Primary Site >> Colorectal Cancer
Gene >> PPARA
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Ref: [Nonsteroidal anti-rheumatic drugs and colon carcinoma: COX versus PPAR]. PMID: 10234800 Ref: Impairment of peroxisomal biogenesis in human colon carcinoma. PMID: 10357777 |
Ref: PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. PMID: 10833422 Ref: Peroxisome proliferator-activated receptors in tumorigenesis: targets of tumour promotion and treatment. PMID: 10947870 Ref: Expression of peroxisome proliferator-activated receptor (PPAR)gamma in gastric cancer and inhibitory effects of PPARgamma agonists. PMID: 11044367 |
Ref: Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. PMID: 11289109 Ref: Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells. PMID: 11397807 Ref: Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. PMID: 11412039 Ref: Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. PMID: 11532858 Ref: Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells. PMID: 11713597 |
Ref: Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. PMID: 11857443 Ref: Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. PMID: 11950812 Ref: Review article: COX-2, prostanoids and colon cancer. PMID: 11966530 Ref: Expression of peroxisome proliferator-activated receptors alpha and gamma in differentiating human colon carcinoma Caco-2 cells. PMID: 12000143 Ref: Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. PMID: 12419306 Ref: Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents. PMID: 12489852 |
Ref: Activation of peroxisome proliferator-activated receptor gamma does not explain the antiproliferative activity of the nonsteroidal anti-inflammatory drug indomethacin on human colorectal cancer cells. PMID: 12606626 Ref: Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. PMID: 12622871 Ref: Polyamines as modifiers of genetic risk factors in human intestinal cancers. PMID: 12653645 Ref: The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. PMID: 12909723 Ref: Potential role for peroxisome proliferator activated receptor (PPAR) in preventing colon cancer. PMID: 12912864 Ref: The role of peroxisome proliferator-activated receptor gamma in colon cancer and inflammatory bowel disease. PMID: 12946234 Ref: Activation of PPAR gamma in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR gamma. PMID: 12949056 Ref: Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. PMID: 14506281 Ref: Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines. PMID: 14521714 Ref: Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. PMID: 14522940 Ref: [PPAR-ligands: a clinically important regulatory system with multiple options in the treatment of diabetes mellitus, inflammatory bowel disease and in the chemoprevention of colon cancer?]. PMID: 14562202 Ref: Hyperlipidic diets induce early alterations of the vitamin A signalling pathway in rat colonic mucosa. PMID: 14986719 Ref: Colonic polyps of acromegalic patients are not associated with mutations of the peroxisome proliferator activated receptor gamma gene. PMID: 15008240 |
Ref: Induction of differentiation and peroxisome proliferator-activated receptor gamma expression in colon cancer cell lines by troglitazone. PMID: 14634802 Ref: Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1). PMID: 14670614 Ref: PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells. PMID: 15177943 Ref: Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. PMID: 15182427 Ref: Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. PMID: 15535974 Ref: 3-{4-[2-[Benzoxazol-2-yl-methylamino]ethoxy]phenyl}-2-(2-[(18)F]fluoroethoxy)prop ionic acid PMID: 20641433 |
Ref: Ciglitazone induces early cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells through p65 phosphorylation. PMID: 15618021 Ref: Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice. PMID: 15710887 Ref: Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. PMID: 15764152 Ref: Selective activation of PPARgamma in breast, colon, and lung cancer cell lines. PMID: 15866424 Ref: Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. PMID: 15892897 Ref: 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal tra PMID: 16077033 Ref: Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? PMID: 16126938 |
Ref: Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. PMID: 16106401 Ref: Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. PMID: 16288226 Ref: Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms. PMID: 16303758 Ref: Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. PMID: 16343055 Ref: Isoform specific changes in PPAR alpha and beta in colon and breast cancer with differentiation. PMID: 16378595 Ref: Peroxisome proliferator-activated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in Singapore. PMID: 16513680 Ref: [Refined deletion mapping of loss of heterozygosity on 22q13 in sporadic colorectal carcinoma]. PMID: 16555160 Ref: Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice. PMID: 16606335 Ref: [The role of peroxisome proliferator-activated receptors (PPAR) in carcinogenesis]. PMID: 17076197 |
Ref: Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines. PMID: 17389773 Ref: Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner. PMID: 17390024 Ref: Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. PMID: 17442990 Ref: Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice. PMID: 17631136 Ref: Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. PMID: 17632092 Ref: Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. PMID: 17711445 Ref: Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells. PMID: 18029776 |
Ref: Influence of peroxisome proliferator-activated receptor (PPAR)gamma Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese. PMID: 17763950 Ref: Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. PMID: 18095365 Ref: PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells. PMID: 18203887 Ref: A gut feeling of the PXR, PPAR and NF-kappaB connection. PMID: 18479261 Ref: PPARgamma Inhibitors as Novel Tubulin-Targeting Agents. PMID: 18509498 Ref: Synergistic Effects of PPARgamma Ligands and Retinoids in Cancer Treatment. PMID: 18528526 Ref: Does the lipid-lowering peroxisome proliferator-activated receptors ligand bezafibrate prevent colon cancer in patients with coronary artery disease? PMID: 18565233 Ref: Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines. PMID: 18648741 Ref: PPAR alpha and PPAR delta transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. PMID: 18797151 Ref: Relationship between arachidonic acid pathway and human renal cell carcinoma. PMID: 21127751 |
Ref: Influence of tumor peroxisome proliferator-activated receptor gamma and delta expression on postoperative mortality of patients undergoing colorectal cancer surgery. PMID: 19283612 Ref: Cyclooxygenase inhibitors induce colon cancer cell apoptosis Via PPARdelta --> 14-3-3epsilon pathway. PMID: 19347284 Ref: Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. PMID: 19415698 Ref: KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. PMID: 19551868 Ref: Modulation of transcription by the peroxisome proliferator-activated receptor delta--binding RNA aptamer in colon cancer cells. PMID: 19723884 Ref: 15-lipoxygenase-1 in colorectal cancer: a review. PMID: 19752603 Ref: Decreased polyunsaturated Fatty Acid content contributes to increased survival in human colon cancer. PMID: 19841681 |
Ref: RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells. PMID: 20510503 Ref: Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. PMID: 20540935 |
Ref: Peroxisome-proliferator-activated receptors gamma and beta/delta mediate vascular endothelial growth factor production in colorectal tumor cells. PMID: 20221637 Ref: The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients. PMID: 20824502 Ref: Adiponectin supports cell survival in glucose deprivation through enhancement of autophagic response in colorectal cancer cells. PMID: 21299716 Ref: Biological function and prognostic significance of peroxisome proliferator-activated receptor delta in rectal cancer. PMID: 21531809 Ref: Simulated colon fiber metabolome regulates genes involved in cell cycle, apoptosis, and energy metabolism in human colon cancer cells. PMID: 21667160 Ref: Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. PMID: 21822537 Ref: MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells. PMID: 22036718 Ref: Cancer chemopreventive ability of conjugated linolenic acids. PMID: 22174613 |
Ref: Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARdelta in inflammation-induced colon carcinogenesis. PMID: 21940900 Ref: AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells. PMID: 22619672 Ref: The role of peroxisome proliferator-activated receptors in the esophageal, gastric, and colorectal cancer. PMID: 22991505 Ref: The role of peroxisome proliferator-activated receptors in colorectal cancer. PMID: 23024650 Ref: beta-Catenin and peroxisome proliferator-activated receptor-delta coordinate dynamic chromatin loops for the transcription of vascular endothelial growth factor A gene in colon cancer cells. PMID: 23086933 |
Ref: Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice. PMID: 23001810 Ref: Trans fatty acids affect cellular viability of human intestinal Caco-2 cells and activate peroxisome proliferator-activated receptors. PMID: 23368924 Ref: Characterization of PPAR dual ligand MCC-555 in AOM-induced colorectal tumorigenesis. PMID: 23369238 Ref: Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells. PMID: 23438367 Ref: Knockdown of PPAR delta gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model. PMID: 23593291 Ref: Analysis of key genes and pathways associated with colorectal cancer with microarray technology. PMID: 23679280 Ref: The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARgamma. PMID: 23843037 |
Ref: PPARdelta deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells. PMID: 24610641 Ref: Peroxisome proliferator-activated receptor gamma-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer. PMID: 24631504 Ref: Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-delta/beta overexpression. PMID: 24681603 Ref: Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/beta-catenin signaling while up-regulating ligand dependent transcription factor PPARgamma. PMID: 24721324 Ref: Alterations in lipid mediated signaling and Wnt/ beta -catenin signaling in DMH induced colon cancer on supplementation of fish oil. PMID: 24999478 Ref: Oxaliplatin neurotoxicity involves peroxisome alterations. PPARgamma agonism as preventive pharmacological approach. PMID: 25036594 Ref: Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARgamma/OCTN2 pathway. PMID: 25075794 |
Ref: Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer. PMID: 25379721 Ref: Voluntary exercise prevents colonic inflammation in high-fat diet-induced obese mice by up-regulating PPAR-gamma activity. PMID: 25701789 Ref: 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. PMID: 25713055 Ref: PPARdelta signaling regulates colorectal cancer. PMID: 26004416 Ref: L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-gamma Signaling Pathway. PMID: 26452216 Ref: Effect of dapagliflozin on colon cancer cell [Rapid Communication]. PMID: 26522271 Ref: Peroxisome proliferator-activated receptor-gamma is downregulated in ulcerative colitis and is involved in experimental colitis-associated neoplasia. PMID: 26622660 |
Ref: Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer. PMID: 26493186 Ref: L-carnitine ameliorates the liver inflammatory response by regulating carnitine palmitoyltransferase I-dependent PPARgamma signaling. PMID: 26647854 Ref: Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. PMID: 26731300 Ref: Clinical relevance of cyclooxygenase 2 and peroxisome proliferator-activated receptor gamma in eyelid sebaceous gland carcinoma. PMID: 26791964 Ref: Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ Mice. PMID: 26833665 Ref: Palmitoylethanolamide Exerts Antiproliferative Effect and Downregulates VEGF Signaling in Caco-2 Human Colon Carcinoma Cell Line Through a Selective PPAR-alpha-Dependent Inhibition of Akt/mTOR Pathway. PMID: 26929026 Ref: SIRT1 prevents hyperuricemia via the PGC-1alpha/PPARgamma-ABCG2 pathway. PMID: 27022940 Ref: The gastrointestinal tract - a central organ of cannabinoid signaling in health and disease. PMID: 27561826 Ref: Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-delta Pathway. PMID: 27702819 Ref: Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity. PMID: 27829137 |
Ref: HMGCS2 enhances invasion and metastasis via direct interaction with PPARalpha to activate Src signaling in colorectal cancer and oral cancer. PMID: 27816970 Ref: New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity. PMID: 28076827 Ref: A PPAR-gamma agonist protects from radiation-induced intestinal toxicity. PMID: 28344789 Ref: The genetic basis of obesity complications. PMID: 28362475 Ref: Anti-fibrogenic effect of PPAR-gamma agonists in human intestinal myofibroblasts. PMID: 28592228 Ref: Systemic analysis of different colorectal cancer cell lines and TCGA datasets identified IGF-1R/EGFR-PPAR-CASPASE axis as important indicator for radiotherapy sensitivity. PMID: 28687332 Ref: Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/beta-catenin Signaling. PMID: 28811361 |
Ref: Genistein and daidzein induce apoptosis of colon cancer cells by inhibiting the accumulation of lipid droplets. PMID: 29849534 Ref: Lyophilized acai pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells. PMID: 30194994 Ref: CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-beta-producing macrophages and T cells. PMID: 30279515 |