Primary Site >> Colorectal Cancer
Gene >> PPARG
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. PMID: 9472692 Ref: PPARgamma and colorectal carcinoma: conflicts in a nuclear family. PMID: 9734386 Ref: Differentiation and reversal of malignant changes in colon cancer through PPARgamma. PMID: 9734398 Ref: Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. PMID: 9734399 Ref: Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells. PMID: 9797355 |
Ref: Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer. PMID: 10706135 Ref: Peroxisome proliferator-activated receptors in tumorigenesis: targets of tumour promotion and treatment. PMID: 10947870 Ref: Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer. PMID: 10984506 Ref: Expression of peroxisome proliferator-activated receptor (PPAR)gamma in gastric cancer and inhibitory effects of PPARgamma agonists. PMID: 11044367 Ref: Preparation and evaluation of o/w type emulsions containing antitumor prostaglandin. PMID: 11104898 |
Ref: Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. PMID: 11289109 Ref: Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats. PMID: 11346461 Ref: Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. PMID: 11378386 Ref: Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells. PMID: 11397807 Ref: Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. PMID: 11412039 Ref: Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies. PMID: 11431375 Ref: 15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway. PMID: 11447213 Ref: Opposite association of two PPARG variants with cancer: overrepresentation of H449H in endometrial carcinoma cases and underrepresentation of P12A in renal cell carcinoma cases. PMID: 11511919 Ref: Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. PMID: 11532858 Ref: Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. PMID: 11713587 |
Ref: Beta-catenin--a linchpin in colorectal carcinogenesis? PMID: 11839557 Ref: Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. PMID: 11950812 Ref: Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene. PMID: 11956653 Ref: Expression of peroxisome proliferator-activated receptors alpha and gamma in differentiating human colon carcinoma Caco-2 cells. PMID: 12000143 Ref: Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. PMID: 12027200 Ref: Butyrate reduces colonic paracellular permeability by enhancing PPARgamma activation. PMID: 12054544 Ref: Controversy: PPARgamma as a target for treatment of colorectal cancer. PMID: 12121872 Ref: Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. PMID: 12189136 Ref: Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer. PMID: 12269390 Ref: APC-dependent suppression of colon carcinogenesis by PPARgamma. PMID: 12370429 Ref: A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. PMID: 12416897 Ref: The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma in indomethacin-Induced apoptosis of colon cancer cells. PMID: 12485869 Ref: Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents. PMID: 12489852 |
Ref: Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice. PMID: 12557142 Ref: Family history of colon cancer: what does it mean and how is it useful? PMID: 12568823 Ref: Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms. PMID: 12591919 Ref: Activation of peroxisome proliferator-activated receptor gamma does not explain the antiproliferative activity of the nonsteroidal anti-inflammatory drug indomethacin on human colorectal cancer cells. PMID: 12606626 Ref: Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. PMID: 12622871 Ref: Polyamines as modifiers of genetic risk factors in human intestinal cancers. PMID: 12653645 Ref: Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. PMID: 12711249 Ref: The antiproliferative effects of PPARgamma ligands in normal human mammary epithelial cells. PMID: 12725418 Ref: Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. PMID: 12813462 Ref: Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. PMID: 12839942 Ref: The role of PPARgamma in colon cancer: is it as simple as APC? PMID: 12891569 Ref: Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines. PMID: 14521714 Ref: Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. PMID: 14522940 Ref: 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway. PMID: 14566836 Ref: Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta. PMID: 14587029 Ref: Hyperlipidic diets induce early alterations of the vitamin A signalling pathway in rat colonic mucosa. PMID: 14986719 Ref: Colonic polyps of acromegalic patients are not associated with mutations of the peroxisome proliferator activated receptor gamma gene. PMID: 15008240 |
Ref: Induction of differentiation and peroxisome proliferator-activated receptor gamma expression in colon cancer cell lines by troglitazone. PMID: 14634802 Ref: Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. PMID: 14662774 Ref: Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1). PMID: 14670614 Ref: Promotion of colon tumors in C57BL/6J-APC(min)/+ mice by thiazolidinedione PPARgamma agonists and a structurally unrelated PPARgamma agonist. PMID: 14713549 Ref: Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells. PMID: 14750214 Ref: PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis. PMID: 15073042 Ref: Limited tumor growth (HT29) in vivo under RO205-2349 is due to increased apoptosis and reduced cell volume but not to decreased proliferation rate. PMID: 15172115 Ref: PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells. PMID: 15177943 Ref: Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. PMID: 15182427 Ref: Colon cancer: genomics and apoptotic events. PMID: 15255176 Ref: Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-g PMID: 15289320 Ref: Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects. PMID: 15289864 Ref: Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases. PMID: 15320743 Ref: 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. PMID: 15342379 Ref: Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells. PMID: 15383218 Ref: Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. PMID: 15535974 Ref: Tocopherols and the treatment of colon cancer. PMID: 15753148 |
Ref: Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR. PMID: 15486348 Ref: The PPAR{gamma} Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas. PMID: 15564289 Ref: Ciglitazone induces early cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells through p65 phosphorylation. PMID: 15618021 Ref: The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells. PMID: 15665104 Ref: Hic-5 regulates an epithelial program mediated by PPARgamma. PMID: 15687259 Ref: Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice. PMID: 15710887 Ref: Alteration of gene expression in macroscopically normal colonic mucosa from individuals with a family history of sporadic colon cancer. PMID: 15746039 Ref: Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation. PMID: 15763423 Ref: 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways. PMID: 15798084 Ref: [The roles of PPARs in digestive diseases]. PMID: 15828235 Ref: A novel peroxisome proliferator-activated receptor gamma isoform with dominant negative activity generated by alternative splicing. PMID: 15857827 Ref: PPARgamma, energy balance, and associations with colon and rectal cancer. PMID: 15860437 Ref: Selective activation of PPARgamma in breast, colon, and lung cancer cell lines. PMID: 15866424 Ref: Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. PMID: 15892897 Ref: Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer. PMID: 15894676 Ref: The PPAR(gamma) K422Q mutation does not contribute to troglitazone inefficiency in colon cancer treatment. PMID: 15911106 Ref: Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway. PMID: 15951157 Ref: Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. PMID: 15961301 Ref: 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal tra PMID: 16077033 Ref: [PPARgamma and colon cancer]. PMID: 16124705 Ref: No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma. PMID: 16141797 Ref: 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-infl PMID: 16155208 |
Ref: PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. PMID: 16215757 Ref: Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. PMID: 16271436 Ref: Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms. PMID: 16303758 Ref: CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation. PMID: 16327995 Ref: Peritoneal metastasis inhibition by linoleic acid with activation of PPARgamma in human gastrointestinal cancer cells. PMID: 16362414 Ref: PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). PMID: 16489531 Ref: Peroxisome proliferator-activated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in Singapore. PMID: 16513680 Ref: Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells. PMID: 16520894 Ref: Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferation. PMID: 16574647 Ref: Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice. PMID: 16606335 Ref: Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice. PMID: 16702308 Ref: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. PMID: 16731769 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. PMID: 16731770 Ref: Inflammation-related gene polymorphisms and colorectal adenoma. PMID: 16775170 Ref: Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism. PMID: 16849586 Ref: Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer. PMID: 16854216 Ref: Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice. PMID: 16858678 Ref: [Effects of peroxisome proliferator-activated receptor-gamma ligand troglitazone on colon cancer cell growth]. PMID: 16892143 Ref: Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines. PMID: 16899971 Ref: PPARgamma is a key target of butyrate-induced caspase-3 activation in the colorectal cancer cell line Caco-2. PMID: 16927016 Ref: Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer. PMID: 16937502 Ref: Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. PMID: 16965392 Ref: Effect of ligand troglitazone on peroxisome proliferator-activated receptor gamma expression and cellular growth in human colon cancer cells. PMID: 17143939 Ref: Peroxisome proliferator-activated receptor gamma is a Zac target gene mediating Zac antiproliferation. PMID: 17178896 |
Ref: Tumour necrosis factor alpha blockade induces an anti-inflammatory growth hormone signalling pathway in experimental colitis. PMID: 16777921 Ref: PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells. PMID: 17096328 Ref: The functional significance of nuclear receptor acetylation. PMID: 17291555 Ref: Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines. PMID: 17389773 Ref: Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner. PMID: 17390024 Ref: Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. PMID: 17442990 Ref: Rosiglitazone enhances fluorouracil-induced apoptosis of HT-29 cells by activating peroxisome proliferator-activated receptor gamma. PMID: 17461445 Ref: 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. PMID: 17462534 Ref: Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. PMID: 17506908 Ref: Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. PMID: 17513608 Ref: De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity. PMID: 17521618 Ref: Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. PMID: 17532820 Ref: Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells. PMID: 17565986 Ref: Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor gamma, in colorectal adenocarcinoma. PMID: 17611675 Ref: Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. PMID: 17632092 Ref: Peroxisome proliferator-activated receptor gamma (PPARgamma) and colorectal carcinogenesis. PMID: 17659359 Ref: 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. PMID: 17707368 Ref: 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. PMID: 17724373 Ref: The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. PMID: 17767717 Ref: Life style-related diseases of the digestive system: colorectal cancer as a life style-related disease: from carcinogenesis to medical treatment. PMID: 17928742 Ref: Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor. PMID: 17952880 Ref: 5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model. PMID: 17975166 Ref: PPARgamma physiology and pathology in gastrointestinal epithelial cells. PMID: 17978568 Ref: Transcriptional upregulation of gastrin in response to peroxisome proliferator-activated receptor gamma agonist triggers cell survival pathways. PMID: 18195488 |
Ref: Influence of peroxisome proliferator-activated receptor (PPAR)gamma Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese. PMID: 17763950 Ref: PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. PMID: 18161004 Ref: PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells. PMID: 18203887 Ref: PPARgamma ligands suppress the feedback loop between E2F2 and cyclin-E1. PMID: 18355447 Ref: Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cells. PMID: 18360708 Ref: Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway. PMID: 18391483 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. PMID: 18460448 Ref: Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. PMID: 18477501 Ref: Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance. PMID: 18507034 Ref: PPARgamma Inhibitors as Novel Tubulin-Targeting Agents. PMID: 18509498 Ref: Synergistic Effects of PPARgamma Ligands and Retinoids in Cancer Treatment. PMID: 18528526 Ref: PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. PMID: 18544567 Ref: The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice. PMID: 18546290 Ref: The Roles of Dietary PPARgamma Ligands for Metastasis in Colorectal Cancer. PMID: 18551182 Ref: Modulation of cell growth and PPARgamma expression in human colorectal cancer cell lines by ciglitazone. PMID: 18579355 Ref: Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. PMID: 18608213 Ref: Pathophysiological Roles of PPARgamma in Gastrointestinal Epithelial Cells. PMID: 18615192 Ref: Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer. PMID: 18645029 Ref: Molecular mechanism of protection against chemically and gamma-radiation induced apoptosis in human colon cancer cells. PMID: 18812638 Ref: 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. PMID: 18852146 Ref: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. PMID: 18992148 Ref: Expression of PPARgamma is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells. PMID: 19020782 Ref: Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the beta-catenin / T cell factor (TCF) pathway in the mouse intestine. PMID: 19075513 Ref: Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis. PMID: 19189639 |
Ref: Gene expression profile in colon cancer cells with respect to XIAP expression status. PMID: 18704457 Ref: Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis. PMID: 19186181 Ref: PPARG: a new independent marker for colorectal cancer survival. PMID: 19236969 Ref: Chemoprevention of colorectal cancer-experimental and clinical aspects-. PMID: 19262006 Ref: Prevention of postoperative infection and micrometastasis by preoperative administration of a PPARgamma agonist following colorectal cancer surgery. PMID: 19305114 Ref: Mesalamine suppresses the expression of TC22, a novel tropomyosin isoform associated with colonic neoplasia. PMID: 19369484 Ref: Dietary modulation of inflammation-induced colorectal cancer through PPARgamma. PMID: 19390648 Ref: Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis. PMID: 19458067 Ref: KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. PMID: 19551868 Ref: Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. PMID: 19638488 Ref: 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. PMID: 19690198 Ref: Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. PMID: 19760027 Ref: Current understanding of the role of PPARgamma in gastrointestinal cancers. PMID: 19884989 Ref: Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo. PMID: 20019843 |
Ref: Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. PMID: 19823826 Ref: PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. PMID: 19912441 Ref: Receptor and enzyme expression for prostanoid metabolism in colorectal cancer related to tumor tissue PGE2. PMID: 20043083 Ref: Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma. PMID: 20089779 Ref: A novel germline mutation in peroxisome proliferator-activated receptor gamma gene associated with large intestine polyp formation and dyslipidemia. PMID: 20123124 Ref: PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. PMID: 20150631 Ref: [PPARgamma agonists for the diseases of gastrointestinal tract and liver]. PMID: 20158102 Ref: [PPARgamma and cancer]. PMID: 20158104 Ref: Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin. PMID: 20372080 Ref: MCC-555-induced NAG-1 expression is mediated in part by KLF4. PMID: 20385121 Ref: Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. PMID: 20485182 Ref: Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease. PMID: 20508519 Ref: RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells. PMID: 20510503 Ref: The role of NF-kappaB and PPARgamma in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors. PMID: 20514536 Ref: Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. PMID: 20540935 Ref: PPARgamma polymorphisms and cancer risk: a meta-analysis involving 32,138 subjects. PMID: 20596649 Ref: PPARgamma Ligand as a Promising Candidate for Colorectal Cancer Chemoprevention: A Pilot Study. PMID: 20814432 Ref: Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor gamma. PMID: 20932931 Ref: Epigenetic silencing of peroxisome proliferator-activated receptor gamma is a biomarker for colorectal cancer progression and adverse patients' outcome. PMID: 21151932 Ref: Peroxisome proliferator activated receptor-gamma and the ubiquitin-proteasome system in colorectal cancer. PMID: 21160623 Ref: Peroxisome proliferator-activated receptor gamma and colorectal cancer. PMID: 21160824 Ref: In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells. PMID: 23136612 |
Ref: Peroxisome-proliferator-activated receptors gamma and beta/delta mediate vascular endothelial growth factor production in colorectal tumor cells. PMID: 20221637 Ref: 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma. PMID: 21544861 Ref: Chemerin, a novel peroxisome proliferator-activated receptor gamma (PPARgamma) target gene that promotes mesenchymal stem cell adipogenesis. PMID: 21572083 Ref: Silencing IL-13Ralpha2 promotes glioblastoma cell death via endogenous signaling. PMID: 21596889 Ref: Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins. PMID: 21819567 Ref: Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. PMID: 21829567 Ref: Expression of PPARgamma and PTEN in human colorectal cancer: An immunohistochemical study using tissue microarray methodology. PMID: 22848291 |
Ref: Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth. PMID: 21412772 Ref: Peroxisome proliferator-activated receptor delta confers resistance to peroxisome proliferator-activated receptor gamma-induced apoptosis in colorectal cancer cells. PMID: 21765467 Ref: Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. PMID: 22109108 Ref: Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. PMID: 22231745 Ref: UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression. PMID: 22286757 Ref: Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer. PMID: 22294764 Ref: COM-1/p8 acts as a tumour growth enhancer in colorectal cancer cell lines. PMID: 22493353 Ref: Rosiglitazone and AS601245 decrease cell adhesion and migration through modulation of specific gene expression in human colon cancer cells. PMID: 22761953 Ref: Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells. PMID: 22771328 Ref: PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis. PMID: 22848209 Ref: Release of cyclic phosphatidic acid from gelatin-based hydrogels inhibit colon cancer cell growth and migration. PMID: 23008752 Ref: Suppressive effect of pioglitazone, a PPAR gamma ligand, on azoxymethane-induced colon aberrant crypt foci in KK-Ay mice. PMID: 23098518 |
Ref: Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARgamma-targeted therapy. PMID: 22543585 Ref: Use of thiazolidinediones and the risk of colorectal cancer in patients with diabetes: a nationwide, population-based, case-control study. PMID: 23043163 Ref: CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARgamma signaling. PMID: 23202735 Ref: Systematic review: diet-gene interactions and the risk of colorectal cancer. PMID: 23216531 Ref: Trans fatty acids affect cellular viability of human intestinal Caco-2 cells and activate peroxisome proliferator-activated receptors. PMID: 23368924 Ref: Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1alpha. PMID: 23368925 Ref: PTB-associated splicing factor (PSF) is a PPARgamma-binding protein and growth regulator of colon cancer cells. PMID: 23516550 Ref: Interplay between SOX9, beta-catenin and PPARgamma activation in colorectal cancer. PMID: 23583560 Ref: 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPARgamma). PMID: 23612072 Ref: SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway. PMID: 23615374 Ref: Deficiency of caveolin-1 in Apc(min/+) mice promotes colorectal tumorigenesis. PMID: 23640045 Ref: The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARgamma. PMID: 23843037 Ref: Tumour-infiltrating CD68+ and CD57+ cells predict patient outcome in stage II-III colorectal cancer. PMID: 23868006 Ref: [The role of TLR4 receptor in development of inflammation and carcinogenesis in ulcerative colitis and pharmacotherapy of this disorder]. PMID: 23905422 Ref: Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice. PMID: 24008356 Ref: MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. PMID: 24027433 Ref: Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk. PMID: 24045924 Ref: omega3-PUFAs exert anti-inflammatory activity in visceral adipocytes from colorectal cancer patients. PMID: 24116229 Ref: Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPARgamma and TNFalpha signaling. PMID: 24133572 Ref: PSF knockdown enhances apoptosis via downregulation of LC3B in human colon cancer cells. PMID: 24288667 Ref: Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population. PMID: 24338422 |
Ref: Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. PMID: 23852449 Ref: Sulindac and Celecoxib regulate cell cycle progression by p53/p21 up regulation to induce apoptosis during initial stages of experimental colorectal cancer. PMID: 23857431 Ref: Peroxisome proliferator-activated receptor gamma ligand troglitazone and TRAIL synergistically induce apoptosis. PMID: 24276615 Ref: Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents. PMID: 24530873 Ref: Association between six genetic polymorphisms and colorectal cancer: a meta-analysis. PMID: 24552298 Ref: Peroxisome proliferator-activated receptor gamma-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer. PMID: 24631504 Ref: WIN induces apoptotic cell death in human colon cancer cells through a block of autophagic flux dependent on PPARgamma down-regulation. PMID: 24696378 Ref: Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/beta-catenin signaling while up-regulating ligand dependent transcription factor PPARgamma. PMID: 24721324 Ref: Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR. PMID: 24729479 Ref: Cladosporol A, a new peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, inhibits colorectal cancer cells proliferation through beta-catenin/TCF pathway inactivation. PMID: 24735796 Ref: Dynamic microbe and molecule networks in a mouse model of colitis-associated colorectal cancer. PMID: 24828543 Ref: A meta-analysis of the association of PPARgamma rs1801282 polymorphism and NSAID usage with the risk of developing cancer. PMID: 24882418 Ref: Emerging role of the beta-catenin-PPARgamma axis in the pathogenesis of colorectal cancer. PMID: 24966585 Ref: A role for peroxisome proliferator-activated receptor gamma in resveratrol-induced colon cancer cell apoptosis. PMID: 24975132 Ref: Structural basis of the transactivation deficiency of the human PPARgamma F360L mutant associated with familial partial lipodystrophy. PMID: 25004973 Ref: Differential cell growth/apoptosis behavior of 13-hydroxyoctadecadienoic acid enantiomers in a colorectal cancer cell line. PMID: 25035111 Ref: Oxaliplatin neurotoxicity involves peroxisome alterations. PPARgamma agonism as preventive pharmacological approach. PMID: 25036594 Ref: Identification of Posttranslational Modifications in Peroxisome Proliferator-Activated Receptor gamma Using Mass Spectrometry. PMID: 25061449 Ref: Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARgamma/OCTN2 pathway. PMID: 25075794 Ref: The mycotoxin patulin decreases expression of density-enhanced phosphatase-1 by down-regulating PPARgamma in human colon cancer cells. PMID: 25098256 Ref: Antiproliferative and apoptotic effects of telmisartan in human colon cancer cells. PMID: 25360175 |
Ref: Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case-control study. PMID: 25488145 Ref: PPARdelta signaling regulates colorectal cancer. PMID: 26004416 Ref: [Curcumin inhibited rat colorectal carcinogenesis by activating PPAR-gamma: an experimental study]. PMID: 26043573 Ref: Effect of Proliferator-Activated Receptor-gamma Pro12Ala Polymorphism on Colorectal Cancer Risk: A Meta-Analysis. PMID: 26049557 Ref: Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and colorectal cancer (CRC) risk. PMID: 26064311 Ref: The PTB-Associated Splicing Factor/Peroxisome Proliferator-Activated Receptor Gamma Axis Regulates Autophagosome Formation in Human Pancreatic Cancer Cells. PMID: 26309807 Ref: Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PMID: 26492315 Ref: Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy. PMID: 26569228 |
Ref: Clinical Significance of Peroxisome Proliferator-Activated Receptor gamma and TRAP220 in Patients with Operable Colorectal Cancer. PMID: 26130665 Ref: L-carnitine ameliorates the liver inflammatory response by regulating carnitine palmitoyltransferase I-dependent PPARgamma signaling. PMID: 26647854 Ref: Chemopreventive action of non-steroidal anti-inflammatory drugs on the inflammatory pathways in colon cancer. PMID: 26898448 Ref: The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARgamma ligands. PMID: 26995279 Ref: Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation. PMID: 27401066 Ref: Aldo-keto reductase 1B10 promotes development of cisplatin resistance in gastrointestinal cancer cells through down-regulating peroxisome proliferator-activated receptor-gamma-dependent mechanism. PMID: 27417252 Ref: Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer. PMID: 27428427 Ref: Glycoprotein screening in colorectal cancer based on differentially expressed Tn antigen. PMID: 27432485 Ref: Phytochemicals Mediate the Expression and Activity of OCTN2 as Activators of the PPARgamma/RXRalpha Pathway. PMID: 27445823 Ref: Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and omega6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells. PMID: 27494857 Ref: Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy. PMID: 27593880 Ref: MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway. PMID: 27783989 |
Ref: Fatty acid-binding protein 1 is preferentially lost in microsatellite instable colorectal carcinomas and is immune modulated via the interferon gamma pathway. PMID: 27687006 Ref: Activation of autophagy and PPARgamma protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: The role of cell differentiation. PMID: 27840291 Ref: Genetic variation in PPARGC1A may affect the role of diet-associated inflammation in colorectal carcinogenesis. PMID: 28051997 Ref: mRNA expression of nuclear factor of activated T-cells, cytoplasmic 2 (NFATc2) and peroxisome proliferator-activated receptor gamma (PPARG) transcription factors in colorectal carcinoma. PMID: 28504924 Ref: 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells. PMID: 28586058 Ref: Identification of Key Genes in Colorectal Cancer Regulated by miR-34a. PMID: 29197895 Ref: Association of PPARG rs 1801282 C>G polymorphism with risk of colorectal cancer: from a case-control study to a meta-analysis. PMID: 29246001 |
Ref: Dihydroartemisinin inhibits colon cancer cell viability by inducing apoptosis through up-regulation of PPARgamma expression. PMID: 29472793 Ref: The impact of polyunsaturated fatty acids on DNA methylation and expression of DNMTs in human colorectal cancer cells. PMID: 29477476 Ref: Peroxisome proliferator-activated receptor gamma coactivator-1alpha is a predictor of lymph node metastasis and poor prognosis in human colorectal cancer. PMID: 29566941 Ref: Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk. PMID: 29802748 Ref: Peroxisome proliferators-activated receptor gamma polymorphisms and colorectal cancer risk. PMID: 29970681 Ref: beta-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC. PMID: 30186819 |