Primary Site >> Colorectal Cancer
Gene >> PPARD
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Ref: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. PMID: 10555149 |
Ref: Peroxisome proliferator-activated receptors in tumorigenesis: targets of tumour promotion and treatment. PMID: 10947870 Ref: Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. PMID: 11087869 Ref: Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma. PMID: 11228540 |
Ref: Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone. PMID: 11304699 Ref: Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. PMID: 11470825 Ref: The molecular basis for prevention of colorectal cancer. PMID: 12445379 |
Ref: Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. PMID: 11756685 |
Ref: Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. PMID: 12702555 |
Ref: Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. PMID: 14976201 Ref: Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. PMID: 15048110 Ref: Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. PMID: 15380519 Ref: WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. PMID: 15539957 Ref: 3-{4-[2-[Benzoxazol-2-yl-methylamino]ethoxy]phenyl}-2-(2-[(18)F]fluoroethoxy)prop ionic acid PMID: 20641433 |
Ref: Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. PMID: 15764152 |
Ref: Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. PMID: 16288226 Ref: Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. PMID: 16293616 Ref: Isoform specific changes in PPAR alpha and beta in colon and breast cancer with differentiation. PMID: 16378595 Ref: Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis. PMID: 16618765 Ref: Expression of PPARdelta in multistage carcinogenesis of the colorectum: implications of malignant cancer morphology. PMID: 16969348 Ref: [The role of peroxisome proliferator-activated receptors (PPAR) in carcinogenesis]. PMID: 17076197 Ref: Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. PMID: 17148604 |
Ref: Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. PMID: 17183061 Ref: Inflammatory mediators and nuclear receptor signaling in colorectal cancer. PMID: 17374999 |
Ref: PPARdelta enhances keratinocyte proliferation in psoriasis and induces heparin-binding EGF-like growth factor. PMID: 17637826 Ref: Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. PMID: 17893232 Ref: Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARdelta/PGE2 and elevation of PGE3. PMID: 18024478 Ref: RNA interference against peroxisome proliferator-activated receptor delta gene promotes proliferation of human colorectal cancer cells. PMID: 18214615 Ref: A gut feeling of the PXR, PPAR and NF-kappaB connection. PMID: 18479261 Ref: Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease. PMID: 18616431 |
Ref: The simultaneous expression of peroxisome proliferator-activated receptor delta and cyclooxygenase-2 may enhance angiogenesis and tumor venous invasion in tissues of colorectal cancers. PMID: 18720000 Ref: Cyclooxygenase inhibitors induce colon cancer cell apoptosis Via PPARdelta --> 14-3-3epsilon pathway. PMID: 19347284 Ref: Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. PMID: 19415698 Ref: Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis. PMID: 19436036 Ref: Modulation of transcription by the peroxisome proliferator-activated receptor delta--binding RNA aptamer in colon cancer cells. PMID: 19723884 |
Ref: Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells. PMID: 19935699 Ref: [Construction of a lentiviral vector of RNA interference against PPARS gene and the establishment of colon cancer cell line KM12C with stable knockdown of PPARdelta expression]. PMID: 20481327 |
Ref: Peroxisome-proliferator-activated receptors gamma and beta/delta mediate vascular endothelial growth factor production in colorectal tumor cells. PMID: 20221637 Ref: The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients. PMID: 20824502 Ref: Functional characterization of peroxisome proliferator-activated receptor-beta/delta expression in colon cancer. PMID: 21400612 Ref: Biological function and prognostic significance of peroxisome proliferator-activated receptor delta in rectal cancer. PMID: 21531809 Ref: miR-93 suppresses proliferation and colony formation of human colon cancer stem cells. PMID: 22180714 Ref: Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). PMID: 22611424 |
Ref: The role of peroxisome proliferator-activated receptors in colorectal cancer. PMID: 23024650 Ref: beta-Catenin and peroxisome proliferator-activated receptor-delta coordinate dynamic chromatin loops for the transcription of vascular endothelial growth factor A gene in colon cancer cells. PMID: 23086933 |
Ref: Targeting peroxisome proliferator-activated receptor-beta/delta in colon cancer: how to aim? PMID: 23041232 Ref: Transcription factor AP1 binds the functional region of the promoter and regulates gene expression of human PPARdelta in LoVo cell. PMID: 23832539 Ref: Variants of the PPARD gene and their clinicopathological significance in colorectal cancer. PMID: 24391853 |
Ref: [Detection of fecal peroxisome proliferator-activated receptor delta and cyclooxygenase 2 mRNA in screening of colorectal cancer]. PMID: 24519045 Ref: Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-delta/beta overexpression. PMID: 24681603 |
Ref: 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. PMID: 25713055 |
Ref: Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-delta Pathway. PMID: 27702819 |
Ref: Metastasis regulation by PPARD expression in cancer cells. PMID: 28097239 Ref: Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer. PMID: 28128413 |
Ref: ROS release by PPARbeta/delta-null fibroblasts reduces tumor load through epithelial antioxidant response. PMID: 29367760 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 |