Primary Site >> Colorectal Cancer
Gene >> PRKDC
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Ref: Importance of glutathione and associated enzymes in drug response. PMID: 9406235 |
Ref: High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. PMID: 11532879 Ref: Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis. PMID: 11731412 |
Ref: Expression of the DNA-PK binding protein E4-34K fails to confer radiation sensitivity to mammalian cells. PMID: 12556331 |
Ref: Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. PMID: 15254745 |
Ref: Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions. PMID: 17234773 |
Ref: Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli. PMID: 18454178 Ref: [Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]. PMID: 19080428 |
Ref: Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice. PMID: 19194513 |
Ref: Expression profile of significant immortalization genes in colon cancer. PMID: 20127035 Ref: Radiation-induced survivin nuclear accumulation is linked to DNA damage repair. PMID: 20394854 |
Ref: Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts. PMID: 21567080 |
Ref: Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells. PMID: 21221710 Ref: Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. PMID: 22189105 Ref: Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. PMID: 22576130 Ref: Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA. PMID: 22924158 |
Ref: Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1. PMID: 23325550 Ref: Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer. PMID: 23603433 |
Ref: The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines. PMID: 24338765 Ref: Characterization of EBV-related lymphoproliferative lesions arising in donor lymphocytes of transplanted human tumor tissues in the NOG mouse. PMID: 25077758 |
Ref: The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice. PMID: 25740629 Ref: DNA-PKcs interference sensitizes colorectal cancer cells to a mTOR kinase inhibitor WAY-600. PMID: 26381179 |
Ref: Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells. PMID: 26992638 |
Ref: Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. PMID: 28035050 |
Ref: Using patient-derived xenograft models of colorectal liver metastases to predict chemosensitivity. PMID: 29804848 Ref: Copy number variation analysis and targeted NGS in 77 families with suspected Lynch syndrome reveals novel potential causative genes. PMID: 29987844 Ref: Keratin 80 promotes migration and invasion of colorectal carcinoma by interacting with PRKDC via activating the AKT pathway. PMID: 30262880 |