Primary Site >> Colorectal Cancer
Gene >> PRRT2
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Ref: Studies on protein kinase C and colon carcinogenesis. PMID: 3689124 |
Ref: Changes in glycosaminoglycan sulfation and protein kinase C subcellular distribution during differentiation of the human colon tumor cell line Caco-2. PMID: 2737267 |
Ref: Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression. PMID: 2388620 |
Ref: Decreased levels of protein kinase C enzyme activity and protein kinase C mRNA in primary colon tumors. PMID: 8404381 Ref: Effect of staurosporine on suppression of heat shock gene expression and thermotolerance development in HT-29 cells. PMID: 8512574 |
Ref: Regulation of protein kinase C and role in cancer biology. PMID: 7712599 Ref: Effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on HSP70 and HSP28 gene expression and thermotolerance development in human colon carcinoma cells. PMID: 7802695 Ref: The enterocyte-like differentiation of the Caco-2 tumor cell line strongly correlates with responsiveness to cAMP and activation of kinase A pathway. PMID: 7819134 Ref: Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors. PMID: 7999261 Ref: Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells. PMID: 8053934 Ref: Protein kinase C activity as a potential marker for colorectal neoplasia. PMID: 8131680 Ref: Antipeptide antibodies directed against the C-terminus of protein kinase C zeta (PKC zeta) react with a Ca(2+)- and TPA-sensitive PKC in HT-29 human intestinal epithelial cells. PMID: 8187876 |
Ref: Differential expression of protein kinase C isoforms in human colorectal cancers. PMID: 7861778 Ref: The tumor promoter receptor protein kinase C: a novel target for chemoprevention and therapy of human colon cancer. PMID: 8532710 |
Ref: MAPK activity is down-regulated in human colon adenocarcinoma: correlation with PKC activity. PMID: 8615643 Ref: Diet intervention for modifying cancer risk. PMID: 8895992 Ref: Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells. PMID: 8913270 Ref: Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control. PMID: 8964400 |
Ref: Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-alpha (PKC-alpha) pseudosubstrate peptides through a P-glycoprotein-independent mechanism. PMID: 9547673 Ref: Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells. PMID: 12503187 |
Ref: Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. PMID: 11245437 Ref: Expression of protein kinase C beta1 confers resistance to TNFalpha- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells. PMID: 11410863 |
Ref: Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells. PMID: 12203364 |
Ref: Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles. PMID: 12966098 |
Ref: Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells. PMID: 15304500 Ref: Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity. PMID: 15491978 Ref: Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals. PMID: 15548175 |
Ref: [Target lethal effect of recombinant soluble Fas coupled with protein kinase C inhibitor on colorectal carcinoma cells]. PMID: 16886117 |
Ref: Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells. PMID: 19034280 |
Ref: Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer. PMID: 19277684 Ref: Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers. PMID: 19506549 |
Ref: Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. PMID: 21961726 |
Ref: Par-complex aPKC and Par3 cross-talk with innate immunity NF-kappaB pathway in epithelial cells. PMID: 24244864 |
Ref: Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. PMID: 25619690 |
Ref: Regulation of protein kinase CK2 catalytic activity by protein kinase C and phospholipase D2. PMID: 26703243 |
Ref: A mononucleotide repeat in PRRT2 is an important, frequent target of mismatch repair deficiency in cancer. PMID: 27907910 Ref: Clinicopathological characteristics of KIT and protein kinase C-delta expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour. PMID: 28561935 |
Ref: Discovery of a small-molecule protein kinase Cdelta-selective activator with promising application in colon cancer therapy. PMID: 29348560 Ref: Protein Kinase C-zeta stimulates colorectal cancer cell carcinogenesis via PKC-zeta/Rac1/Pak1/beta-Catenin signaling cascade. PMID: 29408512 |