Primary Site >> Colorectal Cancer
Gene >> PPM1D
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Ref: MRNA expression of genes altered by 5-azacytidine treatment in cancer cell lines is associated with clinicopathological parameters of human cancers. PMID: 11768609 |
Ref: The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. PMID: 16936775 Ref: Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine. PMID: 18371349 |
Ref: p53 Regulates LIF expression in human medulloblastoma cells. PMID: 19907922 |
Ref: p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors. PMID: 22405851 |
Ref: Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. PMID: 23649806 Ref: Expression and significance of the Wip1 proto-oncogene in colorectal cancer. PMID: 23679302 Ref: Knockdown of protein phosphatase magnesium-dependent 1 (PPM1D) through lentivirus-mediated RNA silencing inhibits colorectal carcinoma cell proliferation. PMID: 23745790 |
Ref: PPM1D is a prognostic marker and therapeutic target in colorectal cancer. PMID: 25009596 Ref: Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality. PMID: 25117622 Ref: Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line. PMID: 25466181 |
Ref: Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients. PMID: 25742468 |
Ref: Wip1 gene silencing enhances the chemosensitivity of human colon cancer cells. PMID: 28781635 |
Ref: NF-kappaB-induced WIP1 expression promotes colorectal cancer cell proliferation through mTOR signaling. PMID: 29367109 |