metastasis. PMID: 23098507 |
Ref: Aberrant methylation of the PTCH1 gene promoter region in aberrant crypt foci. PMID: 22945423 Ref: Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli. PMID: 23551431 Ref: A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis. PMID: 24368541 |
Ref: Distinct profile of HIF1alpha, PTCH, EphB2, or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma. PMID: 24612059 Ref: Hedgehog-glioma-associated oncogene homolog-1 signaling in colon cancer cells and its role in the celecoxib-mediated anti-cancer effect. PMID: 25295109 |
Ref: Biomarkers for the identification of precursor polyps of colorectal serrated adenocarcinomas. PMID: 26832730 Ref: The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells. PMID: 27917272 |
Ref: Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1. PMID: 28539123 Ref: FOXR2 Promotes the Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells. PMID: 28548041 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells. PMID: 29212028 Ref: SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer. PMID: 29456503 |
Ref: A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. PMID: 29194591 Ref: Two novel colorectal cancer risk loci in the region on chromosome 9q22.32. PMID: 29541405 |